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• W3098929480 abstract "Abstract We previously showed that each dog with chronic non-invasive sino-nasal aspergillosis (SNA) was infected with a single genotype of Aspergillus fumigatus . Here, we studied the transcriptome of this fungal pathogen and the canine host within the biofilm resulting from the infection. We describe here transcriptomes resulting from natural infections in animal species with A. fumigatus . The host transcriptome showed high expression of IL-8 and alarmins, uncontrolled inflammatory reaction and dysregulation of the Th17 response. The fungal transcriptome showed in particular expression of genes involved in secondary metabolites and nutrient acquisition. Single-nucleotide polymorphism analysis of fungal isolates from the biofilms showed large genetic variability and changes related with adaptation to host environmental factors. This was accompanied with large phenotypic variability in in vitro stress assays, even between isolates from the same canine patient. Our analysis provides insights in genetic and phenotypic variability of Aspergillus fumigatus in biofilms of naturally infected dogs reflecting in-host adaptation. Absence of a Th17 response and dampening of the Th1 response contributes to the formation of a chronic sino-nasal warzone." @default.
• W3098929480 created "2020-11-23" @default.
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• W3098929480 date "2020-11-12" @default.
• W3098929480 modified "2023-10-14" @default.
• W3098929480 title "The sino-nasal warzone: transcriptomic and genomic studies on sino-nasal aspergillosis in dogs" @default.
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• W3098929480 doi "https://doi.org/10.1038/s41522-020-00163-7" @default.
• W3098929480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7665010" @default.
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