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- W3098044034 endingPage "1085" @default.
- W3098044034 startingPage "1085" @default.
- W3098044034 abstract "The blood–brain barrier (BBB) is formed by brain microvascular endothelial cells that are sealed by tight junctions, making it a significant obstacle for most brain therapeutics. The poor BBB penetration of newly developed therapeutics has therefore played a major role in limiting their clinical success. A particularly challenging therapeutic target is glioma, which is the most frequently occurring malignant brain tumor. Thus, to enhance therapeutic uptake in tumors, researchers have been developing strategies to modulate BBB permeability. However, most conventional BBB opening strategies are difficult to apply in the clinical setting due to their broad, non-specific modulation of the BBB, which can result in damage to normal brain tissue. In this review, we have summarized strategies that could potentially be used to selectively and efficiently modulate the tumor BBB for more effective glioma treatment." @default.
- W3098044034 created "2020-11-23" @default.
- W3098044034 creator A5025343176 @default.
- W3098044034 creator A5064490529 @default.
- W3098044034 date "2020-11-12" @default.
- W3098044034 modified "2023-10-16" @default.
- W3098044034 title "Blood–Brain Barrier Modulation to Improve Glioma Drug Delivery" @default.
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