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• W3099698257 abstract "Purpose This work aimed to explore whether radiomic features on magnetic resonance diffusion weighted image (MR DWI) can be used to identify triple-negative breast cancer (TNBC) and other subtypes (non-TNBC). Materials and methods This retrospective study included 221 unilateral patients who underwent breast MR imaging prior to neoadjuvant chemotherapy. The subtypes of breast cancer include luminal A (n = 63), luminal B (n = 103), human epidermal growth factor receptor-2 (HER2) overexpressing (n = 30), and triple negative (n = 25). Radiomic features were extracted using Omini-Kinetic software on DWI. Student's t-test and Mann–Whitney U test were used to compare the features between TNBC and non-TNBC patients. Logistic regression analysis and receiver operating characteristic (ROC) curve were used to evaluate the diagnostic efficiency of radiomic features. The Fisher discriminant model was employed to distinguish TNBC and non-TNBC patients automatically. An additional validation dataset with 169 patients was utilized to validate the model. Results A total of 76 imaging features were extracted from each lesion on DWI images, and 12 radiomic features were statistically significant between TNBC and non-TNBC patients (P < 0.05). The area of receiver operating characteristic curve (AUC) was 0.817 to apply logistic regression analysis. The accuracy of Fisher discriminant model in distinguishing TNBC and non-TNBC patients was 95.4%, and leave-one-out cross validation was achieved with an accuracy of 83.7%. The same classification analysis of the validation dataset showed an accuracy of 83.4% and an AUC of 0.804. Conclusion Breast lesions exhibit differences in radiomic features from DWI, enabling good discrimination between TNBC and non-TNBC tumors." @default.
• W3099698257 created "2020-11-23" @default.
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• W3099698257 date "2021-04-01" @default.
• W3099698257 modified "2023-10-17" @default.
• W3099698257 title "Radiomic analysis on magnetic resonance diffusion weighted image in distinguishing triple-negative breast cancer from other subtypes: a feasibility study" @default.
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• W3099698257 doi "https://doi.org/10.1016/j.clinimag.2020.11.024" @default.
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