Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097858714> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3097858714 endingPage "85" @default.
- W3097858714 startingPage "78" @default.
- W3097858714 abstract "The aim of the study was to investigate antithrombogenic properties of compound RU-1144 with previously identified pronounced antiplatelet and antioxidant activities. The thrombosis induced by Ferric chloride (FeCl 3 ) was carried out in rats’ carotid artery, in comparison with the known antiaggregant drugs - acetylsalicylic acid (ASA) and clopidogrel, as well as with the antioxidant preparation - ethylmethylhydroxypyridine succinate (EMHPS). Materials and methods. The antithrombotic activity of compound RU-1144 was studied on the model of the rats with carotid artery thrombosis, induced by the application of 50% ferric chloride (FeCl 3 ), and the Global Thrombosis Test model (the Görög Thrombosis Test ). The evaluation of this type of activity was carried out by prolonging the time of a blood clot formation. The studies of the compound RU-1144 effect on the bleeding time parameter were performed in mice. Acetylsalicylic acid, clopidogrel and EMHPS were used as reference drugs. Results. The antithrombotic effect of the RU-1144 substance revealed in the model of arterial thrombosis induced by the application of ferric chloride (FeCl 3 ), exceeded that of both acetylsalicylic acid and clopidogrel by 3.5 times and that of EMHPS by 2.9 times. In the model of the in vitro Global Thrombosis Test (the Görög Thrombosis Test ), compound RU-1144 reduced the thrombogenic potential of the blood equally with acetylsalicylic acid and clopidogrel. The assessment of “the bleeding time”, caused by the RU-1144 substance, showed that the prolongation of bleeding was twice as less pronounced than that caused by ASA and clopidogrel. Conclusion. The performed studies demonstrated a pronounced antithrombotic activity of compound RU-1144, which exceeded that of acetylsalicylic acid, clopidogrel and EMHPS, while the ability to prolong the bleeding time was reliably lower than that of reference drugs. Abbreviations: EMHPS-ethylmethylhydroxypyridine succinate; ASA - acetylsalicylic acid." @default.
- W3097858714 created "2020-11-09" @default.
- W3097858714 creator A5026787498 @default.
- W3097858714 creator A5058913524 @default.
- W3097858714 creator A5067834747 @default.
- W3097858714 creator A5083499825 @default.
- W3097858714 creator A5088374716 @default.
- W3097858714 date "2020-10-14" @default.
- W3097858714 modified "2023-10-17" @default.
- W3097858714 title "ANTITROMBOTIC ACTIVITY OF A NEW BENZIMIDAZOLE DERIVATIVE WITH A SPATIALLY DIFFICULT PHENOLIC SUBSTITUTE IN ITS STRUCTURE" @default.
- W3097858714 cites W1484090672 @default.
- W3097858714 cites W1798774271 @default.
- W3097858714 cites W1979848351 @default.
- W3097858714 cites W1983937216 @default.
- W3097858714 cites W2000312990 @default.
- W3097858714 cites W2031039946 @default.
- W3097858714 cites W2056413600 @default.
- W3097858714 cites W2076003026 @default.
- W3097858714 cites W2086727094 @default.
- W3097858714 cites W2121377495 @default.
- W3097858714 cites W2146972322 @default.
- W3097858714 cites W2313122277 @default.
- W3097858714 cites W2414290644 @default.
- W3097858714 cites W2416321912 @default.
- W3097858714 cites W2470721915 @default.
- W3097858714 cites W2580792129 @default.
- W3097858714 cites W2785490330 @default.
- W3097858714 cites W2789242740 @default.
- W3097858714 cites W2921538250 @default.
- W3097858714 cites W2979468997 @default.
- W3097858714 cites W3007986137 @default.
- W3097858714 cites W4249493255 @default.
- W3097858714 doi "https://doi.org/10.19163/2307-9266-2020-8-2-78-85" @default.
- W3097858714 hasPublicationYear "2020" @default.
- W3097858714 type Work @default.
- W3097858714 sameAs 3097858714 @default.
- W3097858714 citedByCount "0" @default.
- W3097858714 crossrefType "journal-article" @default.
- W3097858714 hasAuthorship W3097858714A5026787498 @default.
- W3097858714 hasAuthorship W3097858714A5058913524 @default.
- W3097858714 hasAuthorship W3097858714A5067834747 @default.
- W3097858714 hasAuthorship W3097858714A5083499825 @default.
- W3097858714 hasAuthorship W3097858714A5088374716 @default.
- W3097858714 hasBestOaLocation W30978587141 @default.
- W3097858714 hasConcept C126322002 @default.
- W3097858714 hasConcept C141071460 @default.
- W3097858714 hasConcept C178790620 @default.
- W3097858714 hasConcept C185592680 @default.
- W3097858714 hasConcept C2777015399 @default.
- W3097858714 hasConcept C2777628954 @default.
- W3097858714 hasConcept C2777849778 @default.
- W3097858714 hasConcept C2778695967 @default.
- W3097858714 hasConcept C2779216453 @default.
- W3097858714 hasConcept C2780534640 @default.
- W3097858714 hasConcept C2780868729 @default.
- W3097858714 hasConcept C2993802102 @default.
- W3097858714 hasConcept C71924100 @default.
- W3097858714 hasConcept C89560881 @default.
- W3097858714 hasConcept C98274493 @default.
- W3097858714 hasConceptScore W3097858714C126322002 @default.
- W3097858714 hasConceptScore W3097858714C141071460 @default.
- W3097858714 hasConceptScore W3097858714C178790620 @default.
- W3097858714 hasConceptScore W3097858714C185592680 @default.
- W3097858714 hasConceptScore W3097858714C2777015399 @default.
- W3097858714 hasConceptScore W3097858714C2777628954 @default.
- W3097858714 hasConceptScore W3097858714C2777849778 @default.
- W3097858714 hasConceptScore W3097858714C2778695967 @default.
- W3097858714 hasConceptScore W3097858714C2779216453 @default.
- W3097858714 hasConceptScore W3097858714C2780534640 @default.
- W3097858714 hasConceptScore W3097858714C2780868729 @default.
- W3097858714 hasConceptScore W3097858714C2993802102 @default.
- W3097858714 hasConceptScore W3097858714C71924100 @default.
- W3097858714 hasConceptScore W3097858714C89560881 @default.
- W3097858714 hasConceptScore W3097858714C98274493 @default.
- W3097858714 hasIssue "2" @default.
- W3097858714 hasLocation W30978587141 @default.
- W3097858714 hasOpenAccess W3097858714 @default.
- W3097858714 hasPrimaryLocation W30978587141 @default.
- W3097858714 hasRelatedWork W2003528772 @default.
- W3097858714 hasRelatedWork W2003593234 @default.
- W3097858714 hasRelatedWork W2046145445 @default.
- W3097858714 hasRelatedWork W2135090615 @default.
- W3097858714 hasRelatedWork W2274031374 @default.
- W3097858714 hasRelatedWork W2327836063 @default.
- W3097858714 hasRelatedWork W2462760285 @default.
- W3097858714 hasRelatedWork W2472469044 @default.
- W3097858714 hasRelatedWork W2588554524 @default.
- W3097858714 hasRelatedWork W3097858714 @default.
- W3097858714 hasVolume "8" @default.
- W3097858714 isParatext "false" @default.
- W3097858714 isRetracted "false" @default.
- W3097858714 magId "3097858714" @default.
- W3097858714 workType "article" @default.