FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3098615857> ?p ?o ?g. }

• W3098615857 abstract "Abstract Glioblastoma multiforme (GBM) is the most common malignant brain cancer that invades normal brain tissue and impedes surgical eradication, resulting in early local recurrence and high mortality. In addition, most therapeutic agents lack permeability across the blood brain barrier (BBB), further reducing the efficacy of chemotherapy. Thus, effective treatment against GBM requires tumor specific targets and efficient intracranial drug delivery. With the most recent advances in immunotherapy, genetically engineered T cells with chimeric antigen receptors (CARs) are becoming a promising approach for treating cancer. By transducing T lymphocytes with CAR constructs containing a tumor-associated antigen (TAA) recognition domain linked to the constant regions of a signaling T cell receptor, CAR T cells may recognize a predefined TAA with high specificity in a non-MHC restricted manner, and is independent of antigen processing. Active T cells can travel across the BBB, providing additional advantage for drug delivery and tumor targeting. Here we review the CAR design and technical innovations, the major targets that are in pre-clinical and clinical development with a focus on GBM, and multiple strategies developed to improve CAR T cell efficacy." @default.
• W3098615857 created "2020-11-23" @default.
• W3098615857 creator A5016594547 @default.
• W3098615857 creator A5048925301 @default.
• W3098615857 creator A5074158848 @default.
• W3098615857 creator A5080946473 @default.
• W3098615857 creator A5090868034 @default.
• W3098615857 date "2020-11-11" @default.
• W3098615857 modified "2023-10-13" @default.
• W3098615857 title "Chimeric antigen receptor T-cell therapy in glioblastoma: charging the T cells to fight" @default.
• W3098615857 cites W1828443506 @default.
• W3098615857 cites W1858612658 @default.
• W3098615857 cites W1956825767 @default.
• W3098615857 cites W1973317990 @default.
• W3098615857 cites W1985579610 @default.
• W3098615857 cites W1987633400 @default.
• W3098615857 cites W1987790028 @default.
• W3098615857 cites W1989860131 @default.
• W3098615857 cites W2003624697 @default.
• W3098615857 cites W2009914447 @default.
• W3098615857 cites W2016523043 @default.
• W3098615857 cites W2025183726 @default.
• W3098615857 cites W2027863358 @default.
• W3098615857 cites W2033677608 @default.
• W3098615857 cites W2038702089 @default.
• W3098615857 cites W2042258261 @default.
• W3098615857 cites W2044402738 @default.
• W3098615857 cites W2047205338 @default.
• W3098615857 cites W2051947815 @default.
• W3098615857 cites W2052279202 @default.
• W3098615857 cites W2068512864 @default.
• W3098615857 cites W2087055812 @default.
• W3098615857 cites W2094945699 @default.
• W3098615857 cites W2105400883 @default.
• W3098615857 cites W2110641339 @default.
• W3098615857 cites W2111034570 @default.
• W3098615857 cites W2114147900 @default.
• W3098615857 cites W2114601875 @default.
• W3098615857 cites W2124446900 @default.
• W3098615857 cites W2148523692 @default.
• W3098615857 cites W2149992805 @default.
• W3098615857 cites W2150291313 @default.
• W3098615857 cites W2151246207 @default.
• W3098615857 cites W2154115071 @default.
• W3098615857 cites W2155584393 @default.
• W3098615857 cites W2159222883 @default.
• W3098615857 cites W2168369189 @default.
• W3098615857 cites W2169579205 @default.
• W3098615857 cites W2256857837 @default.
• W3098615857 cites W2258336271 @default.
• W3098615857 cites W2285621780 @default.
• W3098615857 cites W2318486612 @default.
• W3098615857 cites W2319926262 @default.
• W3098615857 cites W2335365056 @default.
• W3098615857 cites W2396185671 @default.
• W3098615857 cites W2481298264 @default.
• W3098615857 cites W2526887159 @default.
• W3098615857 cites W2530531760 @default.
• W3098615857 cites W2547869005 @default.
• W3098615857 cites W2548694234 @default.
• W3098615857 cites W2553096714 @default.
• W3098615857 cites W2558333564 @default.
• W3098615857 cites W2560189464 @default.
• W3098615857 cites W2563647161 @default.
• W3098615857 cites W2566018578 @default.
• W3098615857 cites W2567424265 @default.
• W3098615857 cites W2605626471 @default.
• W3098615857 cites W2606325744 @default.
• W3098615857 cites W2609343346 @default.
• W3098615857 cites W2612833955 @default.
• W3098615857 cites W2617490000 @default.
• W3098615857 cites W2621082482 @default.
• W3098615857 cites W2626092744 @default.
• W3098615857 cites W2685700956 @default.
• W3098615857 cites W2738678436 @default.
• W3098615857 cites W2742534733 @default.
• W3098615857 cites W2747383311 @default.
• W3098615857 cites W2755677601 @default.
• W3098615857 cites W2764040657 @default.
• W3098615857 cites W2783304290 @default.
• W3098615857 cites W2788755715 @default.
• W3098615857 cites W2790863559 @default.
• W3098615857 cites W2791451678 @default.
• W3098615857 cites W2792588868 @default.
• W3098615857 cites W2803040262 @default.
• W3098615857 cites W2808090012 @default.
• W3098615857 cites W2810896552 @default.
• W3098615857 cites W2890522709 @default.
• W3098615857 cites W2897977935 @default.
• W3098615857 cites W2901098499 @default.
• W3098615857 cites W2906344733 @default.
• W3098615857 cites W2910164268 @default.
• W3098615857 cites W2911752971 @default.
• W3098615857 cites W2921120275 @default.
• W3098615857 cites W2922661875 @default.
• W3098615857 cites W2965262659 @default.
• W3098615857 cites W2990797394 @default.
• W3098615857 cites W2996644149 @default.
• W3098615857 cites W3004461655 @default.
• W3098615857 cites W3004836354 @default.

• next