Matches in SemOpenAlex for { <https://semopenalex.org/work/W3097908917> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W3097908917 endingPage "3237" @default.
- W3097908917 startingPage "3237" @default.
- W3097908917 abstract "As an antivirus drug, remdesivir is currently in clinical studies for the treatment of COVID-19 Remdesivir is a prodrug originally developed by Gilead for the treatment of Ebola The prodrug nucleotide (ProTide) technology is a prodrug-designing strategy developed by McGuigan and co-workers, in which a phosphoramidate side-chain is covalently attached to the hydroxy group of a drug molecule in order to enhance the cell permeability and metabolic activation efficiency This approach has proved to be very successful in the identification of nucleoside analogues with antiviral or antitumor activities It is also adapted in the application of non-nucleoside agents, such as neurodegeneration therapeutics, further demonstrating its usefulness in drug discovery The chirality of the pentavalent phosphorous plays a significant role in the bioactivity of a ProTide molecule Therefore, the efficient synthesis of such chemical scaffold in a highly enantioselective manner is very desirable and has intrigued great interests from both academia and pharmaceutical industry In this review, based on the reactions employing optically pure P(V) precursors or P-racemic P(V) precursors, the recent advances on the stereoselective assembly of ProTide compounds are summarized Various innovative strategies, including (dynamic) kinetic resolutions, were implemented to construct the vital P-stereogenic center with high regio- and stereo-selectivity It is notable that several methods could be performed at kilogram scale, which are highlighted to showcase their practical values in the process chemistry The asymmetric synthesis of enantiopure phosphoramidate precursors is illustrated in detail which will be informative for future drug development Moreover, the clinical performance of some investigational ProTide drugs is also briefly discussed © 2020 Chinese Chemical Society & SIOC, CAS" @default.
- W3097908917 created "2020-11-09" @default.
- W3097908917 creator A5016112062 @default.
- W3097908917 creator A5023095366 @default.
- W3097908917 creator A5038524965 @default.
- W3097908917 date "2020-01-01" @default.
- W3097908917 modified "2023-10-12" @default.
- W3097908917 title "Asymmetric Synthesis of Prodrug Nucleotides (ProTides): Construction of the P-Stereogenic Centers" @default.
- W3097908917 doi "https://doi.org/10.6023/cjoc202005030" @default.
- W3097908917 hasPublicationYear "2020" @default.
- W3097908917 type Work @default.
- W3097908917 sameAs 3097908917 @default.
- W3097908917 citedByCount "1" @default.
- W3097908917 countsByYear W30979089172021 @default.
- W3097908917 crossrefType "journal-article" @default.
- W3097908917 hasAuthorship W3097908917A5016112062 @default.
- W3097908917 hasAuthorship W3097908917A5023095366 @default.
- W3097908917 hasAuthorship W3097908917A5038524965 @default.
- W3097908917 hasBestOaLocation W30979089171 @default.
- W3097908917 hasConcept C104317684 @default.
- W3097908917 hasConcept C108215921 @default.
- W3097908917 hasConcept C134195300 @default.
- W3097908917 hasConcept C146686406 @default.
- W3097908917 hasConcept C161790260 @default.
- W3097908917 hasConcept C185592680 @default.
- W3097908917 hasConcept C512185932 @default.
- W3097908917 hasConcept C55493867 @default.
- W3097908917 hasConcept C71240020 @default.
- W3097908917 hasConceptScore W3097908917C104317684 @default.
- W3097908917 hasConceptScore W3097908917C108215921 @default.
- W3097908917 hasConceptScore W3097908917C134195300 @default.
- W3097908917 hasConceptScore W3097908917C146686406 @default.
- W3097908917 hasConceptScore W3097908917C161790260 @default.
- W3097908917 hasConceptScore W3097908917C185592680 @default.
- W3097908917 hasConceptScore W3097908917C512185932 @default.
- W3097908917 hasConceptScore W3097908917C55493867 @default.
- W3097908917 hasConceptScore W3097908917C71240020 @default.
- W3097908917 hasIssue "10" @default.
- W3097908917 hasLocation W30979089171 @default.
- W3097908917 hasOpenAccess W3097908917 @default.
- W3097908917 hasPrimaryLocation W30979089171 @default.
- W3097908917 hasRelatedWork W1986870464 @default.
- W3097908917 hasRelatedWork W2020973033 @default.
- W3097908917 hasRelatedWork W2034154804 @default.
- W3097908917 hasRelatedWork W2048555752 @default.
- W3097908917 hasRelatedWork W2050715599 @default.
- W3097908917 hasRelatedWork W2076165096 @default.
- W3097908917 hasRelatedWork W2078384490 @default.
- W3097908917 hasRelatedWork W2766919814 @default.
- W3097908917 hasRelatedWork W4226505362 @default.
- W3097908917 hasRelatedWork W4283578315 @default.
- W3097908917 hasVolume "40" @default.
- W3097908917 isParatext "false" @default.
- W3097908917 isRetracted "false" @default.
- W3097908917 magId "3097908917" @default.
- W3097908917 workType "article" @default.