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- W3098659610 abstract "Abstract Over the last 50 years, there has been a steady decline in fertility rates in humans, which has occurred in parallel with an increasing incidence of obesity and metabolic disorders. The potential impact of these disorders and plausible mechanisms by which they negatively influence male reproduction are only partly understood and published data are often controversial. Obesity is one of the most important health challenges worldwide and is becoming more prevalent in children and adolescents. Obesity, the metabolic syndrome and related co-morbidities can lead to impaired male reproductive function, including adverse effects on spermatogenesis and steroidogenesis as illustrated by reduced sperm number and quality, decreased testosterone levels and elevated inflammatory markers. The incidence of diabetes mellitus type I is also dramatically increasing and may negatively impact spermatogenesis and testicular function, resulting in decreased serum testosterone and epididymal weight. In this review, we summarize and discuss the effects of metabolic diseases that typically develop during childhood and adolescence on later reproductive function and fertility. While impact on reproductive health is likely observed in both sexes, we have chosen to focus on the male in the current review. Specifically, we illustrate adverse effects of obesity, type 1 diabetes, the metabolic syndrome and insulin resistance on sperm function and testosterone metabolism. Identification of pathophysiological mechanisms during childhood may open up new avenues for early prevention and treatment resulting in better reproductive outcomes and improved fertility rates during adulthood." @default.
- W3098659610 created "2020-11-23" @default.
- W3098659610 creator A5046023727 @default.
- W3098659610 creator A5054296137 @default.
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- W3098659610 creator A5079178357 @default.
- W3098659610 date "2020-11-13" @default.
- W3098659610 modified "2023-10-17" @default.
- W3098659610 title "Adverse effects of metabolic disorders in childhood on adult reproductive function and fertility in the male" @default.
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- W3098659610 doi "https://doi.org/10.1515/jpem-2020-0276" @default.
- W3098659610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33185575" @default.
- W3098659610 hasPublicationYear "2020" @default.
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