Matches in SemOpenAlex for { <https://semopenalex.org/work/W3099457670> ?p ?o ?g. }
- W3099457670 abstract "Abstract During affinity maturation, germinal center (GC) B cells alternate between proliferation and so-matic hypermutation in the dark zone (DZ) and affinity-dependent selection in the light zone (LZ). This anatomical segregation imposes that the vigorous proliferation that allows clonal expansion of positively-selected GC B cells takes place ostensibly in the absence of the signals that triggered selection in the LZ, as if by “inertia.” We find that such inertial cycles specifically require the cell cycle regulator cyclin D3. Cyclin D3 dose-dependently controls the extent to which B cells proliferate in the DZ and is essential for effective clonal expansion of GC B cells in response to strong T follicular helper (Tfh) cell help. Introduction into the Ccnd3 gene of a Burkitt lymphoma-associated gain-of-function mutation (T283A) leads to larger GCs with increased DZ proliferation and, in older mice, to clonal B cell lymphoproliferation, suggesting that the DZ inertial cell cycle program can be coopted by B cells undergoing malignant transformation." @default.
- W3099457670 created "2020-11-23" @default.
- W3099457670 creator A5016183751 @default.
- W3099457670 creator A5019770989 @default.
- W3099457670 creator A5024162635 @default.
- W3099457670 creator A5026476694 @default.
- W3099457670 creator A5031964366 @default.
- W3099457670 creator A5035443892 @default.
- W3099457670 creator A5049050329 @default.
- W3099457670 creator A5061307976 @default.
- W3099457670 creator A5063622901 @default.
- W3099457670 creator A5070357517 @default.
- W3099457670 creator A5072162720 @default.
- W3099457670 creator A5077994933 @default.
- W3099457670 creator A5083743078 @default.
- W3099457670 date "2020-11-17" @default.
- W3099457670 modified "2023-10-17" @default.
- W3099457670 title "Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells" @default.
- W3099457670 cites W107174851 @default.
- W3099457670 cites W1526404082 @default.
- W3099457670 cites W1681312898 @default.
- W3099457670 cites W1835395435 @default.
- W3099457670 cites W1977237743 @default.
- W3099457670 cites W1978153385 @default.
- W3099457670 cites W1991497659 @default.
- W3099457670 cites W1996435746 @default.
- W3099457670 cites W1999574084 @default.
- W3099457670 cites W2005327717 @default.
- W3099457670 cites W2013557916 @default.
- W3099457670 cites W2016054852 @default.
- W3099457670 cites W2016175731 @default.
- W3099457670 cites W2018110741 @default.
- W3099457670 cites W2020330574 @default.
- W3099457670 cites W2031263707 @default.
- W3099457670 cites W2052465225 @default.
- W3099457670 cites W2065782380 @default.
- W3099457670 cites W2069590838 @default.
- W3099457670 cites W2070012169 @default.
- W3099457670 cites W2071380288 @default.
- W3099457670 cites W2089655089 @default.
- W3099457670 cites W2092627057 @default.
- W3099457670 cites W2098675621 @default.
- W3099457670 cites W2118028844 @default.
- W3099457670 cites W2123106337 @default.
- W3099457670 cites W2123561809 @default.
- W3099457670 cites W2129509656 @default.
- W3099457670 cites W2130410032 @default.
- W3099457670 cites W2132323963 @default.
- W3099457670 cites W2139676849 @default.
- W3099457670 cites W2140754284 @default.
- W3099457670 cites W2144449731 @default.
- W3099457670 cites W2145025639 @default.
- W3099457670 cites W2148531397 @default.
- W3099457670 cites W2150178760 @default.
- W3099457670 cites W2150938787 @default.
- W3099457670 cites W2160762238 @default.
- W3099457670 cites W2169456326 @default.
- W3099457670 cites W2170039745 @default.
- W3099457670 cites W2277351499 @default.
- W3099457670 cites W2303546457 @default.
- W3099457670 cites W2332292689 @default.
- W3099457670 cites W2509655738 @default.
- W3099457670 cites W2521741241 @default.
- W3099457670 cites W2578371477 @default.
- W3099457670 cites W2614850398 @default.
- W3099457670 cites W2665840216 @default.
- W3099457670 cites W2683294477 @default.
- W3099457670 cites W2755038050 @default.
- W3099457670 cites W2787240390 @default.
- W3099457670 cites W2920840557 @default.
- W3099457670 cites W2938678047 @default.
- W3099457670 cites W2946701636 @default.
- W3099457670 cites W2949177718 @default.
- W3099457670 cites W2962936545 @default.
- W3099457670 cites W2997280954 @default.
- W3099457670 cites W3004359693 @default.
- W3099457670 cites W3014743289 @default.
- W3099457670 cites W4246504300 @default.
- W3099457670 cites W4251633039 @default.
- W3099457670 doi "https://doi.org/10.1101/2020.11.17.385716" @default.
- W3099457670 hasPublicationYear "2020" @default.
- W3099457670 type Work @default.
- W3099457670 sameAs 3099457670 @default.
- W3099457670 citedByCount "1" @default.
- W3099457670 countsByYear W30994576702022 @default.
- W3099457670 crossrefType "posted-content" @default.
- W3099457670 hasAuthorship W3099457670A5016183751 @default.
- W3099457670 hasAuthorship W3099457670A5019770989 @default.
- W3099457670 hasAuthorship W3099457670A5024162635 @default.
- W3099457670 hasAuthorship W3099457670A5026476694 @default.
- W3099457670 hasAuthorship W3099457670A5031964366 @default.
- W3099457670 hasAuthorship W3099457670A5035443892 @default.
- W3099457670 hasAuthorship W3099457670A5049050329 @default.
- W3099457670 hasAuthorship W3099457670A5061307976 @default.
- W3099457670 hasAuthorship W3099457670A5063622901 @default.
- W3099457670 hasAuthorship W3099457670A5070357517 @default.
- W3099457670 hasAuthorship W3099457670A5072162720 @default.
- W3099457670 hasAuthorship W3099457670A5077994933 @default.
- W3099457670 hasAuthorship W3099457670A5083743078 @default.
- W3099457670 hasBestOaLocation W30994576701 @default.