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- W3099578512 abstract "Abstract Rheumatoid arthritis (RA) is known to be related to an elevated risk of infections because of its pathobiology and the use of immunosuppressive therapies. Reactivation of latent tuberculosis (TB) infection is a serious issue in patients with RA, especially after receiving anti‐TNFs therapy. TNF blocking reinforces the TB granuloma formation and maintenance and the growth of Mycobacterium tuberculosis (Mtb). After intercurrent of TB infection, the standard recommendation is that the treatment with TNF inhibitors to be withheld despite its impressive effect on suppression of inflammation until the infection has resolved. Knowing pathways and mechanisms that are common between two diseases might help to find the mechanistic basis of this comorbidity, as well as provide us a new approach to apply them as therapeutic targets or diagnostic biomarkers. Also, screening for latent TB before initiation of an anti‐TNF therapy can minimize complications. This review summarizes the shared gene signature between TB and RA and discusses the biomarkers for early detection of this infection, and screening procedures as well." @default.
- W3099578512 created "2020-11-23" @default.
- W3099578512 creator A5005668311 @default.
- W3099578512 creator A5012325640 @default.
- W3099578512 creator A5019467887 @default.
- W3099578512 creator A5036536670 @default.
- W3099578512 creator A5040176983 @default.
- W3099578512 creator A5071197619 @default.
- W3099578512 creator A5085329385 @default.
- W3099578512 date "2020-11-20" @default.
- W3099578512 modified "2023-10-18" @default.
- W3099578512 title "Tuberculosis comorbidity with rheumatoid arthritis: Gene signatures, associated biomarkers, and screening" @default.
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