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• W3097675557 endingPage "108342" @default.
• W3097675557 startingPage "108342" @default.
• W3097675557 abstract "Micronuclei (MNi) are among the most widely studied biomarkers of DNA damage and chromosomal instability in humans. They originate from chromosome fragments or intact chromosomes that are not included in daughter nuclei during mitosis. The main reasons for their formation are a lack of functional centromere in the chromosome fragments or whole chromosomes or defects in one or more of the proteins of the mitotic system that, consequently, fails to segregate chromosomes properly. Assays have been developed to measure MNi in peripheral blood lymphocytes, red blood cells as well as various types of epithelial cells such as buccal, nasal, urothelial and cervical cells. Some of the assays have been further developed into micronucleus (MN) cytome assays to include additional nuclear anomalies, cell death and nuclear division biomarkers. In addition, the use of molecular probes has been adopted widely for the purpose of understanding the mechanistic origin of MNi. MN assays in humans are used for the purpose of investigating the genotoxic effects of adverse environmental, life-style and occupational factors, genetic susceptibility to DNA damage, and for determining risk of accelerated aging and diseases affected by genomic instability such as developmental defects and cancer. The emerging new knowledge showing that chromosomes trapped in MNi can undergo a high rate of fragmentation and become massively re-arranged have highlighted the possibility that MN formation is not only a biomarker of induced DNA damage but also a mechanism that drives hypermutation. Furthermore, another line of recent research showed that DNA and chromatin leaking from disrupted MNi triggers the innate immune cGAS-STING mechanism that promotes inflammation which can cause a wide-range of age-related diseases if left unresolved. For these reasons, MN assays in humans have become an increasingly important biomarker of disease initiation and progression across all life-stages." @default.
• W3097675557 created "2020-11-09" @default.
• W3097675557 creator A5007026104 @default.
• W3097675557 creator A5007283353 @default.
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• W3097675557 creator A5036709192 @default.
• W3097675557 creator A5043023935 @default.
• W3097675557 creator A5069029853 @default.
• W3097675557 date "2020-10-01" @default.
• W3097675557 modified "2023-10-17" @default.
• W3097675557 title "Micronuclei as biomarkers of DNA damage, aneuploidy, inducers of chromosomal hypermutation and as sources of pro-inflammatory DNA in humans" @default.
• W3097675557 cites W1068608310 @default.
• W3097675557 cites W1140116790 @default.
• W3097675557 cites W131898812 @default.
• W3097675557 cites W1509269909 @default.
• W3097675557 cites W1601755300 @default.
• W3097675557 cites W1604875426 @default.
• W3097675557 cites W1906506906 @default.
• W3097675557 cites W1936017830 @default.
• W3097675557 cites W1963660578 @default.
• W3097675557 cites W1965505970 @default.
• W3097675557 cites W1965724734 @default.
• W3097675557 cites W1970836866 @default.
• W3097675557 cites W1971162072 @default.
• W3097675557 cites W1973580600 @default.
• W3097675557 cites W1981847315 @default.
• W3097675557 cites W1982340345 @default.
• W3097675557 cites W1989951043 @default.
• W3097675557 cites W1990807470 @default.
• W3097675557 cites W1992795418 @default.
• W3097675557 cites W1992966555 @default.
• W3097675557 cites W1996621285 @default.
• W3097675557 cites W2018842128 @default.
• W3097675557 cites W2024264346 @default.
• W3097675557 cites W2026518249 @default.
• W3097675557 cites W2027600073 @default.
• W3097675557 cites W2030380703 @default.
• W3097675557 cites W2038275182 @default.
• W3097675557 cites W2039152070 @default.
• W3097675557 cites W2043036198 @default.
• W3097675557 cites W2050896501 @default.
• W3097675557 cites W2053521435 @default.
• W3097675557 cites W2058866238 @default.
• W3097675557 cites W2060565226 @default.
• W3097675557 cites W2061060581 @default.
• W3097675557 cites W2062896439 @default.
• W3097675557 cites W2066150390 @default.
• W3097675557 cites W2066357142 @default.
• W3097675557 cites W2068478574 @default.
• W3097675557 cites W2068552741 @default.
• W3097675557 cites W2070739953 @default.
• W3097675557 cites W2073415401 @default.
• W3097675557 cites W2077145482 @default.
• W3097675557 cites W2083797876 @default.
• W3097675557 cites W2085520064 @default.
• W3097675557 cites W2091558333 @default.
• W3097675557 cites W2093310181 @default.
• W3097675557 cites W2094161519 @default.
• W3097675557 cites W2098883242 @default.
• W3097675557 cites W2112784018 @default.
• W3097675557 cites W2112865167 @default.
• W3097675557 cites W2113812496 @default.
• W3097675557 cites W2124919647 @default.
• W3097675557 cites W2125342705 @default.
• W3097675557 cites W2125961266 @default.
• W3097675557 cites W2126673711 @default.
• W3097675557 cites W2129899300 @default.
• W3097675557 cites W2130509690 @default.
• W3097675557 cites W2131028776 @default.
• W3097675557 cites W2131308162 @default.
• W3097675557 cites W2132368565 @default.
• W3097675557 cites W2132607882 @default.
• W3097675557 cites W2139019668 @default.
• W3097675557 cites W2146513374 @default.
• W3097675557 cites W2149177144 @default.
• W3097675557 cites W2154277583 @default.
• W3097675557 cites W2155557577 @default.
• W3097675557 cites W2156944164 @default.
• W3097675557 cites W2157238336 @default.
• W3097675557 cites W2162319796 @default.
• W3097675557 cites W2162514372 @default.
• W3097675557 cites W2163234786 @default.
• W3097675557 cites W2163510568 @default.
• W3097675557 cites W2165408551 @default.
• W3097675557 cites W2169805676 @default.
• W3097675557 cites W2169984682 @default.
• W3097675557 cites W2196629030 @default.
• W3097675557 cites W2197269124 @default.
• W3097675557 cites W2232841288 @default.
• W3097675557 cites W2304220282 @default.
• W3097675557 cites W2321936919 @default.
• W3097675557 cites W2359539382 @default.
• W3097675557 cites W2398259502 @default.
• W3097675557 cites W2415610297 @default.
• W3097675557 cites W2512557209 @default.
• W3097675557 cites W2519745468 @default.
• W3097675557 cites W2559865743 @default.
• W3097675557 cites W2606476067 @default.

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