Matches in SemOpenAlex for { <https://semopenalex.org/work/W3098266295> ?p ?o ?g. }
- W3098266295 abstract "Abstract Breast cancer (BC) is one of the most common causes of cancer in the world and the second leading cause of cancer deaths among women. Mortality is associated mainly with the development of metastases. Identification of the mechanisms involved in metastasis formation is, therefore, a major public health issue. Among the proposed risk factors, chemical environment and pollution are increasingly suggested to have an effect on the signaling pathways involved in metastatic tumor cells emergence and progression. The purpose of this article is to summarize current knowledge about the role of environmental chemicals in breast cancer progression, metastasis formation and resistance to chemotherapy. Through a scoping review, we highlight the effects of a wide variety of environmental toxicants, including persistent organic pollutants and endocrine disruptors, on invasion mechanisms and metastatic processes in BC. We identified the epithelial-to-mesenchymal transition and cancer-stemness (the stem cell-like phenotype in tumors), two mechanisms suspected of playing key roles in the development of metastases and linked to chemoresistance, as potential targets of contaminants. We discuss then the recently described pro-migratory and pro-invasive Ah receptor signaling pathway and conclude that his role in BC progression is still controversial. In conclusion, although several pertinent pathways for the effects of xenobiotics have been identified, the mechanisms of actions for multiple other molecules remain to be established. The integral role of xenobiotics in the exposome in BC needs to be further explored through additional relevant epidemiological studies that can be extended to molecular mechanisms." @default.
- W3098266295 created "2020-11-23" @default.
- W3098266295 creator A5006306925 @default.
- W3098266295 creator A5023863154 @default.
- W3098266295 creator A5056436797 @default.
- W3098266295 creator A5058260355 @default.
- W3098266295 creator A5073561748 @default.
- W3098266295 creator A5081135844 @default.
- W3098266295 date "2020-11-17" @default.
- W3098266295 modified "2023-10-17" @default.
- W3098266295 title "Environmental chemicals, breast cancer progression and drug resistance" @default.
- W3098266295 cites W1567050923 @default.
- W3098266295 cites W1573746641 @default.
- W3098266295 cites W1685917468 @default.
- W3098266295 cites W1718522256 @default.
- W3098266295 cites W1955644177 @default.
- W3098266295 cites W1966230547 @default.
- W3098266295 cites W1967368426 @default.
- W3098266295 cites W1976121644 @default.
- W3098266295 cites W1978192120 @default.
- W3098266295 cites W1979292119 @default.
- W3098266295 cites W1980162425 @default.
- W3098266295 cites W1982714712 @default.
- W3098266295 cites W1984678083 @default.
- W3098266295 cites W1985508272 @default.
- W3098266295 cites W1986969470 @default.
- W3098266295 cites W1993245715 @default.
- W3098266295 cites W1993889000 @default.
- W3098266295 cites W1995077721 @default.
- W3098266295 cites W1995899860 @default.
- W3098266295 cites W1996193517 @default.
- W3098266295 cites W1998110092 @default.
- W3098266295 cites W1998142996 @default.
- W3098266295 cites W1999251458 @default.
- W3098266295 cites W2000021455 @default.
- W3098266295 cites W2002010599 @default.
- W3098266295 cites W2002013266 @default.
- W3098266295 cites W2003503254 @default.
- W3098266295 cites W2003798516 @default.
- W3098266295 cites W2004419844 @default.
- W3098266295 cites W2004854210 @default.
- W3098266295 cites W2007091438 @default.
- W3098266295 cites W2007225446 @default.
- W3098266295 cites W2007897263 @default.
- W3098266295 cites W2010603591 @default.
- W3098266295 cites W2011674713 @default.
- W3098266295 cites W2019519475 @default.
- W3098266295 cites W2019651377 @default.
- W3098266295 cites W2020574893 @default.
- W3098266295 cites W2022024600 @default.
- W3098266295 cites W2023149623 @default.
- W3098266295 cites W2028593825 @default.
- W3098266295 cites W2031096462 @default.
- W3098266295 cites W2036149098 @default.
- W3098266295 cites W2036792438 @default.
- W3098266295 cites W2039877846 @default.
- W3098266295 cites W2039880020 @default.
- W3098266295 cites W2047874826 @default.
- W3098266295 cites W2049795516 @default.
- W3098266295 cites W2050837172 @default.
- W3098266295 cites W2051729077 @default.
- W3098266295 cites W2051785676 @default.
- W3098266295 cites W2052931153 @default.
- W3098266295 cites W2054178406 @default.
- W3098266295 cites W2055468037 @default.
- W3098266295 cites W2055642522 @default.
- W3098266295 cites W2055727607 @default.
- W3098266295 cites W2056548559 @default.
- W3098266295 cites W2058494666 @default.
- W3098266295 cites W2061221413 @default.
- W3098266295 cites W2062509860 @default.
- W3098266295 cites W2067509142 @default.
- W3098266295 cites W2072222745 @default.
- W3098266295 cites W2072666254 @default.
- W3098266295 cites W2072832440 @default.
- W3098266295 cites W2073681480 @default.
- W3098266295 cites W2074420260 @default.
- W3098266295 cites W2076204015 @default.
- W3098266295 cites W2076927594 @default.
- W3098266295 cites W2077957963 @default.
- W3098266295 cites W2078204613 @default.
- W3098266295 cites W2080232352 @default.
- W3098266295 cites W2081454519 @default.
- W3098266295 cites W2086596704 @default.
- W3098266295 cites W2091726431 @default.
- W3098266295 cites W2097193479 @default.
- W3098266295 cites W2097893055 @default.
- W3098266295 cites W2097989455 @default.
- W3098266295 cites W2098423712 @default.
- W3098266295 cites W2103409364 @default.
- W3098266295 cites W2104497443 @default.
- W3098266295 cites W2106162177 @default.
- W3098266295 cites W2108360007 @default.
- W3098266295 cites W2109162829 @default.
- W3098266295 cites W2119835079 @default.
- W3098266295 cites W2120364751 @default.
- W3098266295 cites W2122468835 @default.
- W3098266295 cites W2127239893 @default.
- W3098266295 cites W2131487381 @default.
- W3098266295 cites W2133776611 @default.