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- W3097697797 abstract "Hypertrophic cardiomyopathy (HCM) is a primary disease of myocardium diagnosed by the presence of cardiac hypertrophy in the absence of increased external load or disproportionate to it. It is mainly caused by mutation in genes coding for sarcomere proteins. MYH7 and MYBPC3, encoding myosin heavy chain 7 and myosin-binding protein C3, respectively, are the two most common causes. Patients with HCM are typically asymptomatic. Often sudden cardiac death is the first manifestation of the disease. Exercise-induced dyspnea is not uncommon, but overt heart failure—that is heart failure with preserved ejection fraction (HFpEF)—is uncommon. A subset of patients with HCM develop left ventricular outflow tract obstruction, which is an important risk factor for heart failure. Palpitations are common and often due to ventricular arrhythmias. Atrial fibrillation occurs in a subset of patients and is associated with significant worsening of symptoms. Chest pain is not uncommon and often atypical without a specific pattern. Sustained and repetitive nonsustained ventricular tachycardia, presyncope, syncope, severe hypertrophy and interstitial fibrosis, and a family history of sudden cardiac death are important risk factors for sudden cardiac death in HCM. Those at a high risk for sudden cardiac death should receive an implantable defibrillator. Beta blockers are the main pharmacologic therapy for patients with symptomatic HCM. Alcohol septal ablation and surgical myectomy are very effective in reducing the outflow tract obstruction and improving survival." @default.
- W3097697797 created "2020-11-09" @default.
- W3097697797 creator A5033247045 @default.
- W3097697797 date "2020-01-01" @default.
- W3097697797 modified "2023-10-16" @default.
- W3097697797 title "Heart Failure as a Consequence of Hypertrophic Cardiomyopathy" @default.
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