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- W309864567 abstract "SummaryCytomegalovirus infections occur in the majority of all populations examined and once acquired remain in a latent state throughout the lifespan of the individual infected. Immunosuppressed individuals, particularly transplant recipients have increased severity of primary infections due to this agent and not infrequently reactivate the latent infection. Disseminated infections occur with resultant mortality in patients with underlying diseases, especially bone marrow transplant recipients. Retinitis due to CMV has been reported in over 30 patients and occurs in immunosuppressed patients. Fourteen cases of retinitis were seen at one institution and seven were treated with systemically administered adenine arabinoside. A dosage of 20 mg/kg was associated with improvement in retinitis and a decrease in quantitative shedding of CMV in the urine. Improvement was observed in several cases following lowering of immunosuppression without antiviral therapy. Significant side effects, mainly hematologic and gastrointestinal were observed at the dosages required. Certain patients with progressive retinitis due to CMV may respond to therapy with adenine arabinoside, but require frequent monitoring for side effects before and after such treatments." @default.
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- W309864567 date "1981-01-01" @default.
- W309864567 modified "2023-09-25" @default.
- W309864567 title "Infections With Cytomegalovirus in Adults and the Natural History and Treatment of Cytomegalovirus Retinitis" @default.
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- W309864567 doi "https://doi.org/10.1007/978-3-642-80499-1_80" @default.
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