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• W3098806366 abstract "Significance Production of IL-1β is an essential component of the inflammatory response and host defense. IL-1β secretion is dependent on the activation of an intracellular platform termed inflammasome. The initial inflammatory signals that drive inflammasome activation remains elusive. Here, we show that the bioactive lipid leukotriene B 4 enhances both transcriptional and posttranscriptional programs that activate the inflammasome in vivo and in vitro. We identified critical signaling programs required for inflammasome assembly, IL-1β secretion, and its consequences in skin host defense. Our data also suggest that the prevention of LTB 4 actions might be an important therapeutic strategy to prevent IL-1β–dependent inflammatory diseases by inhibiting both first and second signals necessary for inflammasome activation." @default.
• W3098806366 created "2020-11-23" @default.
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• W3098806366 date "2020-11-12" @default.
• W3098806366 modified "2023-10-17" @default.
• W3098806366 title "Leukotriene B ₄ licenses inflammasome activation to enhance skin host defense" @default.
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• W3098806366 doi "https://doi.org/10.1073/pnas.2002732117" @default.
• W3098806366 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7720147" @default.
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