Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097805846> ?p ?o ?g. }
- W3097805846 endingPage "128" @default.
- W3097805846 startingPage "114" @default.
- W3097805846 abstract "Abstract Glioma stem cells (GSC) are a subpopulation of tumor cells with special abilities to proliferate and differentiate in gliomas. They are one of the main causes of tumor recurrence, especially under hypoxic conditions. Although long noncoding RNAs (lncRNA) are known to be involved in numerous biological processes and are implied in the occurrence of certain diseases, their role in tumor development and progression remains poorly understood. Here we explored the mechanisms by which lncRNA derived from hypoxic GSCs (H-GSC) cause glioma progression. Isolation and identification of the Linc01060 gene, the exosomes containing them, and the proteins from tumor cells regulating the gene allowed for studying the effects of Linc01060 on proliferation and glycometabolism. H-GSC exerted their effects by transferring exosomes to glioma cells, resulting in a significant increase in Linc01060 levels. Mechanistically, Linc01060 directly interacted with the transcription factor myeloid zinc finger 1 (MZF1) and enhanced its stability. Linc01060 facilitated nuclear translocation of MZF1 and promoted MZF1-mediated c-Myc transcriptional activities. In addition, c-Myc enhanced the accumulation of the hypoxia-inducible factor-1 alpha (HIF1α) at the posttranscriptional level. HIF1α bound the hormone response elements of the Linc01060 promoter, upregulating the transcription of Linc01060 gene. Clinically, Linc01060 was upregulated in glioma and was significantly correlated with tumor grade and poor clinical prognosis. Overall, these data show that secretion of Linc01060-containing exosomes from H-GSCs activates prooncogenic signaling pathways in glioma cells to promote disease progression. Significance: These findings suggest that inhibition of Linc01060-containing exosomes or targeting the Linc01060/MZF1/c-Myc/HIF1α axis may be an effective therapeutic strategy in glioma." @default.
- W3097805846 created "2020-11-09" @default.
- W3097805846 creator A5003760095 @default.
- W3097805846 creator A5004498551 @default.
- W3097805846 creator A5005278461 @default.
- W3097805846 creator A5038604464 @default.
- W3097805846 creator A5042129832 @default.
- W3097805846 creator A5043244187 @default.
- W3097805846 creator A5048567430 @default.
- W3097805846 creator A5050707734 @default.
- W3097805846 creator A5053313238 @default.
- W3097805846 creator A5057675458 @default.
- W3097805846 creator A5061401851 @default.
- W3097805846 creator A5066655201 @default.
- W3097805846 date "2021-01-01" @default.
- W3097805846 modified "2023-10-11" @default.
- W3097805846 title "Hypoxic Glioma Stem Cell–Derived Exosomes Containing Linc01060 Promote Progression of Glioma by Regulating the MZF1/c-Myc/HIF1α Axis" @default.
- W3097805846 cites W1159008209 @default.
- W3097805846 cites W1601681275 @default.
- W3097805846 cites W1950118853 @default.
- W3097805846 cites W1987656195 @default.
- W3097805846 cites W1999389436 @default.
- W3097805846 cites W1999629169 @default.
- W3097805846 cites W2000614562 @default.
- W3097805846 cites W2021536610 @default.
- W3097805846 cites W2035895041 @default.
- W3097805846 cites W2048255587 @default.
- W3097805846 cites W2072506120 @default.
- W3097805846 cites W2094809025 @default.
- W3097805846 cites W2096330942 @default.
- W3097805846 cites W2097862336 @default.
- W3097805846 cites W2109429658 @default.
- W3097805846 cites W2116039248 @default.
- W3097805846 cites W2134807618 @default.
- W3097805846 cites W2147590200 @default.
- W3097805846 cites W2158325162 @default.
- W3097805846 cites W2160171104 @default.
- W3097805846 cites W2160757449 @default.
- W3097805846 cites W2162872779 @default.
- W3097805846 cites W2168414172 @default.
- W3097805846 cites W2169465106 @default.
- W3097805846 cites W2175100525 @default.
- W3097805846 cites W2245239316 @default.
- W3097805846 cites W2264671620 @default.
- W3097805846 cites W2318433546 @default.
- W3097805846 cites W2335029242 @default.
- W3097805846 cites W2339382576 @default.
- W3097805846 cites W2366536035 @default.
- W3097805846 cites W2576845640 @default.
- W3097805846 cites W2583546331 @default.
- W3097805846 cites W2610210333 @default.
- W3097805846 cites W2622355554 @default.
- W3097805846 cites W2670484694 @default.
- W3097805846 cites W2745238423 @default.
- W3097805846 cites W2753081919 @default.
- W3097805846 cites W2809283188 @default.
- W3097805846 cites W2891731843 @default.
- W3097805846 cites W2904628185 @default.
- W3097805846 cites W2904802348 @default.
- W3097805846 cites W2908798485 @default.
- W3097805846 cites W2921566266 @default.
- W3097805846 cites W2933301357 @default.
- W3097805846 cites W2943588752 @default.
- W3097805846 cites W2954167484 @default.
- W3097805846 cites W2965299749 @default.
- W3097805846 cites W2971469357 @default.
- W3097805846 cites W2971698053 @default.
- W3097805846 cites W2975237861 @default.
- W3097805846 cites W2977446819 @default.
- W3097805846 cites W2983014891 @default.
- W3097805846 cites W2998357850 @default.
- W3097805846 cites W3006404818 @default.
- W3097805846 cites W3015961195 @default.
- W3097805846 cites W3022593701 @default.
- W3097805846 cites W3035003987 @default.
- W3097805846 cites W3036976815 @default.
- W3097805846 cites W4211105004 @default.
- W3097805846 cites W630412634 @default.
- W3097805846 doi "https://doi.org/10.1158/0008-5472.can-20-2270" @default.
- W3097805846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33158815" @default.
- W3097805846 hasPublicationYear "2021" @default.
- W3097805846 type Work @default.
- W3097805846 sameAs 3097805846 @default.
- W3097805846 citedByCount "65" @default.
- W3097805846 countsByYear W30978058462021 @default.
- W3097805846 countsByYear W30978058462022 @default.
- W3097805846 countsByYear W30978058462023 @default.
- W3097805846 crossrefType "journal-article" @default.
- W3097805846 hasAuthorship W3097805846A5003760095 @default.
- W3097805846 hasAuthorship W3097805846A5004498551 @default.
- W3097805846 hasAuthorship W3097805846A5005278461 @default.
- W3097805846 hasAuthorship W3097805846A5038604464 @default.
- W3097805846 hasAuthorship W3097805846A5042129832 @default.
- W3097805846 hasAuthorship W3097805846A5043244187 @default.
- W3097805846 hasAuthorship W3097805846A5048567430 @default.
- W3097805846 hasAuthorship W3097805846A5050707734 @default.
- W3097805846 hasAuthorship W3097805846A5053313238 @default.
- W3097805846 hasAuthorship W3097805846A5057675458 @default.