FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3099039973> ?p ?o ?g. }

• W3099039973 endingPage "105173" @default.
• W3099039973 startingPage "105173" @default.
• W3099039973 abstract "Lafora disease (LD) is a fatal adolescence-onset neurodegenerative condition. The hallmark of LD is the accumulation of aberrant glycogen aggregates called Lafora bodies (LBs) in the brain and other tissues. Impeding glycogen synthesis from early embryonic stages by genetic suppression of glycogen synthase (MGS) in an animal model of LD prevents LB formation and ultimately the pathological manifestations of LD thereby indicating that LBs are responsible for the pathophysiology of the disease. However, it is not clear whether eliminating glycogen synthesis in an adult animal after LBs have already formed would halt or reverse the progression of LD. Herein we generated a mouse model of LD with inducible MGS suppression. We evaluated the effect of MGS suppression at different time points on LB accumulation as well as on the appearance of neuroinflammation, a pathologic trait of LD models. In the skeletal muscle, MGS suppression in adult LD mice blocked the formation of new LBs and reduced the number of glycogen aggregates. In the brain, early but not late MGS suppression halted the accumulation of LBs. However, the neuroinflammatory response was still present, as shown by the levels of reactive astrocytes, microglia and inflammatory cytokines. Our results confirm that MGS as a promising therapeutic target for LD and highlight the importance of an early diagnosis for effective treatment of the disease." @default.
• W3099039973 created "2020-11-23" @default.
• W3099039973 creator A5002567533 @default.
• W3099039973 creator A5009450911 @default.
• W3099039973 creator A5031347216 @default.
• W3099039973 creator A5036882732 @default.
• W3099039973 creator A5081716853 @default.
• W3099039973 date "2021-01-01" @default.
• W3099039973 modified "2023-10-18" @default.
• W3099039973 title "Suppression of glycogen synthesis as a treatment for Lafora disease: Establishing the window of opportunity" @default.
• W3099039973 cites W1900548871 @default.
• W3099039973 cites W1916893403 @default.
• W3099039973 cites W1983314236 @default.
• W3099039973 cites W2008871433 @default.
• W3099039973 cites W2023272535 @default.
• W3099039973 cites W2027361915 @default.
• W3099039973 cites W2046991618 @default.
• W3099039973 cites W2052102985 @default.
• W3099039973 cites W2057334342 @default.
• W3099039973 cites W2075234503 @default.
• W3099039973 cites W2093476689 @default.
• W3099039973 cites W2097287826 @default.
• W3099039973 cites W2104504339 @default.
• W3099039973 cites W2109015289 @default.
• W3099039973 cites W2114440563 @default.
• W3099039973 cites W2118393368 @default.
• W3099039973 cites W2126722763 @default.
• W3099039973 cites W2131872983 @default.
• W3099039973 cites W2140357048 @default.
• W3099039973 cites W2153524819 @default.
• W3099039973 cites W2159267296 @default.
• W3099039973 cites W2166010463 @default.
• W3099039973 cites W2340549461 @default.
• W3099039973 cites W2745415858 @default.
• W3099039973 cites W2749457599 @default.
• W3099039973 cites W2789489194 @default.
• W3099039973 cites W2792857412 @default.
• W3099039973 cites W2888224568 @default.
• W3099039973 cites W2888918396 @default.
• W3099039973 cites W2895843447 @default.
• W3099039973 cites W2952481429 @default.
• W3099039973 cites W2983604978 @default.
• W3099039973 cites W2994375543 @default.
• W3099039973 cites W3009739339 @default.
• W3099039973 doi "https://doi.org/10.1016/j.nbd.2020.105173" @default.
• W3099039973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7736642" @default.
• W3099039973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33171226" @default.
• W3099039973 hasPublicationYear "2021" @default.
• W3099039973 type Work @default.
• W3099039973 sameAs 3099039973 @default.
• W3099039973 citedByCount "18" @default.
• W3099039973 countsByYear W30990399732021 @default.
• W3099039973 countsByYear W30990399732022 @default.
• W3099039973 countsByYear W30990399732023 @default.
• W3099039973 crossrefType "journal-article" @default.
• W3099039973 hasAuthorship W3099039973A5002567533 @default.
• W3099039973 hasAuthorship W3099039973A5009450911 @default.
• W3099039973 hasAuthorship W3099039973A5031347216 @default.
• W3099039973 hasAuthorship W3099039973A5036882732 @default.
• W3099039973 hasAuthorship W3099039973A5081716853 @default.
• W3099039973 hasBestOaLocation W30990399731 @default.
• W3099039973 hasConcept C104317684 @default.
• W3099039973 hasConcept C11960822 @default.
• W3099039973 hasConcept C127716648 @default.
• W3099039973 hasConcept C134018914 @default.
• W3099039973 hasConcept C169760540 @default.
• W3099039973 hasConcept C178666793 @default.
• W3099039973 hasConcept C192118531 @default.
• W3099039973 hasConcept C203014093 @default.
• W3099039973 hasConcept C2776914184 @default.
• W3099039973 hasConcept C2777280662 @default.
• W3099039973 hasConcept C2777499176 @default.
• W3099039973 hasConcept C2779830541 @default.
• W3099039973 hasConcept C54355233 @default.
• W3099039973 hasConcept C86803240 @default.
• W3099039973 hasConcept C87753298 @default.
• W3099039973 hasConcept C95444343 @default.
• W3099039973 hasConceptScore W3099039973C104317684 @default.
• W3099039973 hasConceptScore W3099039973C11960822 @default.
• W3099039973 hasConceptScore W3099039973C127716648 @default.
• W3099039973 hasConceptScore W3099039973C134018914 @default.
• W3099039973 hasConceptScore W3099039973C169760540 @default.
• W3099039973 hasConceptScore W3099039973C178666793 @default.
• W3099039973 hasConceptScore W3099039973C192118531 @default.
• W3099039973 hasConceptScore W3099039973C203014093 @default.
• W3099039973 hasConceptScore W3099039973C2776914184 @default.
• W3099039973 hasConceptScore W3099039973C2777280662 @default.
• W3099039973 hasConceptScore W3099039973C2777499176 @default.
• W3099039973 hasConceptScore W3099039973C2779830541 @default.
• W3099039973 hasConceptScore W3099039973C54355233 @default.
• W3099039973 hasConceptScore W3099039973C86803240 @default.
• W3099039973 hasConceptScore W3099039973C87753298 @default.
• W3099039973 hasConceptScore W3099039973C95444343 @default.
• W3099039973 hasFunder F4320322930 @default.
• W3099039973 hasFunder F4320332161 @default.
• W3099039973 hasLocation W30990399731 @default.
• W3099039973 hasLocation W30990399732 @default.
• W3099039973 hasLocation W30990399733 @default.

• next