FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097890147> ?p ?o ?g. }

• W3097890147 endingPage "8154" @default.
• W3097890147 startingPage "8154" @default.
• W3097890147 abstract "In cognitively normal patients, mild hyperglycemia selectively decreases 18F-Fluorodeoxyglucose (FDG) uptake in the posterior brain, reproducing Alzheimer disease pattern, hampering the diagnostic accuracy of this widely used tool. This phenomenon might involve either a heterogeneous response of glucose metabolism or a different sensitivity to hyperglycemia-related redox stress. Indeed, previous studies reported a close link between FDG uptake and activation of a specific pentose phosphate pathway (PPP), triggered by hexose-6P-dehydrogenase (H6PD) and contributing to fuel NADPH-dependent antioxidant responses in the endoplasmic reticulum (ER). To clarify this issue, dynamic positron emission tomography was performed in 40 BALB/c mice four weeks after administration of saline (n = 17) or 150 mg/kg streptozotocin (n = 23, STZ). Imaging data were compared with biochemical and histological indexes of glucose metabolism and redox balance. Cortical FDG uptake was homogeneous in controls, while it was selectively decreased in the posterior brain of STZ mice. This difference was independent of the activity of enzymes regulating glycolysis and cytosolic PPP, while it was paralleled by a decreased H6PD catalytic function and enhanced indexes of oxidative damage. Thus, the relative decrease in FDG uptake of the posterior brain reflects a lower activation of ER-PPP in response to hyperglycemia-related redox stress in these areas." @default.
• W3097890147 created "2020-11-09" @default.
• W3097890147 creator A5003405783 @default.
• W3097890147 creator A5004158910 @default.
• W3097890147 creator A5010133857 @default.
• W3097890147 creator A5015367159 @default.
• W3097890147 creator A5015665108 @default.
• W3097890147 creator A5021902525 @default.
• W3097890147 creator A5024225840 @default.
• W3097890147 creator A5038942338 @default.
• W3097890147 creator A5044245930 @default.
• W3097890147 creator A5054695842 @default.
• W3097890147 creator A5057867351 @default.
• W3097890147 creator A5069546253 @default.
• W3097890147 creator A5072151058 @default.
• W3097890147 creator A5073238891 @default.
• W3097890147 creator A5084333635 @default.
• W3097890147 creator A5088779262 @default.
• W3097890147 date "2020-10-31" @default.
• W3097890147 modified "2023-10-18" @default.
• W3097890147 title "18F-Fluorodeoxyglucose Positron Emission Tomography Tracks the Heterogeneous Brain Susceptibility to the Hyperglycemia-Related Redox Stress" @default.
• W3097890147 cites W1559143190 @default.
• W3097890147 cites W1570800131 @default.
• W3097890147 cites W1931527273 @default.
• W3097890147 cites W1997753893 @default.
• W3097890147 cites W2007856779 @default.
• W3097890147 cites W2008642071 @default.
• W3097890147 cites W2010113318 @default.
• W3097890147 cites W2019227795 @default.
• W3097890147 cites W2048893204 @default.
• W3097890147 cites W2078694299 @default.
• W3097890147 cites W2083990676 @default.
• W3097890147 cites W2085208129 @default.
• W3097890147 cites W2095309401 @default.
• W3097890147 cites W2125782175 @default.
• W3097890147 cites W2148457609 @default.
• W3097890147 cites W2148703287 @default.
• W3097890147 cites W2345131055 @default.
• W3097890147 cites W2414250773 @default.
• W3097890147 cites W2535022185 @default.
• W3097890147 cites W2595124237 @default.
• W3097890147 cites W2792724494 @default.
• W3097890147 cites W2808631295 @default.
• W3097890147 cites W2837519800 @default.
• W3097890147 cites W2889117681 @default.
• W3097890147 cites W2896559737 @default.
• W3097890147 cites W2907693884 @default.
• W3097890147 cites W2908610540 @default.
• W3097890147 cites W2908803724 @default.
• W3097890147 cites W2914653869 @default.
• W3097890147 cites W2915570295 @default.
• W3097890147 cites W2938163330 @default.
• W3097890147 cites W2951138022 @default.
• W3097890147 cites W2985115016 @default.
• W3097890147 cites W3004632449 @default.
• W3097890147 cites W3016594415 @default.
• W3097890147 cites W3032976905 @default.
• W3097890147 cites W3038043602 @default.
• W3097890147 cites W3042205076 @default.
• W3097890147 doi "https://doi.org/10.3390/ijms21218154" @default.
• W3097890147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7672601" @default.
• W3097890147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33142766" @default.
• W3097890147 hasPublicationYear "2020" @default.
• W3097890147 type Work @default.
• W3097890147 sameAs 3097890147 @default.
• W3097890147 citedByCount "5" @default.
• W3097890147 countsByYear W30978901472021 @default.
• W3097890147 countsByYear W30978901472022 @default.
• W3097890147 countsByYear W30978901472023 @default.
• W3097890147 crossrefType "journal-article" @default.
• W3097890147 hasAuthorship W3097890147A5003405783 @default.
• W3097890147 hasAuthorship W3097890147A5004158910 @default.
• W3097890147 hasAuthorship W3097890147A5010133857 @default.
• W3097890147 hasAuthorship W3097890147A5015367159 @default.
• W3097890147 hasAuthorship W3097890147A5015665108 @default.
• W3097890147 hasAuthorship W3097890147A5021902525 @default.
• W3097890147 hasAuthorship W3097890147A5024225840 @default.
• W3097890147 hasAuthorship W3097890147A5038942338 @default.
• W3097890147 hasAuthorship W3097890147A5044245930 @default.
• W3097890147 hasAuthorship W3097890147A5054695842 @default.
• W3097890147 hasAuthorship W3097890147A5057867351 @default.
• W3097890147 hasAuthorship W3097890147A5069546253 @default.
• W3097890147 hasAuthorship W3097890147A5072151058 @default.
• W3097890147 hasAuthorship W3097890147A5073238891 @default.
• W3097890147 hasAuthorship W3097890147A5084333635 @default.
• W3097890147 hasAuthorship W3097890147A5088779262 @default.
• W3097890147 hasBestOaLocation W30978901471 @default.
• W3097890147 hasConcept C126322002 @default.
• W3097890147 hasConcept C134018914 @default.
• W3097890147 hasConcept C17093226 @default.
• W3097890147 hasConcept C178790620 @default.
• W3097890147 hasConcept C185592680 @default.
• W3097890147 hasConcept C20251656 @default.
• W3097890147 hasConcept C2775842073 @default.
• W3097890147 hasConcept C2776151105 @default.
• W3097890147 hasConcept C2777866211 @default.
• W3097890147 hasConcept C2779306644 @default.
• W3097890147 hasConcept C2989005 @default.

• next