FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3099385540> ?p ?o ?g. }

• W3099385540 endingPage "485.e5" @default.
• W3099385540 startingPage "473" @default.
• W3099385540 abstract "Sequential temporal ordering and patterning are key features of natural signals, used by the brain to decode stimuli and perceive them as sensory objects. To explore how cortical neuronal activity underpins sequence discrimination, we developed a task in which mice distinguished between tactile word sequences constructed from distinct vibrations delivered to the whiskers, assembled in different orders. Animals licked to report the presence of the target sequence. Mice could respond to the earliest possible cues allowing discrimination, effectively solving the task as a detection of change problem, but enhanced their performance when responding later. Optogenetic inactivation showed that the somatosensory cortex was necessary for sequence discrimination. Two-photon imaging in layer 2/3 of the primary somatosensory barrel cortex (S1bf) revealed that, in well-trained animals, neurons had heterogeneous selectivity to multiple task variables including not just sensory input but also the animal's action decision and the trial outcome (presence or absence of the predicted reward). Many neurons were activated preceding goal-directed licking, thus reflecting the animal's learned action in response to the target sequence; these neurons were found as soon as mice learned to associate the rewarded sequence with licking. In contrast, learning evoked smaller changes in sensory response tuning: neurons responding to stimulus features were found in naive mice, and training did not generate neurons with enhanced temporal integration or categorical responses. Therefore, in S1bf, sequence learning results in neurons whose activity reflects the learned association between target sequence and licking rather than a refined representation of sensory features." @default.
• W3099385540 created "2020-11-23" @default.
• W3099385540 creator A5006226637 @default.
• W3099385540 creator A5020798729 @default.
• W3099385540 creator A5039819263 @default.
• W3099385540 creator A5071359955 @default.
• W3099385540 creator A5091739399 @default.
• W3099385540 date "2021-02-01" @default.
• W3099385540 modified "2023-09-25" @default.
• W3099385540 title "Sequence Learning Induces Selectivity to Multiple Task Parameters in Mouse Somatosensory Cortex" @default.
• W3099385540 cites W1480668978 @default.
• W3099385540 cites W1538429890 @default.
• W3099385540 cites W1654207600 @default.
• W3099385540 cites W1934472280 @default.
• W3099385540 cites W1964049834 @default.
• W3099385540 cites W1964314167 @default.
• W3099385540 cites W1967731411 @default.
• W3099385540 cites W1969271050 @default.
• W3099385540 cites W1972869628 @default.
• W3099385540 cites W1986790148 @default.
• W3099385540 cites W1987864047 @default.
• W3099385540 cites W1996889564 @default.
• W3099385540 cites W1998104411 @default.
• W3099385540 cites W1999324548 @default.
• W3099385540 cites W2000869512 @default.
• W3099385540 cites W2001383746 @default.
• W3099385540 cites W2001830985 @default.
• W3099385540 cites W2002667643 @default.
• W3099385540 cites W2003958121 @default.
• W3099385540 cites W2007815184 @default.
• W3099385540 cites W2009410694 @default.
• W3099385540 cites W2011973215 @default.
• W3099385540 cites W2021271087 @default.
• W3099385540 cites W2025607482 @default.
• W3099385540 cites W2027898593 @default.
• W3099385540 cites W2028740998 @default.
• W3099385540 cites W2032838376 @default.
• W3099385540 cites W2033708181 @default.
• W3099385540 cites W2037820041 @default.
• W3099385540 cites W2039611165 @default.
• W3099385540 cites W2040165511 @default.
• W3099385540 cites W2040387081 @default.
• W3099385540 cites W2040707073 @default.
• W3099385540 cites W2040802571 @default.
• W3099385540 cites W2041321054 @default.
• W3099385540 cites W2043426395 @default.
• W3099385540 cites W2047125104 @default.
• W3099385540 cites W2047637126 @default.
• W3099385540 cites W2051781198 @default.
• W3099385540 cites W2059746123 @default.
• W3099385540 cites W2067405710 @default.
• W3099385540 cites W2073272844 @default.
• W3099385540 cites W2075312701 @default.
• W3099385540 cites W2076168055 @default.
• W3099385540 cites W2086578108 @default.
• W3099385540 cites W2086871516 @default.
• W3099385540 cites W2087297596 @default.
• W3099385540 cites W2088729932 @default.
• W3099385540 cites W2088955805 @default.
• W3099385540 cites W2092511662 @default.
• W3099385540 cites W2100366622 @default.
• W3099385540 cites W2104069712 @default.
• W3099385540 cites W2104071396 @default.
• W3099385540 cites W2105867118 @default.
• W3099385540 cites W2118344162 @default.
• W3099385540 cites W2124634979 @default.
• W3099385540 cites W2124992632 @default.
• W3099385540 cites W2126766602 @default.
• W3099385540 cites W2128585328 @default.
• W3099385540 cites W2134827085 @default.
• W3099385540 cites W2137259486 @default.
• W3099385540 cites W2144494088 @default.
• W3099385540 cites W2147698153 @default.
• W3099385540 cites W2148086499 @default.
• W3099385540 cites W2149158842 @default.
• W3099385540 cites W2154658047 @default.
• W3099385540 cites W2164591549 @default.
• W3099385540 cites W2167279371 @default.
• W3099385540 cites W2171302127 @default.
• W3099385540 cites W2171332611 @default.
• W3099385540 cites W2180251131 @default.
• W3099385540 cites W2190199438 @default.
• W3099385540 cites W2211009999 @default.
• W3099385540 cites W2221344439 @default.
• W3099385540 cites W2398733530 @default.
• W3099385540 cites W2416119024 @default.
• W3099385540 cites W2467233121 @default.
• W3099385540 cites W2481900801 @default.
• W3099385540 cites W2482462198 @default.
• W3099385540 cites W2512650568 @default.
• W3099385540 cites W2537955564 @default.
• W3099385540 cites W2604805728 @default.
• W3099385540 cites W2616012590 @default.
• W3099385540 cites W2616734028 @default.
• W3099385540 cites W2617276037 @default.
• W3099385540 cites W2733704258 @default.
• W3099385540 cites W2737989178 @default.
• W3099385540 cites W2749209136 @default.

• next