FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3099395934> ?p ?o ?g. }

• W3099395934 endingPage "169" @default.
• W3099395934 startingPage "156" @default.
• W3099395934 abstract "The neurotoxin 1-methyl, 4-phenyl, 1, 2, 3, 6-tetrahydropiridine (MPTP) is widely used to produce experimental parkinsonism. Such a disease is characterized by neuronal damage in multiple regions beyond the nigrostriatal pathway including the spinal cord. The neurotoxin MPTP damages spinal motor neurons. So far, in Parkinson's disease (PD) patients alpha-synuclein aggregates are described in the dorsal horn of the spinal cord. Nonetheless, no experimental investigation was carried out to document whether MPTP affects the sensory compartment of the spinal cord. Thus, in the present study, we investigated whether chronic exposure to small doses of MPTP (5 mg/kg/X2, daily, for 21 days) produces any pathological effect within dorsal spinal cord. This mild neurotoxic protocol produces a damage only to nigrostriatal dopamine (DA) axon terminals with no decrease in DA nigral neurons assessed by quantitative stereology. In these experimental conditions we documented a decrease in enkephalin-, calretinin-, calbindin D28K-, and parvalbumin-positive neurons within lamina I and II and the outer lamina III. Met-Enkephalin and substance P positive fibers are reduced in laminae I and II of chronically MPTP-treated mice. In contrast, as reported in PD patients, alpha-synuclein is markedly increased within spared neurons and fibers of lamina I and II after MPTP exposure. This is the first evidence that experimental parkinsonism produces the loss of specific neurons of the dorsal spinal cord, which are likely to be involved in sensory transmission and in pain modulation providing an experimental correlate for sensory and pain alterations in PD." @default.
• W3099395934 created "2020-11-23" @default.
• W3099395934 creator A5002731112 @default.
• W3099395934 creator A5005660426 @default.
• W3099395934 creator A5029383304 @default.
• W3099395934 creator A5032981915 @default.
• W3099395934 creator A5046002870 @default.
• W3099395934 creator A5054427807 @default.
• W3099395934 creator A5060955984 @default.
• W3099395934 creator A5066072593 @default.
• W3099395934 creator A5089494044 @default.
• W3099395934 date "2020-11-18" @default.
• W3099395934 modified "2023-09-26" @default.
• W3099395934 title "Chronic MPTP in Mice Damage-specific Neuronal Phenotypes within Dorsal Laminae of the Spinal Cord" @default.
• W3099395934 cites W1483007279 @default.
• W3099395934 cites W1496850081 @default.
• W3099395934 cites W1553433790 @default.
• W3099395934 cites W175006040 @default.
• W3099395934 cites W1966962735 @default.
• W3099395934 cites W1969751124 @default.
• W3099395934 cites W1973030684 @default.
• W3099395934 cites W1973392168 @default.
• W3099395934 cites W1976087525 @default.
• W3099395934 cites W1976946357 @default.
• W3099395934 cites W1979685086 @default.
• W3099395934 cites W1984294395 @default.
• W3099395934 cites W1984325684 @default.
• W3099395934 cites W1984380776 @default.
• W3099395934 cites W1992826589 @default.
• W3099395934 cites W2004558157 @default.
• W3099395934 cites W2005631666 @default.
• W3099395934 cites W2007654607 @default.
• W3099395934 cites W2014779151 @default.
• W3099395934 cites W2020462265 @default.
• W3099395934 cites W2022834361 @default.
• W3099395934 cites W2022911097 @default.
• W3099395934 cites W2031928416 @default.
• W3099395934 cites W2036210278 @default.
• W3099395934 cites W2041734419 @default.
• W3099395934 cites W2045812316 @default.
• W3099395934 cites W2047691740 @default.
• W3099395934 cites W2053026848 @default.
• W3099395934 cites W2054887564 @default.
• W3099395934 cites W2055437008 @default.
• W3099395934 cites W2056189993 @default.
• W3099395934 cites W2059084497 @default.
• W3099395934 cites W2061340270 @default.
• W3099395934 cites W2084733306 @default.
• W3099395934 cites W2086208850 @default.
• W3099395934 cites W2088590019 @default.
• W3099395934 cites W2089183987 @default.
• W3099395934 cites W2089289079 @default.
• W3099395934 cites W2106012506 @default.
• W3099395934 cites W2111405228 @default.
• W3099395934 cites W2111682630 @default.
• W3099395934 cites W2114148333 @default.
• W3099395934 cites W2128672762 @default.
• W3099395934 cites W2146222688 @default.
• W3099395934 cites W2147574090 @default.
• W3099395934 cites W2149793745 @default.
• W3099395934 cites W2169382112 @default.
• W3099395934 cites W2253949321 @default.
• W3099395934 cites W2295106086 @default.
• W3099395934 cites W2407714607 @default.
• W3099395934 cites W2418954344 @default.
• W3099395934 cites W2621775373 @default.
• W3099395934 cites W2763305669 @default.
• W3099395934 cites W2788833165 @default.
• W3099395934 cites W2794189368 @default.
• W3099395934 cites W2799765287 @default.
• W3099395934 cites W2800339537 @default.
• W3099395934 cites W2805954533 @default.
• W3099395934 cites W2806540278 @default.
• W3099395934 cites W2905008707 @default.
• W3099395934 cites W2940404939 @default.
• W3099395934 cites W2983314294 @default.
• W3099395934 cites W2988909879 @default.
• W3099395934 cites W4211044101 @default.
• W3099395934 cites W4300542969 @default.
• W3099395934 doi "https://doi.org/10.1007/s12640-020-00313-x" @default.
• W3099395934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7936970" @default.
• W3099395934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33206341" @default.
• W3099395934 hasPublicationYear "2020" @default.
• W3099395934 type Work @default.
• W3099395934 sameAs 3099395934 @default.
• W3099395934 citedByCount "8" @default.
• W3099395934 countsByYear W30993959342021 @default.
• W3099395934 countsByYear W30993959342022 @default.
• W3099395934 countsByYear W30993959342023 @default.
• W3099395934 crossrefType "journal-article" @default.
• W3099395934 hasAuthorship W3099395934A5002731112 @default.
• W3099395934 hasAuthorship W3099395934A5005660426 @default.
• W3099395934 hasAuthorship W3099395934A5029383304 @default.
• W3099395934 hasAuthorship W3099395934A5032981915 @default.
• W3099395934 hasAuthorship W3099395934A5046002870 @default.
• W3099395934 hasAuthorship W3099395934A5054427807 @default.
• W3099395934 hasAuthorship W3099395934A5060955984 @default.
• W3099395934 hasAuthorship W3099395934A5066072593 @default.

• next