Matches in SemOpenAlex for { <https://semopenalex.org/work/W3098608045> ?p ?o ?g. }
- W3098608045 endingPage "36" @default.
- W3098608045 startingPage "23" @default.
- W3098608045 abstract "Techniques for clinical genetic testing in dementia disorders have advanced rapidly but remain to be more widely implemented in practice. A positive genetic test offers a precise molecular diagnosis, can help members of an affected family to determine personal risk, provides a basis for reproductive choices and can offer options for clinical trials. The likelihood of identifying a specific genetic cause of dementia depends on the clinical condition, the age at onset and family history. Attempts to match phenotypes to single genes are mostly inadvisable owing to clinical overlap between the dementias, genetic heterogeneity, pleiotropy and concurrent mutations. Currently, the appropriate genetic test in most cases of dementia is a next-generation sequencing gene panel, though some conditions necessitate specific types of test such as repeat expansion testing. Whole-exome and whole-genome sequencing are becoming financially feasible but raise or exacerbate complex issues such as variants of uncertain significance, secondary findings and the potential for re-analysis in light of new information. However, the capacity for data analysis and counselling is already restricting the provision of genetic testing. Patients and their relatives need to be given reliable information to enable them to make informed choices about tests, treatments and data sharing; the ability of patients with dementia to make decisions must be considered when providing this information. In this Review, the authors discuss how technological advances are enabling clinical genetic testing for various dementia disorders. Additionally, they consider which types of test are appropriate for which patients and address the ethical issues that can be raised by genetic testing in these disorders." @default.
- W3098608045 created "2020-11-23" @default.
- W3098608045 creator A5018836358 @default.
- W3098608045 creator A5020582481 @default.
- W3098608045 creator A5041885603 @default.
- W3098608045 creator A5045615014 @default.
- W3098608045 creator A5065370594 @default.
- W3098608045 creator A5082436384 @default.
- W3098608045 creator A5083470216 @default.
- W3098608045 creator A5085975040 @default.
- W3098608045 creator A5086893120 @default.
- W3098608045 date "2020-11-09" @default.
- W3098608045 modified "2023-10-16" @default.
- W3098608045 title "Genetic testing in dementia — utility and clinical strategies" @default.
- W3098608045 cites W1260792146 @default.
- W3098608045 cites W1484496882 @default.
- W3098608045 cites W1511517753 @default.
- W3098608045 cites W1529591158 @default.
- W3098608045 cites W1552917344 @default.
- W3098608045 cites W1570680710 @default.
- W3098608045 cites W1578815908 @default.
- W3098608045 cites W1808711893 @default.
- W3098608045 cites W1888689427 @default.
- W3098608045 cites W1965252410 @default.
- W3098608045 cites W1969271586 @default.
- W3098608045 cites W1977370966 @default.
- W3098608045 cites W1982974205 @default.
- W3098608045 cites W1986339708 @default.
- W3098608045 cites W1996240521 @default.
- W3098608045 cites W2003117699 @default.
- W3098608045 cites W2005731595 @default.
- W3098608045 cites W2006769360 @default.
- W3098608045 cites W2007370270 @default.
- W3098608045 cites W2009284112 @default.
- W3098608045 cites W2009783224 @default.
- W3098608045 cites W2017079501 @default.
- W3098608045 cites W2018584963 @default.
- W3098608045 cites W2021123830 @default.
- W3098608045 cites W2022714591 @default.
- W3098608045 cites W2034319596 @default.
- W3098608045 cites W2039135161 @default.
- W3098608045 cites W2039263342 @default.
- W3098608045 cites W2042376210 @default.
- W3098608045 cites W2043498599 @default.
- W3098608045 cites W2046590674 @default.
- W3098608045 cites W2051978340 @default.
- W3098608045 cites W2059772902 @default.
- W3098608045 cites W2072698534 @default.
- W3098608045 cites W2073704038 @default.
- W3098608045 cites W2076046933 @default.
- W3098608045 cites W2076434774 @default.
- W3098608045 cites W2077113245 @default.
- W3098608045 cites W2078512370 @default.
- W3098608045 cites W2079253178 @default.
- W3098608045 cites W2082429191 @default.
- W3098608045 cites W2082825869 @default.
- W3098608045 cites W2084197946 @default.
- W3098608045 cites W2086892854 @default.
- W3098608045 cites W2088645009 @default.
- W3098608045 cites W2095798723 @default.
- W3098608045 cites W2097433680 @default.
- W3098608045 cites W2098546816 @default.
- W3098608045 cites W2098752510 @default.
- W3098608045 cites W2106786486 @default.
- W3098608045 cites W2110174245 @default.
- W3098608045 cites W2114999674 @default.
- W3098608045 cites W2115779804 @default.
- W3098608045 cites W2119818111 @default.
- W3098608045 cites W2120786099 @default.
- W3098608045 cites W2121642311 @default.
- W3098608045 cites W2121729186 @default.
- W3098608045 cites W2124490243 @default.
- W3098608045 cites W2127237723 @default.
- W3098608045 cites W2129250133 @default.
- W3098608045 cites W2129497119 @default.
- W3098608045 cites W2132680751 @default.
- W3098608045 cites W2134310798 @default.
- W3098608045 cites W2134318672 @default.
- W3098608045 cites W2138956466 @default.
- W3098608045 cites W2139238476 @default.
- W3098608045 cites W2141455952 @default.
- W3098608045 cites W2144021643 @default.
- W3098608045 cites W2145210308 @default.
- W3098608045 cites W2147718170 @default.
- W3098608045 cites W2151406645 @default.
- W3098608045 cites W2152119060 @default.
- W3098608045 cites W2152745352 @default.
- W3098608045 cites W2153168932 @default.
- W3098608045 cites W2154675985 @default.
- W3098608045 cites W2154945114 @default.
- W3098608045 cites W2159280728 @default.
- W3098608045 cites W2192508127 @default.
- W3098608045 cites W2193207784 @default.
- W3098608045 cites W2252255302 @default.
- W3098608045 cites W2256016639 @default.
- W3098608045 cites W2267433380 @default.
- W3098608045 cites W2270303516 @default.
- W3098608045 cites W2306696647 @default.