FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W30991610> ?p ?o ?g. }

• W30991610 endingPage "1101" @default.
• W30991610 startingPage "1095" @default.
• W30991610 abstract "Our aim was to assess whether a higher clopidogrel maintenance dose has a greater antiplatelet effect in CYP2C19*2 allele carriers compared with noncarriers.Clopidogrel is a prodrug that is biotransformed by the cytochrome P450 enzymes CYP2C19, 2C9, and 3A4, 2B6, 1A2. The CYPC219*2 loss of function variant has been associated with a reduced antiplatelet response to clopidogrel and a 3-fold risk of stent thrombosis.Forty patients on standard maintenance dosage clopidogrel (75 mg), for 9.4 +/- 9.2 weeks, were enrolled into a dose escalation study. Platelet function was assessed at baseline and after 1 week of 150 mg once daily using the VerifyNow platelet function analyzer (Accumetrics Ltd., San Diego, California). Genomic DNA was hybridized to a BioFilmChip microarray on the INFINITI analyzer (AutoGenomics Inc., Carlsbad, California) and analyzed for the CYP19*2, *4, *17, and CYP2C9*2, *3 polymorphisms.Platelet inhibition increased over 1 week, mean +8.6 +/- 13.5% (p = 0.0003). Carriers of the CYP2C19*2 allele had significantly reduced platelet inhibition at baseline (median 18%, range 0% to 72%) compared with wildtype (wt) (median 59%, range 11% to 95%, p = 0.01) and at 1 week (p = 0.03). CYP2C19*2 allele carriers had an increase in platelet inhibition of (mean +9 +/- 11%, p = 0.03) and reduction in platelet reactivity (mean -26 +/- 38 platelet response unit, p = 0.04) with a higher dose. Together CYP2C19*2 and CYP2C9*3 loss of function carriers had a greater change in platelet inhibition with 150 mg daily than wt/wt (+10.9% vs. +0.7%, p = 0.04).Increasing the dose of clopidogrel in patients with nonresponder polymorphisms can increase antiplatelet response. Personalizing clopidogrel dosing using pharmacogenomics may be an effective method of optimizing treatment." @default.
• W30991610 created "2016-06-24" @default.
• W30991610 creator A5002935320 @default.
• W30991610 creator A5031815634 @default.
• W30991610 creator A5039205205 @default.
• W30991610 creator A5040709108 @default.
• W30991610 creator A5040801997 @default.
• W30991610 creator A5043375132 @default.
• W30991610 creator A5056753463 @default.
• W30991610 creator A5057269334 @default.
• W30991610 creator A5062843291 @default.
• W30991610 creator A5089306105 @default.
• W30991610 date "2009-11-01" @default.
• W30991610 modified "2023-10-14" @default.
• W30991610 title "Pharmacogenetic Testing for Clopidogrel Using the Rapid INFINITI Analyzer" @default.
• W30991610 cites W109410924 @default.
• W30991610 cites W110195037 @default.
• W30991610 cites W1409766979 @default.
• W30991610 cites W177698552 @default.
• W30991610 cites W1965018592 @default.
• W30991610 cites W1973551591 @default.
• W30991610 cites W1976577625 @default.
• W30991610 cites W1985059672 @default.
• W30991610 cites W2007108997 @default.
• W30991610 cites W2007251996 @default.
• W30991610 cites W2039397816 @default.
• W30991610 cites W2044845122 @default.
• W30991610 cites W2076350004 @default.
• W30991610 cites W2076472818 @default.
• W30991610 cites W2081224653 @default.
• W30991610 cites W2096069261 @default.
• W30991610 cites W2105005467 @default.
• W30991610 cites W2113311913 @default.
• W30991610 cites W2113926891 @default.
• W30991610 cites W2119951798 @default.
• W30991610 cites W2120603250 @default.
• W30991610 cites W2140220482 @default.
• W30991610 cites W2143777566 @default.
• W30991610 cites W2146453185 @default.
• W30991610 cites W2149238031 @default.
• W30991610 cites W2149774429 @default.
• W30991610 cites W2156177625 @default.
• W30991610 cites W2157065952 @default.
• W30991610 cites W2158389123 @default.
• W30991610 cites W2159858918 @default.
• W30991610 cites W2163125822 @default.
• W30991610 cites W2163166957 @default.
• W30991610 cites W2163961571 @default.
• W30991610 cites W2169387542 @default.
• W30991610 cites W2170125927 @default.
• W30991610 doi "https://doi.org/10.1016/j.jcin.2009.08.018" @default.
• W30991610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19926050" @default.
• W30991610 hasPublicationYear "2009" @default.
• W30991610 type Work @default.
• W30991610 sameAs 30991610 @default.
• W30991610 citedByCount "49" @default.
• W30991610 countsByYear W309916102012 @default.
• W30991610 countsByYear W309916102013 @default.
• W30991610 countsByYear W309916102014 @default.
• W30991610 countsByYear W309916102015 @default.
• W30991610 countsByYear W309916102016 @default.
• W30991610 countsByYear W309916102017 @default.
• W30991610 countsByYear W309916102018 @default.
• W30991610 countsByYear W309916102020 @default.
• W30991610 countsByYear W309916102023 @default.
• W30991610 crossrefType "journal-article" @default.
• W30991610 hasAuthorship W30991610A5002935320 @default.
• W30991610 hasAuthorship W30991610A5031815634 @default.
• W30991610 hasAuthorship W30991610A5039205205 @default.
• W30991610 hasAuthorship W30991610A5040709108 @default.
• W30991610 hasAuthorship W30991610A5040801997 @default.
• W30991610 hasAuthorship W30991610A5043375132 @default.
• W30991610 hasAuthorship W30991610A5056753463 @default.
• W30991610 hasAuthorship W30991610A5057269334 @default.
• W30991610 hasAuthorship W30991610A5062843291 @default.
• W30991610 hasAuthorship W30991610A5089306105 @default.
• W30991610 hasBestOaLocation W309916101 @default.
• W30991610 hasConcept C126322002 @default.
• W30991610 hasConcept C140840227 @default.
• W30991610 hasConcept C2777628954 @default.
• W30991610 hasConcept C2777849778 @default.
• W30991610 hasConcept C3946865 @default.
• W30991610 hasConcept C526171541 @default.
• W30991610 hasConcept C62231903 @default.
• W30991610 hasConcept C71924100 @default.
• W30991610 hasConcept C89560881 @default.
• W30991610 hasConcept C90924648 @default.
• W30991610 hasConcept C98274493 @default.
• W30991610 hasConceptScore W30991610C126322002 @default.
• W30991610 hasConceptScore W30991610C140840227 @default.
• W30991610 hasConceptScore W30991610C2777628954 @default.
• W30991610 hasConceptScore W30991610C2777849778 @default.
• W30991610 hasConceptScore W30991610C3946865 @default.
• W30991610 hasConceptScore W30991610C526171541 @default.
• W30991610 hasConceptScore W30991610C62231903 @default.
• W30991610 hasConceptScore W30991610C71924100 @default.
• W30991610 hasConceptScore W30991610C89560881 @default.
• W30991610 hasConceptScore W30991610C90924648 @default.

• next