FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3099267910> ?p ?o ?g. }

• W3099267910 endingPage "8587" @default.
• W3099267910 startingPage "8587" @default.
• W3099267910 abstract "The aim of this study is to explore the role of microRNAs (miR)-21/23a/146a/150/155 targeting the toll-like receptor pathway in active tuberculosis (TB) disease and latent TB infection (LTBI). Gene expression levels of the five miRs and predicted target genes were assessed in peripheral blood mononuclear cells from 46 patients with active pulmonary TB, 15 subjects with LTBI, and 17 non-infected healthy subjects (NIHS). THP-1 cell lines were transfected with miR-23a-3p mimics under stimuli with Mycobacterium TB-specific antigens. Both miR-155-5p and miR-150-5p gene expressions were decreased in the active TB group versus the NIHS group. Both miR-23a-3p and miR-146a-5p gene expressions were decreased in active TB patients with high bacterial burden versus those with low bacterial burden or control group (LTBI + NIHS). TLR2, TLR4, and interleukin (IL)10 gene expressions were all increased in active TB versus NIHS group. MiR-23a-3p mimic transfection reversed ESAT6-induced reduction of reactive oxygen species generation, and augmented ESAT6-induced late apoptosis and phagocytosis, in association with down-regulations of the predicted target genes, including tumor necrosis factor (TNF)-α, TLR4, TLR2, IL6, IL10, Notch1, IL6R, BCL2, TGF-β1, SP1, and IRF1. In conclusion, the down-regulation of miR-23a-3p in active TB patients with high bacterial burden inhibited mononuclear cell function and phagocytosis through TLR4/TNF-α/TGF-β1/IL-10 signaling via targeting IRF1/SP1." @default.
• W3099267910 created "2020-11-23" @default.
• W3099267910 creator A5017116368 @default.
• W3099267910 creator A5032616174 @default.
• W3099267910 creator A5035493464 @default.
• W3099267910 creator A5045062726 @default.
• W3099267910 creator A5061790462 @default.
• W3099267910 creator A5066405298 @default.
• W3099267910 creator A5067500993 @default.
• W3099267910 creator A5067728021 @default.
• W3099267910 creator A5088729333 @default.
• W3099267910 date "2020-11-14" @default.
• W3099267910 modified "2023-09-27" @default.
• W3099267910 title "MicroRNA-23a-3p Down-Regulation in Active Pulmonary Tuberculosis Patients with High Bacterial Burden Inhibits Mononuclear Cell Function and Phagocytosis through TLR4/TNF-α/TGF-β1/IL-10 Signaling via Targeting IRF1/SP1" @default.
• W3099267910 cites W1982487153 @default.
• W3099267910 cites W2037432461 @default.
• W3099267910 cites W2043867255 @default.
• W3099267910 cites W2053091684 @default.
• W3099267910 cites W2065230752 @default.
• W3099267910 cites W2078609256 @default.
• W3099267910 cites W2079166304 @default.
• W3099267910 cites W2085823870 @default.
• W3099267910 cites W2086419629 @default.
• W3099267910 cites W2089095281 @default.
• W3099267910 cites W2089449281 @default.
• W3099267910 cites W2097583307 @default.
• W3099267910 cites W2133418861 @default.
• W3099267910 cites W2143049557 @default.
• W3099267910 cites W2148186218 @default.
• W3099267910 cites W2152451121 @default.
• W3099267910 cites W2178316435 @default.
• W3099267910 cites W2259684562 @default.
• W3099267910 cites W2275470695 @default.
• W3099267910 cites W2277947619 @default.
• W3099267910 cites W2315200953 @default.
• W3099267910 cites W2315299788 @default.
• W3099267910 cites W2412832086 @default.
• W3099267910 cites W2438973494 @default.
• W3099267910 cites W2499616866 @default.
• W3099267910 cites W2526398540 @default.
• W3099267910 cites W2546856805 @default.
• W3099267910 cites W2595696306 @default.
• W3099267910 cites W2607604684 @default.
• W3099267910 cites W2622204177 @default.
• W3099267910 cites W2755532538 @default.
• W3099267910 cites W2756349126 @default.
• W3099267910 cites W2788443790 @default.
• W3099267910 cites W2794518950 @default.
• W3099267910 cites W2803132334 @default.
• W3099267910 cites W2887956262 @default.
• W3099267910 cites W2888434709 @default.
• W3099267910 cites W2897921822 @default.
• W3099267910 cites W2899239524 @default.
• W3099267910 cites W2903723297 @default.
• W3099267910 cites W2908304277 @default.
• W3099267910 cites W2936424538 @default.
• W3099267910 cites W2948117492 @default.
• W3099267910 cites W2953086657 @default.
• W3099267910 cites W2997560844 @default.
• W3099267910 cites W3024985532 @default.
• W3099267910 cites W873455898 @default.
• W3099267910 cites W2594974254 @default.
• W3099267910 doi "https://doi.org/10.3390/ijms21228587" @default.
• W3099267910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7697976" @default.
• W3099267910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33202583" @default.
• W3099267910 hasPublicationYear "2020" @default.
• W3099267910 type Work @default.
• W3099267910 sameAs 3099267910 @default.
• W3099267910 citedByCount "10" @default.
• W3099267910 countsByYear W30992679102021 @default.
• W3099267910 countsByYear W30992679102022 @default.
• W3099267910 countsByYear W30992679102023 @default.
• W3099267910 crossrefType "journal-article" @default.
• W3099267910 hasAuthorship W3099267910A5017116368 @default.
• W3099267910 hasAuthorship W3099267910A5032616174 @default.
• W3099267910 hasAuthorship W3099267910A5035493464 @default.
• W3099267910 hasAuthorship W3099267910A5045062726 @default.
• W3099267910 hasAuthorship W3099267910A5061790462 @default.
• W3099267910 hasAuthorship W3099267910A5066405298 @default.
• W3099267910 hasAuthorship W3099267910A5067500993 @default.
• W3099267910 hasAuthorship W3099267910A5067728021 @default.
• W3099267910 hasAuthorship W3099267910A5088729333 @default.
• W3099267910 hasBestOaLocation W30992679101 @default.
• W3099267910 hasConcept C104317684 @default.
• W3099267910 hasConcept C137061746 @default.
• W3099267910 hasConcept C160448771 @default.
• W3099267910 hasConcept C17991360 @default.
• W3099267910 hasConcept C187316574 @default.
• W3099267910 hasConcept C202751555 @default.
• W3099267910 hasConcept C203014093 @default.
• W3099267910 hasConcept C2776070231 @default.
• W3099267910 hasConcept C2776914184 @default.
• W3099267910 hasConcept C2778690821 @default.
• W3099267910 hasConcept C2781236682 @default.
• W3099267910 hasConcept C502942594 @default.
• W3099267910 hasConcept C54009773 @default.
• W3099267910 hasConcept C55493867 @default.
• W3099267910 hasConcept C71924100 @default.

• next