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- W3098819683 endingPage "113015" @default.
- W3098819683 startingPage "113015" @default.
- W3098819683 abstract "Modulation of interactome networks, essentially protein-protein interactions (PPIs), might represent valuable therapeutic approaches to different pathological conditions. Since a high percentage of PPIs are mediated by α-helical structures at the interacting surface, the development of compounds able to reproduce the amino acid side-chain organization of α-helices (e.g. stabilized α-helix peptides and β-derivatives, proteomimetics, and α-helix small-molecule mimetics) focuses the attention of different research groups. This appraisal describes the recent progress in the non-peptide α-helix mimetics field, which has evolved from single-face to multi-face reproducing compounds and from oligomeric to monomeric scaffolds able to bear different substituents in similar spatial dispositions as the side-chains in canonical helices. Grouped by chemical structures, the review contemplates terphenyl-like molecules, oligobenzamides and heterocyclic analogues, benzamide-amino acid conjugates and non-oligomeric small-molecules mimetics, among others, and their effectiveness to stabilize/disrupt therapeutically relevant PPIs. The X-ray structures of a couple of oligomeric peptidomimetics and of some small-molecules complexed with the MDM2 protein, as well as the state of the art on their development in clinical trials, are also remarked. The discovery of a continuously increasing number of new disease-relevant PPIs could offer future opportunities for these and other forthcoming α-helix mimetics." @default.
- W3098819683 created "2020-11-23" @default.
- W3098819683 creator A5001281124 @default.
- W3098819683 creator A5024317398 @default.
- W3098819683 creator A5083885349 @default.
- W3098819683 date "2021-02-01" @default.
- W3098819683 modified "2023-10-18" @default.
- W3098819683 title "Evolution in non-peptide α-helix mimetics on the road to effective protein-protein interaction modulators" @default.
- W3098819683 cites W1199549464 @default.
- W3098819683 cites W1604125332 @default.
- W3098819683 cites W1818336382 @default.
- W3098819683 cites W1851613051 @default.
- W3098819683 cites W1913278027 @default.
- W3098819683 cites W1957068985 @default.
- W3098819683 cites W1971261623 @default.
- W3098819683 cites W1972765844 @default.
- W3098819683 cites W1978786071 @default.
- W3098819683 cites W1978924350 @default.
- W3098819683 cites W1988004949 @default.
- W3098819683 cites W1993591356 @default.
- W3098819683 cites W1994626016 @default.
- W3098819683 cites W1997703216 @default.
- W3098819683 cites W2000880755 @default.
- W3098819683 cites W2001172519 @default.
- W3098819683 cites W2001728855 @default.
- W3098819683 cites W2003768436 @default.
- W3098819683 cites W2005171216 @default.
- W3098819683 cites W2005293003 @default.
- W3098819683 cites W2007411604 @default.
- W3098819683 cites W2010890545 @default.
- W3098819683 cites W2011424390 @default.
- W3098819683 cites W2012799867 @default.
- W3098819683 cites W2018221677 @default.
- W3098819683 cites W2019261511 @default.
- W3098819683 cites W2034483767 @default.
- W3098819683 cites W2038555943 @default.
- W3098819683 cites W2041626757 @default.
- W3098819683 cites W2045881502 @default.
- W3098819683 cites W2051455181 @default.
- W3098819683 cites W2051485239 @default.
- W3098819683 cites W2054791285 @default.
- W3098819683 cites W2056283033 @default.
- W3098819683 cites W2060828304 @default.
- W3098819683 cites W2067837994 @default.
- W3098819683 cites W2072220895 @default.
- W3098819683 cites W2072817540 @default.
- W3098819683 cites W2079828864 @default.
- W3098819683 cites W2080687645 @default.
- W3098819683 cites W2087574732 @default.
- W3098819683 cites W2087945165 @default.
- W3098819683 cites W2092139560 @default.
- W3098819683 cites W2092549818 @default.
- W3098819683 cites W2093018678 @default.
- W3098819683 cites W2094251756 @default.
- W3098819683 cites W2097933346 @default.
- W3098819683 cites W2100968572 @default.
- W3098819683 cites W2123355212 @default.
- W3098819683 cites W2135579845 @default.
- W3098819683 cites W2136646067 @default.
- W3098819683 cites W2142350160 @default.
- W3098819683 cites W2143188324 @default.
- W3098819683 cites W2144252975 @default.
- W3098819683 cites W2148132056 @default.
- W3098819683 cites W2151785803 @default.
- W3098819683 cites W2153691089 @default.
- W3098819683 cites W2154382529 @default.
- W3098819683 cites W2155996499 @default.
- W3098819683 cites W2157977328 @default.
- W3098819683 cites W2164316626 @default.
- W3098819683 cites W2192371490 @default.
- W3098819683 cites W2211210052 @default.
- W3098819683 cites W2218618885 @default.
- W3098819683 cites W2261452124 @default.
- W3098819683 cites W2277797998 @default.
- W3098819683 cites W2278828177 @default.
- W3098819683 cites W2300566088 @default.
- W3098819683 cites W2330002776 @default.
- W3098819683 cites W2331882936 @default.
- W3098819683 cites W2335098315 @default.
- W3098819683 cites W2340621314 @default.
- W3098819683 cites W2466965536 @default.
- W3098819683 cites W2508895628 @default.
- W3098819683 cites W2538051933 @default.
- W3098819683 cites W2553739816 @default.
- W3098819683 cites W2557432935 @default.
- W3098819683 cites W2589302592 @default.
- W3098819683 cites W2592741283 @default.
- W3098819683 cites W2600231982 @default.
- W3098819683 cites W2613095572 @default.
- W3098819683 cites W2765251968 @default.
- W3098819683 cites W2772414450 @default.
- W3098819683 cites W2791013977 @default.
- W3098819683 cites W2797607794 @default.
- W3098819683 cites W2800544241 @default.
- W3098819683 cites W2805563063 @default.
- W3098819683 cites W2887168173 @default.
- W3098819683 cites W2888626191 @default.
- W3098819683 cites W2890631528 @default.