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• W3099440246 startingPage "951" @default.
• W3099440246 abstract "The influenza A virus is a human pathogen causing respiratory infections. The ability of this virus to trigger seasonal epidemics and sporadic pandemics is a result of its high genetic variability, leading to the ineffectiveness of vaccinations and current therapies. The source of this variability is the accumulation of mutations in viral genes and reassortment enabled by its segmented genome. The latter process can induce major changes and the production of new strains with pandemic potential. However, not all genetic combinations are tolerated and lead to the assembly of complete infectious virions. Reports have shown that viral RNA segments co-segregate in particular circumstances. This tendency is a consequence of the complex and selective genome packaging process, which takes place in the final stages of the viral replication cycle. It has been shown that genome packaging is governed by RNA-RNA interactions. Intersegment contacts create a network, characterized by the presence of common and strain-specific interaction sites. Recent studies have revealed certain RNA regions, and conserved secondary structure motifs within them, which may play functional roles in virion assembly. Growing knowledge on RNA structure and interactions facilitates our understanding of the appearance of new genome variants, and may allow for the prediction of potential reassortment outcomes and the emergence of new strains in the future." @default.
• W3099440246 created "2020-11-23" @default.
• W3099440246 creator A5010668582 @default.
• W3099440246 creator A5062909838 @default.
• W3099440246 creator A5085241168 @default.
• W3099440246 date "2020-11-15" @default.
• W3099440246 modified "2023-09-26" @default.
• W3099440246 title "Organization of the Influenza A Virus Genomic RNA in the Viral Replication Cycle—Structure, Interactions, and Implications for the Emergence of New Strains" @default.
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• W3099440246 doi "https://doi.org/10.3390/pathogens9110951" @default.
• W3099440246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7696059" @default.
• W3099440246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33203084" @default.
• W3099440246 hasPublicationYear "2020" @default.
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