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- W3099680081 abstract "Using NEDA, we compare patients with bicuspid aortic valve (BAV) stenosis to tricuspid aortic valve (TAV) stenosis, hypothesising that those with BAV would have a significantly different clinical phenotype. Adults with an AV mean gradient of >20mmHg (“moderate aortic stenosis”, AS), and in whom the AV morphology was specified, were selected from NEDA. Those with BAV or TAV were then compared using independent t-tests, Pearson Chi square test, and Mann Whitney-U test for non-normal distributions. Of 114,059 with echo-confirmed TAV, 4,938 (4.3%) had ≥moderate AS. Of the 3,454 patients with BAV, 1,177 (34.1%) had ≥moderate AS (p<0.001). BAV patients were substantially younger (58 years, 47-67 vs 80, 72-85, p<0.001). Where aortic dimensions were recorded (aortic root in 38%, ascending aorta in 44%), the diameters were significantly larger in BAV patients compared with TAV (3.6cm±0.58 vs 3.3cm±0.43, p<0.001; 3.7cm±0.83 vs 3.5cm±0.47, p<0.001 respectively). 5-year mortality was higher in TAV compared to BAV (42.4% vs 10.7%, p<0.001), however as BAV adults were younger at the time of AS diagnosis, the age at death was younger for BAV patients (76 years, 66–85 vs 85 years, 79-89, p<0.001). In this large community-based study, BAV patients are much more likely to develop AS, and those with moderate or greater AS are younger at the time of diagnosis, have larger ascending aortic dimensions and are almost a decade younger at the time of death, compared with TAV adults." @default.
- W3099680081 created "2020-11-23" @default.
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- W3099680081 date "2020-01-01" @default.
- W3099680081 modified "2023-10-18" @default.
- W3099680081 title "655 Different Clinical Features of Bicuspid Versus Tricuspid Aortic Stenosis; a Study From the National Echo Database of Australia (NEDA)" @default.
- W3099680081 doi "https://doi.org/10.1016/j.hlc.2020.09.662" @default.
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