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- W3099498157 abstract "Galectin-3 binding protein (Gal-3BP) is one of the major fucosylated glycoprotein family members and has recently been implicated in non-alcoholic fatty liver disease, hyperlipaemia and coronary artery disease. Here, we analysed the serum concentrations of Gal-3BP in menopausal women to evaluate the association of circulating Gal-3BP and insulin resistance in females after menopause. We evaluated serum levels of Gal-3BP in sixty-two non-diabetic women with menopausal status for at least one year. The clinical features, biochemical profiles and homeostasis model assessment of insulin resistance (HOMA-IR) indices were obtained routinely. Gal-3BP levels increased in women with higher HOMA-IR indices and were positively correlated with HOMA-IR indices. The Gal-3BP level was also an independent risk factor for a high HOMA-IR index and showed the most influence on the HOMA-IR index compared to fasting plasma glucose, triglyceride, age and body mass index. The cut-off value of the serum Gal-3BP level was 2234.32 ng/ml, with areas under the ROC curve (AUCs) of 0.68 (HOMA-IR index 1.5), 0.81 (HOMA-IR index 2.0) and 0.93 (HOMA-IR index 2.5). Serum levels of Gal-3BP are associated with impaired insulin sensitivity in non-diabetic menopausal women." @default.
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- W3099498157 date "2020-11-01" @default.
- W3099498157 modified "2023-10-16" @default.
- W3099498157 title "Elevated serum levels of galectin-3 binding protein are associated with insulin resistance in non-diabetic women after menopause" @default.
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- W3099498157 doi "https://doi.org/10.1016/j.tjog.2020.09.014" @default.
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