Matches in SemOpenAlex for { <https://semopenalex.org/work/W3099291212> ?p ?o ?g. }
- W3099291212 endingPage "8387" @default.
- W3099291212 startingPage "8387" @default.
- W3099291212 abstract "Tumor suppressor p53 plays a key role in tumor suppression. In addition to tumor suppression, p53 is also involved in many other biological and pathological processes, such as immune response, maternal reproduction, tissue ischemia/reperfusion injuries and neurodegenerative diseases. While it has been widely accepted that the role of p53 in regulation of cell cycle arrest, senescence and apoptosis contributes greatly to the function of p53 in tumor suppression, emerging evidence has implicated that p53 also exerts its tumor suppressive function through regulation of many other cellular processes, such as metabolism, anti-oxidant defense and ferroptosis. Ferroptosis is a unique iron-dependent form of programmed cell death driven by lipid peroxidation in cells. Ferroptosis has been reported to be involved in cancer, tissue ischemia/reperfusion injuries and neurodegenerative diseases. Recent studies have shown that ferroptosis can be regulated by p53 and its signaling pathway as well as tumor-associated mutant p53. Interestingly, the regulation of ferroptosis by p53 appears to be highly context-dependent. In this review, we summarize recent advances in the regulation of ferroptosis by p53 and its signaling pathway. Further elucidation of the role and molecular mechanism of p53 in ferroptosis regulation will yield new therapeutic strategies for cancer and other diseases, including neurodegenerative diseases and tissue ischemia/reperfusion injuries." @default.
- W3099291212 created "2020-11-23" @default.
- W3099291212 creator A5017058735 @default.
- W3099291212 creator A5044463543 @default.
- W3099291212 creator A5052713292 @default.
- W3099291212 creator A5066337255 @default.
- W3099291212 creator A5080125836 @default.
- W3099291212 date "2020-11-09" @default.
- W3099291212 modified "2023-10-11" @default.
- W3099291212 title "The Regulation of Ferroptosis by Tumor Suppressor p53 and its Pathway" @default.
- W3099291212 cites W1483486462 @default.
- W3099291212 cites W1580865462 @default.
- W3099291212 cites W1589007430 @default.
- W3099291212 cites W1596431542 @default.
- W3099291212 cites W1977394099 @default.
- W3099291212 cites W1985271346 @default.
- W3099291212 cites W1988194175 @default.
- W3099291212 cites W1989834424 @default.
- W3099291212 cites W1992648442 @default.
- W3099291212 cites W1995068068 @default.
- W3099291212 cites W1995185113 @default.
- W3099291212 cites W1997183854 @default.
- W3099291212 cites W2002490399 @default.
- W3099291212 cites W2004628001 @default.
- W3099291212 cites W2020230298 @default.
- W3099291212 cites W2023599593 @default.
- W3099291212 cites W2028953339 @default.
- W3099291212 cites W2035898183 @default.
- W3099291212 cites W2038652783 @default.
- W3099291212 cites W2044418897 @default.
- W3099291212 cites W2045171661 @default.
- W3099291212 cites W2055811314 @default.
- W3099291212 cites W2057632732 @default.
- W3099291212 cites W2058194275 @default.
- W3099291212 cites W2062976534 @default.
- W3099291212 cites W2067107606 @default.
- W3099291212 cites W2069448970 @default.
- W3099291212 cites W2069452349 @default.
- W3099291212 cites W2073824759 @default.
- W3099291212 cites W2074892323 @default.
- W3099291212 cites W2075188232 @default.
- W3099291212 cites W2081184407 @default.
- W3099291212 cites W2081949499 @default.
- W3099291212 cites W2083659501 @default.
- W3099291212 cites W2089101049 @default.
- W3099291212 cites W2095916340 @default.
- W3099291212 cites W2101821132 @default.
- W3099291212 cites W2114138419 @default.
- W3099291212 cites W2116374020 @default.
- W3099291212 cites W2116991069 @default.
- W3099291212 cites W2125910222 @default.
- W3099291212 cites W2133959309 @default.
- W3099291212 cites W2135458195 @default.
- W3099291212 cites W2138217484 @default.
- W3099291212 cites W2140844543 @default.
- W3099291212 cites W2150007817 @default.
- W3099291212 cites W2155124667 @default.
- W3099291212 cites W2158477153 @default.
- W3099291212 cites W2162262059 @default.
- W3099291212 cites W2162420845 @default.
- W3099291212 cites W2163005196 @default.
- W3099291212 cites W2180777157 @default.
- W3099291212 cites W2204004844 @default.
- W3099291212 cites W2204583106 @default.
- W3099291212 cites W2265062179 @default.
- W3099291212 cites W2295554976 @default.
- W3099291212 cites W2303171964 @default.
- W3099291212 cites W2305753128 @default.
- W3099291212 cites W2327775625 @default.
- W3099291212 cites W2328976566 @default.
- W3099291212 cites W2336651814 @default.
- W3099291212 cites W2374069442 @default.
- W3099291212 cites W2400474752 @default.
- W3099291212 cites W2503851771 @default.
- W3099291212 cites W2510683099 @default.
- W3099291212 cites W2513656923 @default.
- W3099291212 cites W2518357275 @default.
- W3099291212 cites W2519497098 @default.
- W3099291212 cites W2527907612 @default.
- W3099291212 cites W2529409645 @default.
- W3099291212 cites W2549188196 @default.
- W3099291212 cites W2550324626 @default.
- W3099291212 cites W2561384038 @default.
- W3099291212 cites W2568082326 @default.
- W3099291212 cites W2583631769 @default.
- W3099291212 cites W2593130667 @default.
- W3099291212 cites W2595206365 @default.
- W3099291212 cites W2599031841 @default.
- W3099291212 cites W2601818643 @default.
- W3099291212 cites W2604481254 @default.
- W3099291212 cites W2605051147 @default.
- W3099291212 cites W2618536534 @default.
- W3099291212 cites W2727828415 @default.
- W3099291212 cites W2739378577 @default.
- W3099291212 cites W2745256990 @default.
- W3099291212 cites W2745520112 @default.
- W3099291212 cites W2745891591 @default.
- W3099291212 cites W2752942423 @default.