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- W3097797170 endingPage "474" @default.
- W3097797170 startingPage "474" @default.
- W3097797170 abstract "Current cancer therapeutics often insufficiently eradicate malignant cells due to the surrounding dense tumor stroma. This multi-componential tissue consists of mainly cancer-associated fibroblasts, the (compact) extracellular matrix, tumor vasculature, and tumor-associated macrophages, which all exert crucial roles in maintaining a pro-tumoral niche. Their continuous complex interactions with tumor cells promote tumor progression and metastasis, emphasizing the challenges in tumor therapy development. Over the last decade, advances in oncolytic virotherapy have shown that oncolytic viruses (OVs) are a promising multi-faceted therapeutic platform for simultaneous tumor and stroma targeting. In addition to promoting tumor cell oncolysis and systemic anti-tumor immunity, accumulating data suggest that OVs can also directly target stromal components, facilitating OV replication and spread, as well as promoting anti-tumor activity. This review provides a comprehensive overview of the interactions between native and genetically modified OVs and the different targetable tumor stromal components, and outlines strategies to improve stroma targeting by OVs." @default.
- W3097797170 created "2020-11-09" @default.
- W3097797170 creator A5009929867 @default.
- W3097797170 creator A5012844257 @default.
- W3097797170 creator A5040591138 @default.
- W3097797170 creator A5061304621 @default.
- W3097797170 date "2020-11-05" @default.
- W3097797170 modified "2023-10-14" @default.
- W3097797170 title "Simultaneous Tumor and Stroma Targeting by Oncolytic Viruses" @default.
- W3097797170 cites W1507883482 @default.
- W3097797170 cites W1542691850 @default.
- W3097797170 cites W1768741830 @default.
- W3097797170 cites W1797474275 @default.
- W3097797170 cites W1878458933 @default.
- W3097797170 cites W1921973844 @default.
- W3097797170 cites W1967397723 @default.
- W3097797170 cites W1968619900 @default.
- W3097797170 cites W1969499187 @default.
- W3097797170 cites W1976906421 @default.
- W3097797170 cites W1990550137 @default.
- W3097797170 cites W1992683182 @default.
- W3097797170 cites W1996912024 @default.
- W3097797170 cites W2000114190 @default.
- W3097797170 cites W2001277825 @default.
- W3097797170 cites W2002162019 @default.
- W3097797170 cites W2003781492 @default.
- W3097797170 cites W2023818726 @default.
- W3097797170 cites W2041062187 @default.
- W3097797170 cites W2041768758 @default.
- W3097797170 cites W2054540190 @default.
- W3097797170 cites W2056854310 @default.
- W3097797170 cites W2061000461 @default.
- W3097797170 cites W2093586799 @default.
- W3097797170 cites W2094858550 @default.
- W3097797170 cites W2097849707 @default.
- W3097797170 cites W2106253728 @default.
- W3097797170 cites W2106503298 @default.
- W3097797170 cites W2122527978 @default.
- W3097797170 cites W2125733229 @default.
- W3097797170 cites W2130464657 @default.
- W3097797170 cites W2134131552 @default.
- W3097797170 cites W2140784911 @default.
- W3097797170 cites W2141674300 @default.
- W3097797170 cites W2147471000 @default.
- W3097797170 cites W2157286839 @default.
- W3097797170 cites W2157657933 @default.
- W3097797170 cites W2160834915 @default.
- W3097797170 cites W2162863440 @default.
- W3097797170 cites W2170200594 @default.
- W3097797170 cites W2178437759 @default.
- W3097797170 cites W2292016096 @default.
- W3097797170 cites W2330601596 @default.
- W3097797170 cites W2512899508 @default.
- W3097797170 cites W2560367415 @default.
- W3097797170 cites W2582686270 @default.
- W3097797170 cites W2586368282 @default.
- W3097797170 cites W2590390825 @default.
- W3097797170 cites W2624393126 @default.
- W3097797170 cites W2730739450 @default.
- W3097797170 cites W2734284893 @default.
- W3097797170 cites W2740563246 @default.
- W3097797170 cites W2741389799 @default.
- W3097797170 cites W2755866843 @default.
- W3097797170 cites W2772023181 @default.
- W3097797170 cites W2776912235 @default.
- W3097797170 cites W2784551257 @default.
- W3097797170 cites W2785291766 @default.
- W3097797170 cites W2789900268 @default.
- W3097797170 cites W2791112611 @default.
- W3097797170 cites W2796997430 @default.
- W3097797170 cites W2800862488 @default.
- W3097797170 cites W2801151079 @default.
- W3097797170 cites W2809889057 @default.
- W3097797170 cites W2886582879 @default.
- W3097797170 cites W2888932782 @default.
- W3097797170 cites W2892787129 @default.
- W3097797170 cites W2898435366 @default.
- W3097797170 cites W2901123261 @default.
- W3097797170 cites W2901515128 @default.
- W3097797170 cites W2902146996 @default.
- W3097797170 cites W2902906220 @default.
- W3097797170 cites W2905111869 @default.
- W3097797170 cites W2911130626 @default.
- W3097797170 cites W2924296925 @default.
- W3097797170 cites W2934289782 @default.
- W3097797170 cites W2939258716 @default.
- W3097797170 cites W2941200763 @default.
- W3097797170 cites W2941384888 @default.
- W3097797170 cites W2951222857 @default.
- W3097797170 cites W2958271298 @default.
- W3097797170 cites W2962961581 @default.
- W3097797170 cites W2963936065 @default.
- W3097797170 cites W2971314814 @default.
- W3097797170 cites W2979189134 @default.
- W3097797170 cites W2981868832 @default.
- W3097797170 cites W2984628891 @default.
- W3097797170 cites W2999009233 @default.
- W3097797170 cites W2999583889 @default.