Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097689059> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W3097689059 abstract "Abstract Introduction/Objective Acute interstitial pneumonia (AIP) is a rare disease clinically characterized by rapidly progressing respiratory failure in individuals with no history of respiratory illness or other inciting factors. While most often diagnosed in middle-aged adults, it may present in any age group. Initial presentation is described as influenza- like, and respiratory failure requiring ventilatory support often progresses within weeks to months. Prognosis is poor, with an estimated mortality rate approaching 80% without treatment. Methods We present the case of a 44-year-old male nonsmoker with no significant medical history, who presented in 2018 with 1.5 months of dyspnea and headache initially diagnosed as atypical pneumonia. Chest imaging revealed bilateral opacities; however, microbial workup revealed no evidence of infectious etiology. Autoimmune serology studies were likewise unrevealing. Despite aggressive supportive and medical management, he deteriorated to respiratory failure and succumbed. Results At autopsy, the lungs were symmetrically congested and edematous (combined weight 2,340 g) but free of evident consolidation or discrete lesions. Microscopic examination revealed diffuse alveolar damage with extensive hyaline membrane formation, interstitial edema, and fibroblastic proliferation. The vasculature was severely congested, and the alveoli contained hemorrhage and scattered macrophages. No fungal or mycobacterial elements were identified by staining. Based on the histologic features and clinical context, the diagnosis of AIP was made. Conclusion AIP is a rare, aggressive, and diagnostically challenging disease that includes a broad range of both clinical and histologic differentials. Timely recognition and intervention with aggressive respiratory support and high- dose glucocorticoids are the mainstays of clinical management. The diagnostic role of histology is significant, but hinges on early clinical consideration of AIP as disease progression may later preclude the biopsy procedure. We share this case to raise awareness of this rapidly progressive and diagnostically troubling interstitial lung disease while emphasizing the importance of clinicopathologic correlation." @default.
- W3097689059 created "2020-11-09" @default.
- W3097689059 creator A5021637818 @default.
- W3097689059 creator A5038821873 @default.
- W3097689059 creator A5084668730 @default.
- W3097689059 creator A5088336251 @default.
- W3097689059 date "2020-10-01" @default.
- W3097689059 modified "2023-09-23" @default.
- W3097689059 title "A Rare Case of Acute Interstitial Pneumonia Diagnosed at Autopsy" @default.
- W3097689059 doi "https://doi.org/10.1093/ajcp/aqaa161.335" @default.
- W3097689059 hasPublicationYear "2020" @default.
- W3097689059 type Work @default.
- W3097689059 sameAs 3097689059 @default.
- W3097689059 citedByCount "0" @default.
- W3097689059 crossrefType "journal-article" @default.
- W3097689059 hasAuthorship W3097689059A5021637818 @default.
- W3097689059 hasAuthorship W3097689059A5038821873 @default.
- W3097689059 hasAuthorship W3097689059A5084668730 @default.
- W3097689059 hasAuthorship W3097689059A5088336251 @default.
- W3097689059 hasConcept C118494813 @default.
- W3097689059 hasConcept C126322002 @default.
- W3097689059 hasConcept C137627325 @default.
- W3097689059 hasConcept C142724271 @default.
- W3097689059 hasConcept C151730666 @default.
- W3097689059 hasConcept C206179267 @default.
- W3097689059 hasConcept C2776888751 @default.
- W3097689059 hasConcept C2777714996 @default.
- W3097689059 hasConcept C2777914695 @default.
- W3097689059 hasConcept C2779343474 @default.
- W3097689059 hasConcept C2779504383 @default.
- W3097689059 hasConcept C2781137159 @default.
- W3097689059 hasConcept C2909621147 @default.
- W3097689059 hasConcept C71924100 @default.
- W3097689059 hasConcept C86803240 @default.
- W3097689059 hasConcept C9418649 @default.
- W3097689059 hasConceptScore W3097689059C118494813 @default.
- W3097689059 hasConceptScore W3097689059C126322002 @default.
- W3097689059 hasConceptScore W3097689059C137627325 @default.
- W3097689059 hasConceptScore W3097689059C142724271 @default.
- W3097689059 hasConceptScore W3097689059C151730666 @default.
- W3097689059 hasConceptScore W3097689059C206179267 @default.
- W3097689059 hasConceptScore W3097689059C2776888751 @default.
- W3097689059 hasConceptScore W3097689059C2777714996 @default.
- W3097689059 hasConceptScore W3097689059C2777914695 @default.
- W3097689059 hasConceptScore W3097689059C2779343474 @default.
- W3097689059 hasConceptScore W3097689059C2779504383 @default.
- W3097689059 hasConceptScore W3097689059C2781137159 @default.
- W3097689059 hasConceptScore W3097689059C2909621147 @default.
- W3097689059 hasConceptScore W3097689059C71924100 @default.
- W3097689059 hasConceptScore W3097689059C86803240 @default.
- W3097689059 hasConceptScore W3097689059C9418649 @default.
- W3097689059 hasLocation W30976890591 @default.
- W3097689059 hasOpenAccess W3097689059 @default.
- W3097689059 hasPrimaryLocation W30976890591 @default.
- W3097689059 hasRelatedWork W14427484 @default.
- W3097689059 hasRelatedWork W15939832 @default.
- W3097689059 hasRelatedWork W19726426 @default.
- W3097689059 hasRelatedWork W19791260 @default.
- W3097689059 hasRelatedWork W1989489 @default.
- W3097689059 hasRelatedWork W2472722 @default.
- W3097689059 hasRelatedWork W3050611 @default.
- W3097689059 hasRelatedWork W3230626 @default.
- W3097689059 hasRelatedWork W4168940 @default.
- W3097689059 hasRelatedWork W5675595 @default.
- W3097689059 isParatext "false" @default.
- W3097689059 isRetracted "false" @default.
- W3097689059 magId "3097689059" @default.
- W3097689059 workType "article" @default.