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- W3098706502 endingPage "104589" @default.
- W3098706502 startingPage "104589" @default.
- W3098706502 abstract "Diabetes and obesity is associated with change in the gut microbiota, however, the reason for such transition is still unknown. The secondary complications in diabetes mainly stem from protein glycation, oxidative stress and inflammatory response. It is intended to study the correlation between gut proteins glycation and microbial dysbiosis and thereby progression to diabetes. The study was carried out through feeding high fructose to male Wistar rats and evaluating their gut microbiota. The rate of gut flora excretion via faecal matter was found to decrease on fructose feed for 7 days. Intestinal flora was drastically reduced and pathogenic succession observed. Intestinal fluorescence studies confirmed that there is heavy glycation of gut proteins. Microbes obtained from fructose fed animals could grow on glycated BSA. There was significant increase in level of TNF-α and IFN-γ providing evidence of inflammation. Though microbial dysbiosis was observed in diabetes, the cause for this remained elusive. In the present study we prove that high fructose feed and glycation of the gut proteins probably prevent adherence/survival of the gut microflora in control animals and promotes transition to a changed microflora which is capable of adhering/utilizing glycated proteins as well as high fructose. The changed microbiota, enhanced protein glycation and inflammation help in establishing insulin resistance." @default.
- W3098706502 created "2020-11-23" @default.
- W3098706502 creator A5045620305 @default.
- W3098706502 creator A5060060029 @default.
- W3098706502 date "2021-03-01" @default.
- W3098706502 modified "2023-09-23" @default.
- W3098706502 title "Glycation of gut proteins initiates microbial dysbiosis and can promote establishment of diabetes in experimental animals" @default.
- W3098706502 cites W1442075714 @default.
- W3098706502 cites W1808650664 @default.
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- W3098706502 cites W1969062424 @default.
- W3098706502 cites W1971415551 @default.
- W3098706502 cites W1974768880 @default.
- W3098706502 cites W1978527143 @default.
- W3098706502 cites W1991147524 @default.
- W3098706502 cites W1991705455 @default.
- W3098706502 cites W1998353775 @default.
- W3098706502 cites W2005198341 @default.
- W3098706502 cites W2009596137 @default.
- W3098706502 cites W2022803290 @default.
- W3098706502 cites W2031352506 @default.
- W3098706502 cites W2037344497 @default.
- W3098706502 cites W2037948476 @default.
- W3098706502 cites W2046758691 @default.
- W3098706502 cites W2057455944 @default.
- W3098706502 cites W2063518823 @default.
- W3098706502 cites W2065461553 @default.
- W3098706502 cites W2071841602 @default.
- W3098706502 cites W2073332363 @default.
- W3098706502 cites W2073922963 @default.
- W3098706502 cites W2074465835 @default.
- W3098706502 cites W2075374205 @default.
- W3098706502 cites W2076193455 @default.
- W3098706502 cites W2082397710 @default.
- W3098706502 cites W2087816048 @default.
- W3098706502 cites W2089686249 @default.
- W3098706502 cites W2090458918 @default.
- W3098706502 cites W2092193084 @default.
- W3098706502 cites W2096146301 @default.
- W3098706502 cites W2097186016 @default.
- W3098706502 cites W2099427253 @default.
- W3098706502 cites W2102016788 @default.
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- W3098706502 cites W2104890139 @default.
- W3098706502 cites W2105860617 @default.
- W3098706502 cites W2107799920 @default.
- W3098706502 cites W2120685125 @default.
- W3098706502 cites W2121677860 @default.
- W3098706502 cites W2122454567 @default.
- W3098706502 cites W2126879017 @default.
- W3098706502 cites W2128060031 @default.
- W3098706502 cites W2130633090 @default.
- W3098706502 cites W2131536972 @default.
- W3098706502 cites W2135989088 @default.
- W3098706502 cites W2138411980 @default.
- W3098706502 cites W2143370576 @default.
- W3098706502 cites W2145738090 @default.
- W3098706502 cites W2147980059 @default.
- W3098706502 cites W2149573313 @default.
- W3098706502 cites W2150046185 @default.
- W3098706502 cites W2151476184 @default.
- W3098706502 cites W2151960003 @default.
- W3098706502 cites W2153075279 @default.
- W3098706502 cites W2153456263 @default.
- W3098706502 cites W2158714788 @default.
- W3098706502 cites W2161262662 @default.
- W3098706502 cites W2256668945 @default.
- W3098706502 cites W2330078859 @default.
- W3098706502 cites W2344809720 @default.
- W3098706502 cites W2345789205 @default.
- W3098706502 cites W2501745162 @default.
- W3098706502 cites W2530535175 @default.
- W3098706502 cites W2588579982 @default.
- W3098706502 cites W2590621413 @default.
- W3098706502 cites W2619124175 @default.
- W3098706502 cites W2621726600 @default.
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- W3098706502 cites W2762664203 @default.
- W3098706502 cites W2799524357 @default.
- W3098706502 cites W2800099492 @default.
- W3098706502 cites W2802461797 @default.
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- W3098706502 cites W2965916141 @default.
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- W3098706502 doi "https://doi.org/10.1016/j.micpath.2020.104589" @default.
- W3098706502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33171259" @default.
- W3098706502 hasPublicationYear "2021" @default.
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