Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097804998> ?p ?o ?g. }
- W3097804998 endingPage "111439" @default.
- W3097804998 startingPage "111439" @default.
- W3097804998 abstract "The mechanical interpretation of the plethora of factors that governs cellular localization of amyloid aggregates is crucial for planning novel therapeutical interventions in neurodegenerative diseases since these aggregates exert a primary role in the proteostasis machinery. The uptake of Cell Penetrating Peptides (CPPs) conjugated with different amyloid polypeptides occurs via different endocytic processes regulated by cytoskeleton organization and cell morphology. Herein, we deepened the internalization of an amyloid system in cells cultured on nanopatterned surfaces that represent a powerful tool to shape cell and regulate its contractility. We analyzed the behavior of an amyloid model system, employing NPM1264–277 sequence, covalently conjugated to Tat fragment 48–60 as CPP. To investigate its internalization mechanism, we followed the formation of aggregates on two kinds of substrates: a flat and a nanopatterned surface. Herein, investigations during time were carried out by employing both confocal and second harmonic generation (SHG) microscopies. We showed that modifications of cellular environment affect peptide localization, its cytoplasmic translocation and the size of amyloid aggregates." @default.
- W3097804998 created "2020-11-09" @default.
- W3097804998 creator A5013228560 @default.
- W3097804998 creator A5023482246 @default.
- W3097804998 creator A5040563553 @default.
- W3097804998 creator A5048971494 @default.
- W3097804998 creator A5052989053 @default.
- W3097804998 creator A5054560195 @default.
- W3097804998 creator A5067255339 @default.
- W3097804998 date "2021-01-01" @default.
- W3097804998 modified "2023-10-16" @default.
- W3097804998 title "Effects of surface nanopatterning on internalization and amyloid aggregation of the fragment 264-277 of Nucleophosmin 1" @default.
- W3097804998 cites W1501494207 @default.
- W3097804998 cites W1922136302 @default.
- W3097804998 cites W1970572567 @default.
- W3097804998 cites W1970743655 @default.
- W3097804998 cites W1978433099 @default.
- W3097804998 cites W1988613116 @default.
- W3097804998 cites W1990619098 @default.
- W3097804998 cites W1991599983 @default.
- W3097804998 cites W1993652875 @default.
- W3097804998 cites W1993748192 @default.
- W3097804998 cites W1994299717 @default.
- W3097804998 cites W2001752859 @default.
- W3097804998 cites W2015867768 @default.
- W3097804998 cites W2016468382 @default.
- W3097804998 cites W2020015356 @default.
- W3097804998 cites W2029346749 @default.
- W3097804998 cites W2030173743 @default.
- W3097804998 cites W2042198735 @default.
- W3097804998 cites W2048404157 @default.
- W3097804998 cites W2057839591 @default.
- W3097804998 cites W2069981183 @default.
- W3097804998 cites W2070976880 @default.
- W3097804998 cites W2071441527 @default.
- W3097804998 cites W2076086273 @default.
- W3097804998 cites W2077572701 @default.
- W3097804998 cites W2077589420 @default.
- W3097804998 cites W2078504128 @default.
- W3097804998 cites W2080363706 @default.
- W3097804998 cites W2081435476 @default.
- W3097804998 cites W2102497035 @default.
- W3097804998 cites W2122333073 @default.
- W3097804998 cites W2122823449 @default.
- W3097804998 cites W2141506589 @default.
- W3097804998 cites W2143248961 @default.
- W3097804998 cites W2144622010 @default.
- W3097804998 cites W2145602209 @default.
- W3097804998 cites W2153915486 @default.
- W3097804998 cites W2156280902 @default.
- W3097804998 cites W2162349490 @default.
- W3097804998 cites W2163021896 @default.
- W3097804998 cites W2163802608 @default.
- W3097804998 cites W2164725970 @default.
- W3097804998 cites W2165818390 @default.
- W3097804998 cites W2170271633 @default.
- W3097804998 cites W2290199160 @default.
- W3097804998 cites W2313725855 @default.
- W3097804998 cites W2343343962 @default.
- W3097804998 cites W2507078134 @default.
- W3097804998 cites W2545926709 @default.
- W3097804998 cites W2552680643 @default.
- W3097804998 cites W2574347556 @default.
- W3097804998 cites W2747982721 @default.
- W3097804998 cites W2751898404 @default.
- W3097804998 cites W2765939774 @default.
- W3097804998 cites W2799638002 @default.
- W3097804998 cites W2801091560 @default.
- W3097804998 cites W2804204718 @default.
- W3097804998 cites W2886718329 @default.
- W3097804998 cites W2891856485 @default.
- W3097804998 cites W2899057815 @default.
- W3097804998 cites W2901094661 @default.
- W3097804998 cites W2911125079 @default.
- W3097804998 cites W2911482468 @default.
- W3097804998 cites W2912259266 @default.
- W3097804998 cites W2933212855 @default.
- W3097804998 cites W2940371405 @default.
- W3097804998 cites W2948661366 @default.
- W3097804998 cites W3082723213 @default.
- W3097804998 doi "https://doi.org/10.1016/j.colsurfb.2020.111439" @default.
- W3097804998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33137636" @default.
- W3097804998 hasPublicationYear "2021" @default.
- W3097804998 type Work @default.
- W3097804998 sameAs 3097804998 @default.
- W3097804998 citedByCount "13" @default.
- W3097804998 countsByYear W30978049982021 @default.
- W3097804998 countsByYear W30978049982022 @default.
- W3097804998 countsByYear W30978049982023 @default.
- W3097804998 crossrefType "journal-article" @default.
- W3097804998 hasAuthorship W3097804998A5013228560 @default.
- W3097804998 hasAuthorship W3097804998A5023482246 @default.
- W3097804998 hasAuthorship W3097804998A5040563553 @default.
- W3097804998 hasAuthorship W3097804998A5048971494 @default.
- W3097804998 hasAuthorship W3097804998A5052989053 @default.
- W3097804998 hasAuthorship W3097804998A5054560195 @default.
- W3097804998 hasAuthorship W3097804998A5067255339 @default.
- W3097804998 hasConcept C12554922 @default.