FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097831415> ?p ?o ?g. }

• W3097831415 endingPage "38" @default.
• W3097831415 startingPage "36" @default.
• W3097831415 abstract "Background T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is an uncommon variant of diffuse large B cell lymphoma (DLBCL), characterized by low content of lymphoma cells in a background of extensive infiltrate of T-cells and histiocytes. Historically, THRLBCL was considered an aggressive variant of DLBCL with poorer outcomes and a 3-year OS &lt;50% (Achten et al., J Clin Oncol, 2002). To date, most series evaluating outcomes for patients (pts) with THRLBCL were published in the pre-rituximab era. Recent analysis suggested that outcomes for this disease may be better for pts treated in the rituximab era (Ollila et el., Leukemia & Lymphoma, 2009). However, data regarding treatment patterns and outcomes for pts with THRLBCL in the rituximab era is limited. We aimed to describe the clinical characteristics, prognostic factors, response to treatment, and outcome among pts diagnosed with THRLBCL at Memorial Sloan Kettering Cancer Center (MSKCC) in the rituximab era. Patients and Methods We retrospectively reviewed all cases of THRLBCL who were diagnosed in our center from January 2000 to October 2019. We collected data for demographic and clinical characteristics, pathology results, disease stage and sites of involvement, treatment regimen, and outcome. Fisher's exact test was used to assess associations between patient characteristics and treatment regimen. Fisher's exact test and Wilcoxon test were used to assess associations between categorical or continuous characteristics and response to treatment, respectively. The likelihood ratio test was used to assess significance of Cox regression univariate models. Overall survival (OS) was measured from date of diagnosis until last follow up or death. Event-free survival (EFS) was measured from end of treatment to last follow up or pathology proven relapse or disease progression. Survival curves were estimated using the Kaplan Meier method. Results A total of 100 pts were diagnosed with THRLBCL at our center during the study period. We excluded 33 pts who had missing data regarding stage, frontline treatment, or response. A total of 67 pts were included for analysis in our cohort. Median follow up duration among survivors was 3.4 years (range 0.4-10.8 years). Baseline characteristics are summarized in table 1. Forty-eight were males (72%). Median age at diagnosis was 41 years (range 19-86). Fifty-three (72%) pts were diagnosed at stage IV. Thirty-five (52%) pts had involvement of more than 1 extra-nodal site. The most common extranodal site was bone (60%). Fourteen pts had a positive bone marrow biopsy (26% of those evaluated). Univariate analysis was performed for age, gender, ethnicity, stage, extra-nodal sites, presence of B symptoms, performance status, elevated LDH, IPI score&gt;=3, and history of NLPHL. None of these factors were found significantly associated with response rate, EFS, or OS. Frontline treatment is shown in table 2 and included R-CHOP or R-CHOP based treatment in 48% (n=32), R-EPOCH in 12% (n=8), R-CHOP/R-ICE (4 cycles of R-CHOP-14 followed by 3 cycles of R-ICE, Moskowitz CH, et al. JCO 2010) in 33% (n=22) and other regimens in 7.5% (n=5). CNS prophylactic treatment was given in 19 pts. One pt had an autologous stem cell transplant and 1 pt had an allogeneic stem cell transplant as part of frontline treatment. Fifty-one (76%) pts had a complete response (CR) to frontline treatment. Among these pts, 6 relapsed. Sixteen (24%) pts had refractory disease. Among pts with relapsed or refractory disease, 18 received additional therapy. In the whole cohort, 3-year EFS was 68% and 3-year OS was 85%. In a sub-group analysis of pts who received R-CHOP/R-ICE compared to pts who were treated with R-CHOP or R-EPOCH, CR rates were 95% and 70% respectively (p=0.014). The R-CHOP/R-ICE regimen was also associated with higher 3-year EFS of 86% compared to 62% (p=0.049) and a better 3-year OS of 100% compared with 79% (p=0.016). See figures 1-2. The 2 treatment groups were not significantly different with regards to baseline characteristics. Conclusions Our study demonstrates better outcomes among pts with THRLBCL compared to available historical data from the pre-rituximab era. In addition, with the limitation of a retrospective, single-center study, our data suggests that for newly diagnosed THRLBCL, treatment with a higher intensity regimen, such as R-CHOP/R-ICE, may be associated with favorable outcome. Disclosures Batlevi: Life Sci, GLG, Juno/Celgene, Seattle Genetics, Kite: Consultancy; Janssen, Novartis, Epizyme, Xynomics, Bayer, Autolus, Roche/Genentech: