Matches in SemOpenAlex for { <https://semopenalex.org/work/W3098113669> ?p ?o ?g. }
- W3098113669 endingPage "8610" @default.
- W3098113669 startingPage "8603" @default.
- W3098113669 abstract "Abnormal scarring is a consequence of dysregulation in the wound healing process, with limited options for effective and noninvasive therapies. Given the ability of spherical nucleic acids (SNAs) to penetrate skin and regulate gene expression within, we investigated whether gold-core SNAs (AuSNAs) and liposome-core SNAs (LSNAs) bearing antisense oligonucleotides targeting transforming growth factor beta 1 (TGF-β1) can function as a topical therapy for scarring. Importantly, both SNA constructs appreciably downregulated TGF-β1 protein expression in primary hypertrophic and keloid scar fibroblasts in vitro. In vivo, topically applied AuSNAs and LSNAs downregulated TGF-β1 protein expression levels and improved scar histology as determined by the scar elevation index. These data underscore the potential of SNAs as a localized, self-manageable treatment for skin-related diseases and disorders that are driven by increased gene expression." @default.
- W3098113669 created "2020-11-23" @default.
- W3098113669 creator A5000364005 @default.
- W3098113669 creator A5004659058 @default.
- W3098113669 creator A5015105392 @default.
- W3098113669 creator A5020095047 @default.
- W3098113669 creator A5042546105 @default.
- W3098113669 creator A5044348796 @default.
- W3098113669 creator A5045266839 @default.
- W3098113669 creator A5051030386 @default.
- W3098113669 creator A5052493382 @default.
- W3098113669 creator A5055829204 @default.
- W3098113669 creator A5064164594 @default.
- W3098113669 creator A5070133920 @default.
- W3098113669 creator A5081096027 @default.
- W3098113669 date "2020-11-13" @default.
- W3098113669 modified "2023-10-13" @default.
- W3098113669 title "Attenuation of Abnormal Scarring Using Spherical Nucleic Acids Targeting Transforming Growth Factor Beta 1" @default.
- W3098113669 cites W1600110256 @default.
- W3098113669 cites W1850254945 @default.
- W3098113669 cites W1972917598 @default.
- W3098113669 cites W1974185118 @default.
- W3098113669 cites W1977569722 @default.
- W3098113669 cites W1994357966 @default.
- W3098113669 cites W2004755607 @default.
- W3098113669 cites W2006533920 @default.
- W3098113669 cites W2009993736 @default.
- W3098113669 cites W2016118449 @default.
- W3098113669 cites W2016747388 @default.
- W3098113669 cites W2023455126 @default.
- W3098113669 cites W2024244702 @default.
- W3098113669 cites W2031663540 @default.
- W3098113669 cites W2039614535 @default.
- W3098113669 cites W2046890061 @default.
- W3098113669 cites W2049095447 @default.
- W3098113669 cites W2049628338 @default.
- W3098113669 cites W2052566608 @default.
- W3098113669 cites W2055011359 @default.
- W3098113669 cites W2056610107 @default.
- W3098113669 cites W2061251554 @default.
- W3098113669 cites W2070192533 @default.
- W3098113669 cites W2072164275 @default.
- W3098113669 cites W2073658360 @default.
- W3098113669 cites W2085960705 @default.
- W3098113669 cites W2097103399 @default.
- W3098113669 cites W2118789657 @default.
- W3098113669 cites W2121322725 @default.
- W3098113669 cites W2122808924 @default.
- W3098113669 cites W2123550509 @default.
- W3098113669 cites W2161423477 @default.
- W3098113669 cites W2170695692 @default.
- W3098113669 cites W2237130707 @default.
- W3098113669 cites W2328640092 @default.
- W3098113669 cites W2563355458 @default.
- W3098113669 cites W2607508625 @default.
- W3098113669 cites W2613508549 @default.
- W3098113669 cites W2767530270 @default.
- W3098113669 cites W2798218560 @default.
- W3098113669 cites W2802243500 @default.
- W3098113669 cites W2942651424 @default.
- W3098113669 cites W3025786519 @default.
- W3098113669 cites W4231922148 @default.
- W3098113669 cites W4236675031 @default.
- W3098113669 cites W4237229340 @default.
- W3098113669 cites W4362217323 @default.
- W3098113669 cites W80282612 @default.
- W3098113669 doi "https://doi.org/10.1021/acsabm.0c00990" @default.
- W3098113669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7946158" @default.
- W3098113669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33709070" @default.
- W3098113669 hasPublicationYear "2020" @default.
- W3098113669 type Work @default.
- W3098113669 sameAs 3098113669 @default.
- W3098113669 citedByCount "4" @default.
- W3098113669 countsByYear W30981136692021 @default.
- W3098113669 countsByYear W30981136692022 @default.
- W3098113669 crossrefType "journal-article" @default.
- W3098113669 hasAuthorship W3098113669A5000364005 @default.
- W3098113669 hasAuthorship W3098113669A5004659058 @default.
- W3098113669 hasAuthorship W3098113669A5015105392 @default.
- W3098113669 hasAuthorship W3098113669A5020095047 @default.
- W3098113669 hasAuthorship W3098113669A5042546105 @default.
- W3098113669 hasAuthorship W3098113669A5044348796 @default.
- W3098113669 hasAuthorship W3098113669A5045266839 @default.
- W3098113669 hasAuthorship W3098113669A5051030386 @default.
- W3098113669 hasAuthorship W3098113669A5052493382 @default.
- W3098113669 hasAuthorship W3098113669A5055829204 @default.
- W3098113669 hasAuthorship W3098113669A5064164594 @default.
- W3098113669 hasAuthorship W3098113669A5070133920 @default.
- W3098113669 hasAuthorship W3098113669A5081096027 @default.
- W3098113669 hasBestOaLocation W30981136692 @default.
- W3098113669 hasConcept C104317684 @default.
- W3098113669 hasConcept C111599444 @default.
- W3098113669 hasConcept C118131993 @default.
- W3098113669 hasConcept C129312508 @default.
- W3098113669 hasConcept C142724271 @default.
- W3098113669 hasConcept C150194340 @default.
- W3098113669 hasConcept C150903083 @default.
- W3098113669 hasConcept C207001950 @default.