Matches in SemOpenAlex for { <https://semopenalex.org/work/W3099527124> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3099527124 endingPage "832" @default.
- W3099527124 startingPage "832" @default.
- W3099527124 abstract "Infections with bacterial biofilm communities are highly tolerant of antibiotics. This protection is attributed, in part, to a hydrated extracellular polymeric substance (EPS) that surrounds the bacterial community and that limits antibiotic diffusion. In this study, we evaluated whether it is possible to dehydrate and then re-hydrate a biofilm as a means to increase antibiotic penetration and efficacy. Acinetobacter baumannii biofilms (24 h) were exposed to hypertonic concentrations of maltodextrin, sucrose or polyethylene glycol (PEG) as the dehydration step. These biofilms were then washed with deionized water containing 10 times the concentration of antibiotics needed to kill these bacteria in broth culture (50 µg/mL tobramycin, 300 µg/mL chloramphenicol, 20 µg/mL ciprofloxacin or 100 µg/mL erythromycin) as the rehydration step. Biofilms were then harvested, and the number of viable cells was determined. Sequential treatment with PEG and tobramycin reduced cell counts 4 to 7 log (p < 0.05) relative to combining PEG and tobramycin in a single treatment, and 3 to 7 log relative to tobramycin treatment alone (p < 0.05). Results were variable for other osmotic compounds and antibiotics depending on the concentrations used, likely related to mass and hydrophobicity. Our findings support future clinical evaluation of sequential regimens of hypertonic and hypotonic solutions to enhance antibiotic efficacy against chronic biofilm infections." @default.
- W3099527124 created "2020-11-23" @default.
- W3099527124 creator A5014481056 @default.
- W3099527124 creator A5047740126 @default.
- W3099527124 creator A5085802392 @default.
- W3099527124 date "2020-11-21" @default.
- W3099527124 modified "2023-09-30" @default.
- W3099527124 title "Sequential Hypertonic-Hypotonic Treatment Enhances Efficacy of Antibiotic against Acinetobacter baumannii Biofilm Communities" @default.
- W3099527124 cites W1854012211 @default.
- W3099527124 cites W1969179300 @default.
- W3099527124 cites W1999124243 @default.
- W3099527124 cites W2001703603 @default.
- W3099527124 cites W2006881751 @default.
- W3099527124 cites W2025932672 @default.
- W3099527124 cites W2052130550 @default.
- W3099527124 cites W2070300719 @default.
- W3099527124 cites W2078606044 @default.
- W3099527124 cites W2098448308 @default.
- W3099527124 cites W2101830519 @default.
- W3099527124 cites W2105847762 @default.
- W3099527124 cites W2112510458 @default.
- W3099527124 cites W2113115497 @default.
- W3099527124 cites W2114510377 @default.
- W3099527124 cites W2118355092 @default.
- W3099527124 cites W2132963724 @default.
- W3099527124 cites W2149746113 @default.
- W3099527124 cites W2159435953 @default.
- W3099527124 cites W2164841185 @default.
- W3099527124 cites W2466645477 @default.
- W3099527124 cites W2603755876 @default.
- W3099527124 cites W2606104114 @default.
- W3099527124 cites W2737388949 @default.
- W3099527124 cites W2793399175 @default.
- W3099527124 cites W2950861476 @default.
- W3099527124 cites W90645064 @default.
- W3099527124 doi "https://doi.org/10.3390/antibiotics9110832" @default.
- W3099527124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7700435" @default.
- W3099527124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33233331" @default.
- W3099527124 hasPublicationYear "2020" @default.
- W3099527124 type Work @default.
- W3099527124 sameAs 3099527124 @default.
- W3099527124 citedByCount "4" @default.
- W3099527124 countsByYear W30995271242021 @default.
- W3099527124 countsByYear W30995271242022 @default.
- W3099527124 crossrefType "journal-article" @default.
- W3099527124 hasAuthorship W3099527124A5014481056 @default.
- W3099527124 hasAuthorship W3099527124A5047740126 @default.
- W3099527124 hasAuthorship W3099527124A5085802392 @default.
- W3099527124 hasBestOaLocation W30995271241 @default.
- W3099527124 hasConcept C117277713 @default.
- W3099527124 hasConcept C185592680 @default.
- W3099527124 hasConcept C2775832221 @default.
- W3099527124 hasConcept C2776315533 @default.
- W3099527124 hasConcept C2777637488 @default.
- W3099527124 hasConcept C2778523567 @default.
- W3099527124 hasConcept C2778974779 @default.
- W3099527124 hasConcept C501593827 @default.
- W3099527124 hasConcept C523546767 @default.
- W3099527124 hasConcept C54355233 @default.
- W3099527124 hasConcept C55493867 @default.
- W3099527124 hasConcept C58123911 @default.
- W3099527124 hasConcept C86803240 @default.
- W3099527124 hasConcept C89423630 @default.
- W3099527124 hasConceptScore W3099527124C117277713 @default.
- W3099527124 hasConceptScore W3099527124C185592680 @default.
- W3099527124 hasConceptScore W3099527124C2775832221 @default.
- W3099527124 hasConceptScore W3099527124C2776315533 @default.
- W3099527124 hasConceptScore W3099527124C2777637488 @default.
- W3099527124 hasConceptScore W3099527124C2778523567 @default.
- W3099527124 hasConceptScore W3099527124C2778974779 @default.
- W3099527124 hasConceptScore W3099527124C501593827 @default.
- W3099527124 hasConceptScore W3099527124C523546767 @default.
- W3099527124 hasConceptScore W3099527124C54355233 @default.
- W3099527124 hasConceptScore W3099527124C55493867 @default.
- W3099527124 hasConceptScore W3099527124C58123911 @default.
- W3099527124 hasConceptScore W3099527124C86803240 @default.
- W3099527124 hasConceptScore W3099527124C89423630 @default.
- W3099527124 hasIssue "11" @default.
- W3099527124 hasLocation W30995271241 @default.
- W3099527124 hasLocation W30995271242 @default.
- W3099527124 hasLocation W30995271243 @default.
- W3099527124 hasOpenAccess W3099527124 @default.
- W3099527124 hasPrimaryLocation W30995271241 @default.
- W3099527124 hasRelatedWork W1809326518 @default.
- W3099527124 hasRelatedWork W2123659842 @default.
- W3099527124 hasRelatedWork W2149746113 @default.
- W3099527124 hasRelatedWork W2169846007 @default.
- W3099527124 hasRelatedWork W2353447341 @default.
- W3099527124 hasRelatedWork W2559328431 @default.
- W3099527124 hasRelatedWork W2731516015 @default.
- W3099527124 hasRelatedWork W2954251670 @default.
- W3099527124 hasRelatedWork W3048344987 @default.
- W3099527124 hasRelatedWork W3178472217 @default.
- W3099527124 hasVolume "9" @default.
- W3099527124 isParatext "false" @default.
- W3099527124 isRetracted "false" @default.
- W3099527124 magId "3099527124" @default.
- W3099527124 workType "article" @default.