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- W3099859968 abstract "Cardiovascular disease (CVD) represents a major threat for human health. The available preventive and treatment interventions are insufficient to revert the underlying pathological processes, which underscores the urgency of alternative approaches. Mitochondria dysfunction plays a key role in the etiopathogenesis of CVD and is regarded as an intriguing target for the development of innovative therapies. Oxidative stress, mitochondrial permeability transition pore opening, and excessive fission are major noxious pathways amenable to drug therapy. Thanks to the advancements of nanotechnology research, several mitochondria-targeted drug delivery systems (DDS) have been optimized with improved pharmacokinetic and biocompatibility, and lower toxicity and antigenicity for application in the cardiovascular field. This review summarizes the recent progress and remaining obstacles in targeting mitochondria as a novel therapeutic option for CVD. The advantages of nanoparticle delivery over un-targeted strategies are also discussed." @default.
- W3099859968 created "2020-11-23" @default.
- W3099859968 creator A5020069774 @default.
- W3099859968 creator A5028459816 @default.
- W3099859968 creator A5045541726 @default.
- W3099859968 creator A5066707442 @default.
- W3099859968 date "2020-11-20" @default.
- W3099859968 modified "2023-09-23" @default.
- W3099859968 title "Mitochondria-Targeted Drug Delivery in Cardiovascular Disease: A Long Road to Nano-Cardio Medicine" @default.
- W3099859968 cites W1525029829 @default.
- W3099859968 cites W1555206873 @default.
- W3099859968 cites W1605189715 @default.
- W3099859968 cites W1605590279 @default.
- W3099859968 cites W1657534147 @default.
- W3099859968 cites W1699432502 @default.
- W3099859968 cites W1722845210 @default.
- W3099859968 cites W1767614014 @default.
- W3099859968 cites W1788023720 @default.
- W3099859968 cites W1843302206 @default.
- W3099859968 cites W1970140792 @default.
- W3099859968 cites W1971723295 @default.
- W3099859968 cites W1974839200 @default.
- W3099859968 cites W1983800701 @default.
- W3099859968 cites W1991774783 @default.
- W3099859968 cites W1994270731 @default.
- W3099859968 cites W1996739007 @default.
- W3099859968 cites W2003139013 @default.
- W3099859968 cites W2007509608 @default.
- W3099859968 cites W2017692041 @default.
- W3099859968 cites W2021294790 @default.
- W3099859968 cites W2022106942 @default.
- W3099859968 cites W2024784027 @default.
- W3099859968 cites W2030582660 @default.
- W3099859968 cites W2030938630 @default.
- W3099859968 cites W2032478715 @default.
- W3099859968 cites W2036114596 @default.
- W3099859968 cites W2036982001 @default.
- W3099859968 cites W2041326600 @default.
- W3099859968 cites W2046772778 @default.
- W3099859968 cites W2047577190 @default.
- W3099859968 cites W2056966258 @default.
- W3099859968 cites W2059009119 @default.
- W3099859968 cites W2060179384 @default.
- W3099859968 cites W2061490621 @default.
- W3099859968 cites W2071274761 @default.
- W3099859968 cites W2080891051 @default.
- W3099859968 cites W2082987920 @default.
- W3099859968 cites W2085367705 @default.
- W3099859968 cites W2087610485 @default.
- W3099859968 cites W2090913071 @default.
- W3099859968 cites W2091949587 @default.
- W3099859968 cites W2098408786 @default.
- W3099859968 cites W2103739341 @default.
- W3099859968 cites W2107426649 @default.
- W3099859968 cites W2114540161 @default.
- W3099859968 cites W2119301730 @default.
- W3099859968 cites W2123051296 @default.
- W3099859968 cites W2143049896 @default.
- W3099859968 cites W2143973329 @default.
- W3099859968 cites W2144600435 @default.
- W3099859968 cites W2146194815 @default.
- W3099859968 cites W2146540624 @default.
- W3099859968 cites W2148239267 @default.
- W3099859968 cites W2151202392 @default.
- W3099859968 cites W2153298328 @default.
- W3099859968 cites W2156654965 @default.
- W3099859968 cites W2159829960 @default.
- W3099859968 cites W2162583612 @default.
- W3099859968 cites W2163085099 @default.
- W3099859968 cites W2169364927 @default.
- W3099859968 cites W2176701303 @default.
- W3099859968 cites W2200357463 @default.
- W3099859968 cites W2251914552 @default.
- W3099859968 cites W2267116535 @default.
- W3099859968 cites W2297606889 @default.
- W3099859968 cites W2306834116 @default.
- W3099859968 cites W2331389349 @default.
- W3099859968 cites W2346053177 @default.
- W3099859968 cites W2467895334 @default.
- W3099859968 cites W2472826197 @default.
- W3099859968 cites W2478522641 @default.
- W3099859968 cites W2483878508 @default.
- W3099859968 cites W2488339703 @default.
- W3099859968 cites W2512747501 @default.
- W3099859968 cites W2515330695 @default.
- W3099859968 cites W2529689408 @default.
- W3099859968 cites W2560452919 @default.
- W3099859968 cites W2560757525 @default.
- W3099859968 cites W2562014731 @default.
- W3099859968 cites W2588299905 @default.
- W3099859968 cites W2590373381 @default.
- W3099859968 cites W2728985030 @default.
- W3099859968 cites W2756660214 @default.
- W3099859968 cites W2759187688 @default.
- W3099859968 cites W2763000909 @default.
- W3099859968 cites W2769410191 @default.
- W3099859968 cites W2770621003 @default.
- W3099859968 cites W2773343324 @default.