Matches in SemOpenAlex for { <https://semopenalex.org/work/W3098707918> ?p ?o ?g. }
- W3098707918 abstract "ABSTRACT Previous studies have shown that translation elongation is regulated by multiple factors, but the observed heterogeneity remains only partially explained. To dissect quantitatively the different determinants of elongation speed, we use probabilistic modeling to estimate initiation and local elongation rates from ribosome profiling data. This model-based approach allows us to quantify the extent of interference between ribosomes on the same transcript. We show that neither interference nor the distribution of slow codons is sufficient to explain the observed heterogeneity. Instead, we find that electrostatic interactions between the ribosomal exit tunnel and specific parts of the nascent polypeptide govern the elongation rate variation as the polypeptide makes its initial pass through the tunnel. Once the N-terminus has escaped the tunnel, the hydropathy of the nascent polypeptide within the ribosome plays a major role in modulating the speed. We show that our results are consistent with the biophysical properties of the tunnel." @default.
- W3098707918 created "2020-11-23" @default.
- W3098707918 creator A5012430778 @default.
- W3098707918 creator A5050837693 @default.
- W3098707918 date "2016-12-01" @default.
- W3098707918 modified "2023-09-25" @default.
- W3098707918 title "The impact of ribosomal interference, codon usage, and exit tunnel interactions on translation elongation rate variation" @default.
- W3098707918 cites W1196894603 @default.
- W3098707918 cites W1543796220 @default.
- W3098707918 cites W1561855928 @default.
- W3098707918 cites W1956613997 @default.
- W3098707918 cites W1964330084 @default.
- W3098707918 cites W1973268693 @default.
- W3098707918 cites W1973364414 @default.
- W3098707918 cites W1975304761 @default.
- W3098707918 cites W1981473906 @default.
- W3098707918 cites W1984468703 @default.
- W3098707918 cites W1985818080 @default.
- W3098707918 cites W1988092390 @default.
- W3098707918 cites W1993358499 @default.
- W3098707918 cites W1997809760 @default.
- W3098707918 cites W2011503994 @default.
- W3098707918 cites W2012456489 @default.
- W3098707918 cites W2020138003 @default.
- W3098707918 cites W2020445568 @default.
- W3098707918 cites W2020663470 @default.
- W3098707918 cites W2025569664 @default.
- W3098707918 cites W2026076714 @default.
- W3098707918 cites W2029226109 @default.
- W3098707918 cites W2029582401 @default.
- W3098707918 cites W2038598202 @default.
- W3098707918 cites W2047405192 @default.
- W3098707918 cites W2051242197 @default.
- W3098707918 cites W2057015366 @default.
- W3098707918 cites W2058852389 @default.
- W3098707918 cites W2060101754 @default.
- W3098707918 cites W2060421156 @default.
- W3098707918 cites W2070605140 @default.
- W3098707918 cites W2071849521 @default.
- W3098707918 cites W2075487771 @default.
- W3098707918 cites W2078734278 @default.
- W3098707918 cites W2079517684 @default.
- W3098707918 cites W2086157203 @default.
- W3098707918 cites W2086344973 @default.
- W3098707918 cites W2094338137 @default.
- W3098707918 cites W2105762369 @default.
- W3098707918 cites W2107804881 @default.
- W3098707918 cites W2108926259 @default.
- W3098707918 cites W2115875921 @default.
- W3098707918 cites W2116831267 @default.
- W3098707918 cites W2120368500 @default.
- W3098707918 cites W2122836610 @default.
- W3098707918 cites W2124565600 @default.
- W3098707918 cites W2125672968 @default.
- W3098707918 cites W2126096918 @default.
- W3098707918 cites W2129178024 @default.
- W3098707918 cites W2147837708 @default.
- W3098707918 cites W2155147384 @default.
- W3098707918 cites W2156492795 @default.
- W3098707918 cites W2160215304 @default.
- W3098707918 cites W2160656989 @default.
- W3098707918 cites W2162170988 @default.
- W3098707918 cites W2163223478 @default.
- W3098707918 cites W2170513170 @default.
- W3098707918 cites W2175136759 @default.
- W3098707918 cites W2223861440 @default.
- W3098707918 cites W2259283565 @default.
- W3098707918 cites W2288379959 @default.
- W3098707918 cites W2412562549 @default.
- W3098707918 cites W2500465292 @default.
- W3098707918 cites W2513858144 @default.
- W3098707918 cites W2520675467 @default.
- W3098707918 cites W2529618169 @default.
- W3098707918 cites W2581130118 @default.
- W3098707918 cites W2582445098 @default.
- W3098707918 cites W2603991019 @default.
- W3098707918 cites W2793056129 @default.
- W3098707918 cites W2950711038 @default.
- W3098707918 cites W3104022573 @default.
- W3098707918 cites W4213265037 @default.
- W3098707918 doi "https://doi.org/10.1101/090837" @default.
- W3098707918 hasPublicationYear "2016" @default.
- W3098707918 type Work @default.
- W3098707918 sameAs 3098707918 @default.
- W3098707918 citedByCount "2" @default.
- W3098707918 countsByYear W30987079182017 @default.
- W3098707918 countsByYear W30987079182018 @default.
- W3098707918 crossrefType "posted-content" @default.
- W3098707918 hasAuthorship W3098707918A5012430778 @default.
- W3098707918 hasAuthorship W3098707918A5050837693 @default.
- W3098707918 hasBestOaLocation W30987079181 @default.
- W3098707918 hasConcept C104317684 @default.
- W3098707918 hasConcept C105580179 @default.
- W3098707918 hasConcept C112950240 @default.
- W3098707918 hasConcept C12554922 @default.
- W3098707918 hasConcept C149364088 @default.
- W3098707918 hasConcept C182325514 @default.
- W3098707918 hasConcept C186060115 @default.
- W3098707918 hasConcept C191897082 @default.
- W3098707918 hasConcept C192562407 @default.