Research Funding. Falchi:Roche: Research Funding; Genmab: Research Funding. Hamlin:Molecular Templates: Research Funding; Portola Pharmaceutics: Consultancy; J&J Pharmaceuticals: Research Funding; Incyte: Research Funding; Celgene: Consultancy; Juno Therapeutics: Consultancy; Karyopharm: Consultancy; Portola: Research Funding. Horwitz:Forty Seven: Consultancy, Research Funding; ADCT Therapeutics: Consultancy, Research Funding; ASTEX: Consultancy; Beigene: Consultancy; Portola: Consultancy, Research Funding; Mundipharma: Consultancy; Innate Pharma: Consultancy; Corvus: Consultancy; Trillium: Consultancy, Research Funding; Seattle Genetics: Consultancy, Research Funding; Millenium/Takeda: Consultancy, Research Funding; Verastem: Consultancy, Research Funding; GlaxoSmithKline: Consultancy; Infinity/Verastem: Research Funding; Kyowa Hakka Kirin: Consultancy, Research Funding; Aileron: Consultancy, Research Funding; Vividion Therapeutics: Consultancy; Affirmed: Consultancy; Janssen: Consultancy; Kura Oncology: Consultancy; Miragen: Consultancy; Myeloid Therapeutics: Consultancy; Celgene: Consultancy, Research Funding; C4 Therapeutics: Consultancy; Daiichi Sankyo: Research Funding. Joffe:AstraZeneca: Membership on an entity's Board of Directors or advisory committees; Epizyme: Membership on an entity's Board of Directors or advisory committees. Kumar:AbbVie: Research Funding; Astra Zeneca: Honoraria, Other: Honoraria for Advisory Board; Celgene: Honoraria, Other: Honoraria for Advisory Board; Seattle Genetics: Research Funding; Pharmacyclics: Research Funding; Celgene: Research Funding; Adaptive Biotechnologies,: Research Funding; Kite Pharmaceuticals: Honoraria, Other: Honoraria for Advisory Board. Matasar:Pharmacyclics: Honoraria, Research Funding; Immunovaccine Technologies: Honoraria, Research Funding; Janssen: Honoraria, Research Funding; IGM Biosciences: Research Funding; GlaxoSmithKline: Honoraria, Research Funding; Takeda: Consultancy, Honoraria; Daiichi Sankyo: Consultancy; Seattle Genetics: Consultancy, Honoraria, Research Funding; Rocket Medical: Consultancy, Research Funding; Teva: Consultancy; F. Hoffmann-La Roche Ltd: Consultancy, Honoraria, Research Funding; Juno Therapeutics: Consultancy; Genentech, Inc.: Consultancy, Honoraria, Research Funding; Merck: Consultancy; Bayer: Consultancy, Honoraria, Research Funding. Noy:Pharmacyclics: Research Funding; Medscape: Consultancy; NIH: Research Funding; Rafael Pharma: Research Funding; Janssen: Consultancy; Pharmacyclics: Consultancy; Morphosys: Consultancy; Targeted Oncology: Consultancy. Palomba:Genentech: Research Funding; Juno: Research Funding; Regeneron: Research Funding; Novartis: Honoraria; Merck: Honoraria; Celgene: Honoraria; Juno: Honoraria; Pharmacyclics: Honoraria. Straus:Karyopharm Therapeutics: Membership on an entity's Board of Directors or advisory committees; Targeted Oncology: Consultancy, Speakers Bureau; NY Lymphoma Rounds: Consultancy; Takeda Pharmaceuticals: Research Funding, Speakers Bureau; OncLive: Speakers Bureau; Elsevier: Membership on an entity's Board of Directors or advisory committees, Other: CME writer; ASH: Other: Conference in December 2019 on HL to other physicians during ASH; Seattle Genetics: Consultancy, Membership on an entity's Board of Directors or advisory committees; Imedex, Inc.: Speakers Bureau. Vardhana:Other: Other: SAV has received honoraria from Agios Pharmaceuticals and Rheos Pharmaceuticals, is an advisor for Immunai and has consulted for ADC Therapeutics. von Keudell:Bayer: Research Funding; Genentech: Research Funding; Pharmacyclics: Research Funding. Zelenetz:Celgene: Consultancy; Gilead: Consultancy; Genentech/Roche: Consultancy; Gilead: Research Funding; Adaptive Biotechnology: Consultancy; Sandoz: Research Funding; MorphoSys: Research Funding; Celgene: Research Funding; MEI Pharma: Research Funding; Roche: Research Funding; BeiGene: Membership on an entity's Board of Directors or advisory committees; Janssen: Consultancy; Novartis: Consultancy; Amgen: Consultancy. Moskowitz:Incyte: Research Funding; Merck: Consultancy; Seattle Genetics: Consultancy; Miragen Therapeutics: Consultancy; Imbrium Therapeutics, L.P.: Consultancy; Merck: Research Funding; Bristol-Myers Squibb: Research Funding; Seattle Genetics: Research Funding." @default.
• W3097831415 created "2020-11-09" @default.
• W3097831415 creator A5001102192 @default.
• W3097831415 creator A5001663845 @default.
• W3097831415 creator A5002969644 @default.
• W3097831415 creator A5006117950 @default.
• W3097831415 creator A5012810450 @default.
• W3097831415 creator A5013453409 @default.
• W3097831415 creator A5014543424 @default.
• W3097831415 creator A5034032647 @default.
• W3097831415 creator A5042981870 @default.
