Matches in SemOpenAlex for { <https://semopenalex.org/work/W3098528237> ?p ?o ?g. }
- W3098528237 endingPage "4434" @default.
- W3098528237 startingPage "4420" @default.
- W3098528237 abstract "Gemcitabine has been a commonly used therapeutic agent for treatment of pancreatic cancer. In the clinic, a growing resistance to gemcitabine has been observed in patients with pancreatic cancer, and investigation of the underlying mechanism of gemcitabine resistance is urgently required. The microRNA (miRNA)-producing enzyme, Dicer, is crucial for the maturation of miRNAs, and is involved in clinical aggressiveness, poor prognosis, and survival outcomes in various cancers, however, the role of Dicer in acquired gemcitabine resistance of pancreatic cancer is still not clear. Here, we found that Dicer expression was significantly increased in gemcitabine-resistant PANC-1 (PANC-1/GEM) cells compared with parental PANC-1 cells and observed a high level of Dicer correlated with increased risk of pancreatic cancer. Suppression of Dicer obviously decreased gemcitabine resistance in PANC-1/GEM cells; consistently, overexpression of Dicer in PANC-1 cells increased gemcitabine resistance. Moreover, we identified that transcriptional factor Sp1 targeted the promoter region of Dicer and found ERK/Sp1 signaling regulated Dicer expression in PANC-1/GEM cells, as well as positively correlated with pancreatic cancer progression and suggest that targeting the ERK/Sp1/Dicer pathway has potential therapeutic value for pancreatic cancer with acquired resistance to gemcitabine." @default.
- W3098528237 created "2020-11-23" @default.
- W3098528237 creator A5021624628 @default.
- W3098528237 creator A5035097562 @default.
- W3098528237 creator A5038678963 @default.
- W3098528237 creator A5045347568 @default.
- W3098528237 creator A5046487166 @default.
- W3098528237 creator A5054499877 @default.
- W3098528237 creator A5065608915 @default.
- W3098528237 creator A5068278994 @default.
- W3098528237 creator A5088240595 @default.
- W3098528237 date "2020-11-13" @default.
- W3098528237 modified "2023-10-17" @default.
- W3098528237 title "ERK‐mediated transcriptional activation of <i>Dicer</i> is involved in gemcitabine resistance of pancreatic cancer" @default.
- W3098528237 cites W1496395664 @default.
- W3098528237 cites W1548282121 @default.
- W3098528237 cites W1551666838 @default.
- W3098528237 cites W1976797572 @default.
- W3098528237 cites W1983722200 @default.
- W3098528237 cites W1985960583 @default.
- W3098528237 cites W1989056960 @default.
- W3098528237 cites W2005866954 @default.
- W3098528237 cites W2009363310 @default.
- W3098528237 cites W2013242321 @default.
- W3098528237 cites W2013859796 @default.
- W3098528237 cites W2014769235 @default.
- W3098528237 cites W2015009944 @default.
- W3098528237 cites W2019805139 @default.
- W3098528237 cites W2035470707 @default.
- W3098528237 cites W2036788851 @default.
- W3098528237 cites W2042968293 @default.
- W3098528237 cites W2044303305 @default.
- W3098528237 cites W2047256111 @default.
- W3098528237 cites W2049088975 @default.
- W3098528237 cites W2051143932 @default.
- W3098528237 cites W2054493435 @default.
- W3098528237 cites W2056028275 @default.
- W3098528237 cites W2056213387 @default.
- W3098528237 cites W2058326304 @default.
- W3098528237 cites W2061587220 @default.
- W3098528237 cites W2067755792 @default.
- W3098528237 cites W2072049513 @default.
- W3098528237 cites W2077330022 @default.
- W3098528237 cites W2086578788 @default.
- W3098528237 cites W2099241751 @default.
- W3098528237 cites W2103946207 @default.
- W3098528237 cites W2105108260 @default.
- W3098528237 cites W2129197203 @default.
- W3098528237 cites W2142043048 @default.
- W3098528237 cites W2144712720 @default.
- W3098528237 cites W2151625863 @default.
- W3098528237 cites W2164134009 @default.
- W3098528237 cites W2165948908 @default.
- W3098528237 cites W2201118654 @default.
- W3098528237 cites W2328205009 @default.
- W3098528237 cites W2415018300 @default.
- W3098528237 cites W2579147068 @default.
- W3098528237 cites W2610920336 @default.
- W3098528237 cites W2725356970 @default.
- W3098528237 cites W2736410015 @default.
- W3098528237 cites W2774974877 @default.
- W3098528237 cites W2776366613 @default.
- W3098528237 cites W2806285085 @default.
- W3098528237 cites W3217677266 @default.
- W3098528237 cites W4244578979 @default.
- W3098528237 doi "https://doi.org/10.1002/jcp.30159" @default.
- W3098528237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33184874" @default.
- W3098528237 hasPublicationYear "2020" @default.
- W3098528237 type Work @default.
- W3098528237 sameAs 3098528237 @default.
- W3098528237 citedByCount "11" @default.
- W3098528237 countsByYear W30985282372021 @default.
- W3098528237 countsByYear W30985282372022 @default.
- W3098528237 countsByYear W30985282372023 @default.
- W3098528237 crossrefType "journal-article" @default.
- W3098528237 hasAuthorship W3098528237A5021624628 @default.
- W3098528237 hasAuthorship W3098528237A5035097562 @default.
- W3098528237 hasAuthorship W3098528237A5038678963 @default.
- W3098528237 hasAuthorship W3098528237A5045347568 @default.
- W3098528237 hasAuthorship W3098528237A5046487166 @default.
- W3098528237 hasAuthorship W3098528237A5054499877 @default.
- W3098528237 hasAuthorship W3098528237A5065608915 @default.
- W3098528237 hasAuthorship W3098528237A5068278994 @default.
- W3098528237 hasAuthorship W3098528237A5088240595 @default.
- W3098528237 hasConcept C104317684 @default.
- W3098528237 hasConcept C121608353 @default.
- W3098528237 hasConcept C126322002 @default.
- W3098528237 hasConcept C145059251 @default.
- W3098528237 hasConcept C22615655 @default.
- W3098528237 hasConcept C2779867133 @default.
- W3098528237 hasConcept C2780210213 @default.
- W3098528237 hasConcept C2780258809 @default.
- W3098528237 hasConcept C502942594 @default.
- W3098528237 hasConcept C54009773 @default.
- W3098528237 hasConcept C54355233 @default.
- W3098528237 hasConcept C57074206 @default.
- W3098528237 hasConcept C62478195 @default.
- W3098528237 hasConcept C71924100 @default.