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• W3099092309 abstract "The problem of selecting one action from a set of different possible actions, simply referred to as the problem of action selection, is a ubiquitous challenge in the animal world. For vertebrates, the basal ganglia (BG) are widely thought to implement the core computation to solve this problem, as the anatomy and physiology of the BG are well-suited to this end. However, the BG still displays physiological features whose role in achieving efficient action selection remains unclear. In particular, it is known that the two types of dopaminergic receptors (D1 and D2) present in the BG give rise to mechanistically different responses. The overall effect will be a difference in sensitivity to dopamine which may have ramifications for action selection. However, which receptor type leads to a stronger response is, a priori, unclear, due to the complexity of the intracellular mechanisms involved. In this study, we use the action selection hypothesis to {em predict} which of D1 or D2 has the greater sensitivity. Thus, we ask - what sensitivity ratio would result in enhanced action selection functionality in the basal ganglia? To do this, we incorporated differential D1 and D2 sensitivity in an existing, high level computational model of the macro-architecture of the basal ganglia, via a simple weighting variable. We then quantitatively assessed the model's capacity to perform action selection as we parametrically manipulated the new feature. We show that differential (rather than equal) D1 and D2 sensitivity to dopaminergic input improves action selection, and specifically, that greater D1 sensitivity (compared to that for D2) leads to these improvements." @default.
• W3099092309 created "2020-11-23" @default.
• W3099092309 creator A5044806170 @default.
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• W3099092309 date "2020-11-12" @default.
• W3099092309 modified "2023-10-15" @default.
• W3099092309 title "Differential dopamine receptor-dependent sensitivity improves action selection in the basal ganglia" @default.
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• W3099092309 doi "https://doi.org/10.1101/2020.11.12.380451" @default.
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