• W3097831415 creator A5045676616 @default.
• W3097831415 creator A5048118946 @default.
• W3097831415 creator A5049461398 @default.
• W3097831415 creator A5051639415 @default.
• W3097831415 creator A5052659722 @default.
• W3097831415 creator A5055986807 @default.
• W3097831415 creator A5061964017 @default.
• W3097831415 creator A5062879857 @default.
• W3097831415 creator A5069406522 @default.
• W3097831415 creator A5076564214 @default.
• W3097831415 creator A5089206024 @default.
• W3097831415 creator A5090759974 @default.
• W3097831415 creator A5091619007 @default.
• W3097831415 date "2020-11-05" @default.
• W3097831415 modified "2023-09-27" @default.
• W3097831415 title "Favorable Outcomes Among Patients with T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Treated with Higher-Intensity Therapy in the Rituximab Era" @default.
• W3097831415 doi "https://doi.org/10.1182/blood-2020-136489" @default.
• W3097831415 hasPublicationYear "2020" @default.
• W3097831415 type Work @default.
• W3097831415 sameAs 3097831415 @default.
• W3097831415 citedByCount "1" @default.
• W3097831415 countsByYear W30978314152022 @default.
• W3097831415 crossrefType "journal-article" @default.
• W3097831415 hasAuthorship W3097831415A5001102192 @default.
• W3097831415 hasAuthorship W3097831415A5001663845 @default.
• W3097831415 hasAuthorship W3097831415A5002969644 @default.
• W3097831415 hasAuthorship W3097831415A5006117950 @default.
• W3097831415 hasAuthorship W3097831415A5012810450 @default.
• W3097831415 hasAuthorship W3097831415A5013453409 @default.
• W3097831415 hasAuthorship W3097831415A5014543424 @default.
• W3097831415 hasAuthorship W3097831415A5034032647 @default.
• W3097831415 hasAuthorship W3097831415A5042981870 @default.
• W3097831415 hasAuthorship W3097831415A5045676616 @default.
• W3097831415 hasAuthorship W3097831415A5048118946 @default.
• W3097831415 hasAuthorship W3097831415A5049461398 @default.
• W3097831415 hasAuthorship W3097831415A5051639415 @default.
• W3097831415 hasAuthorship W3097831415A5052659722 @default.
• W3097831415 hasAuthorship W3097831415A5055986807 @default.
• W3097831415 hasAuthorship W3097831415A5061964017 @default.
• W3097831415 hasAuthorship W3097831415A5062879857 @default.
• W3097831415 hasAuthorship W3097831415A5069406522 @default.
• W3097831415 hasAuthorship W3097831415A5076564214 @default.
• W3097831415 hasAuthorship W3097831415A5089206024 @default.
• W3097831415 hasAuthorship W3097831415A5090759974 @default.
• W3097831415 hasAuthorship W3097831415A5091619007 @default.
• W3097831415 hasBestOaLocation W30978314151 @default.
• W3097831415 hasConcept C126322002 @default.
• W3097831415 hasConcept C143998085 @default.
• W3097831415 hasConcept C203014093 @default.
• W3097831415 hasConcept C2778559949 @default.
• W3097831415 hasConcept C2779338263 @default.
• W3097831415 hasConcept C2780653079 @default.
• W3097831415 hasConcept C43100952 @default.
• W3097831415 hasConcept C71924100 @default.
• W3097831415 hasConceptScore W3097831415C126322002 @default.
• W3097831415 hasConceptScore W3097831415C143998085 @default.
• W3097831415 hasConceptScore W3097831415C203014093 @default.
• W3097831415 hasConceptScore W3097831415C2778559949 @default.
• W3097831415 hasConceptScore W3097831415C2779338263 @default.
• W3097831415 hasConceptScore W3097831415C2780653079 @default.
• W3097831415 hasConceptScore W3097831415C43100952 @default.
• W3097831415 hasConceptScore W3097831415C71924100 @default.
• W3097831415 hasIssue "Supplement 1" @default.
• W3097831415 hasLocation W30978314151 @default.
• W3097831415 hasOpenAccess W3097831415 @default.
• W3097831415 hasPrimaryLocation W30978314151 @default.
• W3097831415 hasRelatedWork W1969362652 @default.
• W3097831415 hasRelatedWork W1996279342 @default.
• W3097831415 hasRelatedWork W2125885683 @default.
• W3097831415 hasRelatedWork W2272592620 @default.
• W3097831415 hasRelatedWork W2390430401 @default.
• W3097831415 hasRelatedWork W2577135688 @default.
• W3097831415 hasRelatedWork W2915014687 @default.
• W3097831415 hasRelatedWork W2993375378 @default.
• W3097831415 hasRelatedWork W3049596273 @default.
• W3097831415 hasRelatedWork W79716904 @default.
• W3097831415 hasVolume "136" @default.
• W3097831415 isParatext "false" @default.
• W3097831415 isRetracted "false" @default.
• W3097831415 magId "3097831415" @default.
• W3097831415 workType "article" @default.