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• W3098921536 abstract "Abstract Overexposure to intense noise can destroy the synapses between auditory nerve fibers and their hair cell targets without destroying the hair cells themselves. In adult mice, this synaptopathy is immediate and largely irreversible, whereas, in guinea pigs, counts of immunostained synaptic puncta can recover with increasing post-exposure survival. Here, we asked whether this recovery simply reflects changes in synaptic immunostaining, or whether there is actual retraction and extension of neurites and/or synaptogenesis. Analysis of the numbers, sizes and spatial distribution of pre- and post-synaptic markers on cochlear inner hair cells, in guinea pigs surviving from 1 day to 6 months after a synaptopathic exposure, shows dramatic synaptic re-organization during the recovery period in which synapse counts recover from 16 to 91% of normal in the most affected regions. Synaptic puncta move all over the hair cell membrane during recovery, translocating far from their normal positions at the basolateral pole, and auditory-nerve terminals extend towards the hair cell’s apical end to re-establish contact with them. These observations provide stronger evidence for spontaneous neural regeneration in a mature mammalian cochlea than can be inferred from synaptic counts alone." @default.
• W3098921536 created "2020-11-23" @default.
• W3098921536 creator A5013597034 @default.
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• W3098921536 date "2020-11-17" @default.
• W3098921536 modified "2023-10-16" @default.
• W3098921536 title "Synaptic migration and reorganization after noise exposure suggests regeneration in a mature mammalian cochlea" @default.
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• W3098921536 doi "https://doi.org/10.1038/s41598-020-76553-w" @default.
• W3098921536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7672098" @default.
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• W3098921536 hasPublicationYear "2020" @default.
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