Matches in SemOpenAlex for { <https://semopenalex.org/work/W3098605778> ?p ?o ?g. }
- W3098605778 startingPage "685099" @default.
- W3098605778 abstract "Abstract Serotonin regulates developmental and experience-dependent neuroplasticity in limbic-prefrontal systems engaged in emotional reactivity and regulation. Tryptophan hydroxylase 2 (TPH2) regulates central serotonergic biosynthesis rates and transgenic animal models suggest that TPH2-associated changes in serotonergic signaling mediate the impact of early life stress (ELS) shaping a phenotype characterized by anxious avoidance. The present study employed an imaging genomics approach that capitalized on individual differences in a TPH2 polymorphism (703G/T; rs4570625) to determine whether differences in serotonergic signaling modulate the effects of ELS on brain structure and function and punishment sensitivity in humans (n = 252). Higher ELS exposure was associated with increased gray matter volumes in a circuitry spanning thalamic-limbic-prefrontal regions and decreased intrinsic communication in limbic-prefrontal circuits selectively in TT carriers. On the phenotype level, the genotype moderated the association between higher ELS exposure and higher punishment sensitivity. In TT carriers, the association between higher ELS exposure and punishment sensitivity was critically mediated by increased thalamic-limbic-prefrontal volumes. The present findings suggest that ELS shapes the neural organization of the thalamic-limbic-prefrontal circuits in interaction with individual variations in TPH2 to promote a phenotype characterized by facilitated threat avoidance, thus promoting early adaptation to an adverse environment." @default.
- W3098605778 created "2020-11-23" @default.
- W3098605778 creator A5007408091 @default.
- W3098605778 creator A5009879798 @default.
- W3098605778 creator A5012156936 @default.
- W3098605778 creator A5022713595 @default.
- W3098605778 creator A5027835607 @default.
- W3098605778 creator A5031293241 @default.
- W3098605778 creator A5044053690 @default.
- W3098605778 creator A5044395226 @default.
- W3098605778 creator A5046992579 @default.
- W3098605778 creator A5053370052 @default.
- W3098605778 creator A5066710210 @default.
- W3098605778 creator A5068078572 @default.
- W3098605778 creator A5077760321 @default.
- W3098605778 creator A5078936001 @default.
- W3098605778 creator A5091509770 @default.
- W3098605778 date "2019-06-27" @default.
- W3098605778 modified "2023-09-23" @default.
- W3098605778 title "Gene - Environment Interaction: A TPH2 polymorphism and early life stress shape brain architecture and anxious avoidant behavior" @default.
- W3098605778 cites W1168447193 @default.
- W3098605778 cites W1519591349 @default.
- W3098605778 cites W1717791288 @default.
- W3098605778 cites W1919558196 @default.
- W3098605778 cites W1921511099 @default.
- W3098605778 cites W1964006502 @default.
- W3098605778 cites W1972646149 @default.
- W3098605778 cites W1976114760 @default.
- W3098605778 cites W1980430635 @default.
- W3098605778 cites W1982547105 @default.
- W3098605778 cites W1987375729 @default.
- W3098605778 cites W1987493933 @default.
- W3098605778 cites W1988059569 @default.
- W3098605778 cites W1992474739 @default.
- W3098605778 cites W1993159686 @default.
- W3098605778 cites W1994950269 @default.
- W3098605778 cites W1995031937 @default.
- W3098605778 cites W1996299251 @default.
- W3098605778 cites W1997421960 @default.
- W3098605778 cites W1998578646 @default.
- W3098605778 cites W1998973288 @default.
- W3098605778 cites W2005238835 @default.
- W3098605778 cites W2008083196 @default.
- W3098605778 cites W2014711343 @default.
- W3098605778 cites W2019742184 @default.
- W3098605778 cites W2020866758 @default.
- W3098605778 cites W2025909281 @default.
- W3098605778 cites W2033849577 @default.
- W3098605778 cites W2035884658 @default.
- W3098605778 cites W2038702827 @default.
- W3098605778 cites W2043590800 @default.
- W3098605778 cites W2054571943 @default.
- W3098605778 cites W2058046532 @default.
- W3098605778 cites W2062405004 @default.
- W3098605778 cites W2064372566 @default.
- W3098605778 cites W2065514195 @default.
- W3098605778 cites W2069683199 @default.
- W3098605778 cites W2070615835 @default.
- W3098605778 cites W2071559186 @default.
- W3098605778 cites W2076201141 @default.
- W3098605778 cites W2078738825 @default.
- W3098605778 cites W2079348783 @default.
- W3098605778 cites W2080496806 @default.
- W3098605778 cites W2080574727 @default.
- W3098605778 cites W2091523264 @default.
- W3098605778 cites W2092446347 @default.
- W3098605778 cites W2095651162 @default.
- W3098605778 cites W2099384073 @default.
- W3098605778 cites W2100158580 @default.
- W3098605778 cites W2111862001 @default.
- W3098605778 cites W2114123537 @default.
- W3098605778 cites W2118136004 @default.
- W3098605778 cites W2123001443 @default.
- W3098605778 cites W2125029186 @default.
- W3098605778 cites W2126693856 @default.
- W3098605778 cites W2127436676 @default.
- W3098605778 cites W2127438603 @default.
- W3098605778 cites W2132175842 @default.
- W3098605778 cites W2142560086 @default.
- W3098605778 cites W2147591377 @default.
- W3098605778 cites W2151027504 @default.
- W3098605778 cites W2155298532 @default.
- W3098605778 cites W2156265515 @default.
- W3098605778 cites W2157217869 @default.
- W3098605778 cites W2160253364 @default.
- W3098605778 cites W2162176738 @default.
- W3098605778 cites W2165478810 @default.
- W3098605778 cites W2168444083 @default.
- W3098605778 cites W2208939678 @default.
- W3098605778 cites W2216711948 @default.
- W3098605778 cites W2252439817 @default.
- W3098605778 cites W2290190425 @default.
- W3098605778 cites W2299336385 @default.
- W3098605778 cites W2317663870 @default.
- W3098605778 cites W2414922822 @default.
- W3098605778 cites W2437949077 @default.
- W3098605778 cites W2522772114 @default.
- W3098605778 cites W2551165271 @default.
- W3098605778 cites W2589232582 @default.