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• W3099102518 abstract "Abstract Selective pressures imposed by pathogens have varied among human populations throughout their evolution, leading to marked inter-population differences at some genes mediating susceptibility to infectious and immune-related diseases. A common polymorphism resulting in a C 529 versus T 529 change in the Cadherin-Related Family Member 3 ( CDHR3 ) receptor is associated with rhinovirus-C (RV-C) susceptibility and severe childhood asthma. Given the morbidity and mortality associated with RV-C dependent respiratory infections and asthma, we hypothesized that the protective variant has been under selection in the human population. Supporting this idea, a recent cross-species outbreak of RV-C among chimpanzees in Uganda, which carry the ancestral ‘risk’ allele at this position, resulted in a mortality rate of 8.9%. Using publicly available genomic data, we sought to determine the evolutionary history and role of selection acting on this infectious disease susceptibility locus. The protective variant is the derived allele and is found at high frequency worldwide, with the lowest relative frequency in African populations and highest in East Asian populations. There is minimal population structure among haplotypes, and we detect genomic signatures consistent with a rapid increase in frequency of the protective allele across all human populations. However, given strong evidence that the protective allele arose in anatomically modern humans prior to their migrations out of Africa and that the allele has not fixed in any population, the patterns observed here are not consistent with a classical selective sweep. We hypothesize that patterns may indicate frequency-dependent selection worldwide. Irrespective of the mode of selection, our analyses show the derived allele has been subject to selection in recent human evolution." @default.
• W3099102518 created "2020-11-23" @default.
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• W3099102518 date "2017-09-08" @default.
• W3099102518 modified "2023-09-23" @default.
• W3099102518 title "A Complex Evolutionary History for the Disease Susceptibility CDHR3 Locus" @default.
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• W3099102518 doi "https://doi.org/10.1101/186031" @default.
• W3099102518 hasPublicationYear "2017" @default.
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