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• W3098049011 endingPage "12452" @default.
• W3098049011 startingPage "12436" @default.
• W3098049011 abstract "Abstract SARS-CoV-2 is a betacoronavirus with a linear single-stranded, positive-sense RNA genome, whose outbreak caused the ongoing COVID-19 pandemic. The ability of coronaviruses to rapidly evolve, adapt, and cross species barriers makes the development of effective and durable therapeutic strategies a challenging and urgent need. As for other RNA viruses, genomic RNA structures are expected to play crucial roles in several steps of the coronavirus replication cycle. Despite this, only a handful of functionally-conserved coronavirus structural RNA elements have been identified to date. Here, we performed RNA structure probing to obtain single-base resolution secondary structure maps of the full SARS-CoV-2 coronavirus genome both in vitro and in living infected cells. Probing data recapitulate the previously described coronavirus RNA elements (5′ UTR and s2m), and reveal new structures. Of these, ∼10.2% show significant covariation among SARS-CoV-2 and other coronaviruses, hinting at their functionally-conserved role. Secondary structure-restrained 3D modeling of these segments further allowed for the identification of putative druggable pockets. In addition, we identify a set of single-stranded segments in vivo, showing high sequence conservation, suitable for the development of antisense oligonucleotide therapeutics. Collectively, our work lays the foundation for the development of innovative RNA-targeted therapeutic strategies to fight SARS-related infections." @default.
• W3098049011 created "2020-11-23" @default.
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• W3098049011 date "2020-11-10" @default.
• W3098049011 modified "2023-10-15" @default.
• W3098049011 title "Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements" @default.
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• W3098049011 doi "https://doi.org/10.1093/nar/gkaa1053" @default.
• W3098049011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7736786" @default.
• W3098049011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33166999" @default.
• W3098049011 hasPublicationYear "2020" @default.
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