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- W3099685873 abstract "Pathological studies on peripheral tissues have been conducted in patients with idiopathic rapid eye movement sleep behaviour disorder (iRBD) to investigate potential prodromal biomarkers before the development of overt synucleinopathies (online supplemental table 1). However, no studies have evaluated the in vivo tissues of the upper gastrointestinal (GI) tract in the iRBD population. Moreover, methodological heterogeneity makes it difficult to directly compare the results of each study on peripheral synucleinopathy. To address this problem, researchers who study tissues of the GI tract conducted an international collaborative study which showed that one immunohistochemistry (IHC) method showed 100% accuracy.1 This method is promising for unifying the method used in studies of the GI tract, but it has not yet been validated by other research groups.### Supplementary data[jnnp-2020-324743supp001.pdf]Therefore, the objectives of this study were (1) to evaluate the possibility of using upper GI specimens as a ‘prodromal’ pathological biomarker of synucleinopathy in patients with iRBD and (2) to validate the suggested staining method using full-depth surgical specimens.We evaluated upper and lower marginal blocks of the upper GI tract in the same way as in our previous study2 from eight patients with polysomnography-confirmed iRBD and matched controls selected by eligibility criteria (online supplemental table 2). After validation staining of the positive and negative control tissues using the suggested method 5 (hereafter called method 1),1 we decided to use both method 1 and the staining method in our previous GI study (hereafter called method 2; online supplemental table 3).2 Adjacent sections were stained using neurofilament IHC to confirm neural structures.2 Experienced raters (S-HP and CS) who were anonymised to the clinical information and staining methods evaluated the pathological findings. When two phosphorylated alpha-synuclein (pAS) staining methods showed discordant results, we further stained adjacent 5 µm sections of the GI …" @default.
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- W3099685873 date "2020-11-13" @default.
- W3099685873 modified "2023-10-10" @default.
- W3099685873 title "Gastric synucleinopathy as prodromal pathological biomarker in idiopathic REM sleep behaviour disorder" @default.
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- W3099685873 doi "https://doi.org/10.1136/jnnp-2020-324743" @default.
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