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- W3097691672 abstract "Introduction: Two antifibrotic medications (pirfenidone and nintedanib) were approved for the treatment of idiopathic pulmonary fibrosis (IPF) in the US in 2014. However, few studies have examined the real-world prevalence or patient (pt) characteristics associated with use of these therapies. Objectives: To analyze real-world data to determine the prevalence and characteristics of IPF pts treated with nintedanib or pirfenidone. Methods: Adult pts with an incident IPF diagnosis (based on ICD codes) between 10/01/14 and 03/31/18 in the US-based Optum Clinformatics Data Mart database were included. The index date was the initial IPF diagnosis date. Pts with other interstitial lung disease diagnoses were excluded. Rate of antifibrotic therapy use within 12 months of index was calculated. Baseline demographics, comorbid conditions, physician specialty, and healthcare utilization were compared between pts who did and did not receive antifibrotic therapy. Results: Among 2,925 identified IPF pts, 351 (12%) received antifibrotic therapy within 12 months. These pts were younger (73.2 vs 76.4 years), more likely to be male (65.0% vs 50.2%), and had a lower Charlson Comorbidity Index score (0.70 vs 1.16) than those who did not receive antifibrotic therapy (all p Conclusions: The uptake of antifibrotic medications appears to have been slow and the majority of real-world IPF patients remain untreated with these agents, indicating that the unmet need remains high in IPF." @default.
- W3097691672 created "2020-11-09" @default.
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- W3097691672 date "2020-09-07" @default.
- W3097691672 modified "2023-09-25" @default.
- W3097691672 title "Prevalence and Characteristics of Patients Receiving Antifibrotic Therapy for Idiopathic Pulmonary Fibrosis" @default.
- W3097691672 doi "https://doi.org/10.1183/13993003.congress-2020.1851" @default.
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