Matches in SemOpenAlex for { <https://semopenalex.org/work/W3098678168> ?p ?o ?g. }
- W3098678168 abstract "Abstract Histone-modifying systems play fundamental roles in gene regulation and the development of multicellular organisms. Histone modifications that are enriched at gene regulatory elements have been heavily studied, but the function of modifications that are found more broadly throughout the genome remains poorly understood. This is exemplified by histone H2A mono-ubiquitylation (H2AK119ub1) which is enriched at Polycomb-repressed gene promoters, but also covers the genome at lower levels. Here, using inducible genetic perturbations and quantitative genomics, we discover that the BAP1 deubiquitylase plays an essential role in constraining H2AK119ub1 throughout the genome. Removal of BAP1 leads to pervasive accumulation of H2AK119ub1, which causes widespread reductions in gene expression. We show that elevated H2AK119ub1 represses gene expression by counteracting transcription initiation from gene regulatory elements, causing reductions in transcription-associated histone modifications. Furthermore, failure to constrain pervasive H2AK119ub1 compromises Polycomb complex occupancy at a subset of Polycomb target genes leading to their derepression, therefore explaining the original genetic characterisation of BAP1 as a Polycomb group gene. Together, these observations reveal that the transcriptional potential of the genome can be modulated by regulating the levels of a pervasive histone modification, without the need for elaborate gene-specific targeting mechanisms." @default.
- W3098678168 created "2020-11-23" @default.
- W3098678168 creator A5011779835 @default.
- W3098678168 creator A5034407668 @default.
- W3098678168 creator A5040874905 @default.
- W3098678168 creator A5045947531 @default.
- W3098678168 creator A5068227989 @default.
- W3098678168 creator A5076136267 @default.
- W3098678168 creator A5088836770 @default.
- W3098678168 date "2020-11-14" @default.
- W3098678168 modified "2023-10-18" @default.
- W3098678168 title "BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome" @default.
- W3098678168 cites W1540264737 @default.
- W3098678168 cites W1559859249 @default.
- W3098678168 cites W1828440160 @default.
- W3098678168 cites W1832882893 @default.
- W3098678168 cites W1874793893 @default.
- W3098678168 cites W1898469708 @default.
- W3098678168 cites W1931010989 @default.
- W3098678168 cites W1935585532 @default.
- W3098678168 cites W1967269362 @default.
- W3098678168 cites W1967769642 @default.
- W3098678168 cites W1973094248 @default.
- W3098678168 cites W1979513200 @default.
- W3098678168 cites W1979635179 @default.
- W3098678168 cites W1981516407 @default.
- W3098678168 cites W1982313259 @default.
- W3098678168 cites W1985925569 @default.
- W3098678168 cites W1986302429 @default.
- W3098678168 cites W1986586739 @default.
- W3098678168 cites W1989561383 @default.
- W3098678168 cites W1992213480 @default.
- W3098678168 cites W2006534695 @default.
- W3098678168 cites W2009166526 @default.
- W3098678168 cites W2011181841 @default.
- W3098678168 cites W2011192730 @default.
- W3098678168 cites W2011753829 @default.
- W3098678168 cites W2014677321 @default.
- W3098678168 cites W2014766736 @default.
- W3098678168 cites W2015132841 @default.
- W3098678168 cites W2015392617 @default.
- W3098678168 cites W2015416439 @default.
- W3098678168 cites W2017048095 @default.
- W3098678168 cites W2017625776 @default.
- W3098678168 cites W2017840637 @default.
- W3098678168 cites W2018363492 @default.
- W3098678168 cites W2018865924 @default.
- W3098678168 cites W2026873880 @default.
- W3098678168 cites W2026914820 @default.
- W3098678168 cites W2028003321 @default.
- W3098678168 cites W2032742580 @default.
- W3098678168 cites W2033890654 @default.
- W3098678168 cites W2037589637 @default.
- W3098678168 cites W2038235796 @default.
- W3098678168 cites W2042418635 @default.
- W3098678168 cites W2043071276 @default.
- W3098678168 cites W2044826047 @default.
- W3098678168 cites W2047143392 @default.
- W3098678168 cites W2051190311 @default.
- W3098678168 cites W2060870400 @default.
- W3098678168 cites W2062255596 @default.
- W3098678168 cites W2062357183 @default.
- W3098678168 cites W2064261519 @default.
- W3098678168 cites W2070359888 @default.
- W3098678168 cites W2070867144 @default.
- W3098678168 cites W2071818162 @default.
- W3098678168 cites W2072630073 @default.
- W3098678168 cites W2074474322 @default.
- W3098678168 cites W2075087486 @default.
- W3098678168 cites W2086958019 @default.
- W3098678168 cites W2089736373 @default.
- W3098678168 cites W2093800333 @default.
- W3098678168 cites W2095002834 @default.
- W3098678168 cites W2095111355 @default.
- W3098678168 cites W2095881412 @default.
- W3098678168 cites W2096083625 @default.
- W3098678168 cites W2097690067 @default.
- W3098678168 cites W2098952156 @default.
- W3098678168 cites W2102619694 @default.
- W3098678168 cites W2108196925 @default.
- W3098678168 cites W2108234281 @default.
- W3098678168 cites W2120100277 @default.
- W3098678168 cites W2120257529 @default.
- W3098678168 cites W2127015328 @default.
- W3098678168 cites W2127455821 @default.
- W3098678168 cites W2128016314 @default.
- W3098678168 cites W2128505445 @default.
- W3098678168 cites W2128551987 @default.
- W3098678168 cites W2129608054 @default.
- W3098678168 cites W2146497742 @default.
- W3098678168 cites W2147524392 @default.
- W3098678168 cites W2152983548 @default.
- W3098678168 cites W2154284135 @default.
- W3098678168 cites W2156518222 @default.
- W3098678168 cites W2158610627 @default.
- W3098678168 cites W2158789637 @default.
- W3098678168 cites W2161841622 @default.
- W3098678168 cites W2165894156 @default.
- W3098678168 cites W2165962849 @default.
- W3098678168 cites W2167315449 @default.