Matches in SemOpenAlex for { <https://semopenalex.org/work/W3099886290> ?p ?o ?g. }
- W3099886290 endingPage "475" @default.
- W3099886290 startingPage "475" @default.
- W3099886290 abstract "An informative probe of myosin cross-bridge behaviour in active muscle is a mechanical transient experiment where, for example, a fully active muscle initially held at constant length is suddenly shortened to a new fixed length, providing a force transient, or has its load suddenly reduced, providing a length transient. We describe the simplest cross-bridge mechanical cycle we could find to model these transients. We show using the statistical mechanics of 50,000 cross-bridges that a simple cycle with two actin-attached cross-bridge states, one producing no force and the other producing force, will explain much of what has been observed experimentally, and we discuss the implications of this modelling for our understanding of how muscle works. We show that this same simple model will explain, reasonably well, the isotonic mechanical and X-ray transients under different loads observed by Reconditi et al. (2004, Nature 428, 578) and that there is no need to invoke different cross-bridge step sizes under these different conditions; a step size of 100 Å works well for all loads. We do not claim that this model provides a total mechanical explanation of how muscle works. However, we do suggest that only if there are other observations that cannot be explained by this simple model should something more complicated be considered." @default.
- W3099886290 created "2020-11-23" @default.
- W3099886290 creator A5019751830 @default.
- W3099886290 creator A5077556024 @default.
- W3099886290 date "2020-12-16" @default.
- W3099886290 modified "2023-10-18" @default.
- W3099886290 title "The Transient Mechanics of Muscle Require Only a Single Force-Producing Cross-Bridge State and a 100 Å Working Stroke" @default.
- W3099886290 cites W1511298847 @default.
- W3099886290 cites W1532818164 @default.
- W3099886290 cites W1543092426 @default.
- W3099886290 cites W1598494409 @default.
- W3099886290 cites W1810428052 @default.
- W3099886290 cites W1912801954 @default.
- W3099886290 cites W1973038113 @default.
- W3099886290 cites W1976053070 @default.
- W3099886290 cites W1977862168 @default.
- W3099886290 cites W1980685237 @default.
- W3099886290 cites W1988012100 @default.
- W3099886290 cites W2001170107 @default.
- W3099886290 cites W2003300699 @default.
- W3099886290 cites W2007456935 @default.
- W3099886290 cites W2008568258 @default.
- W3099886290 cites W2025627402 @default.
- W3099886290 cites W2026145805 @default.
- W3099886290 cites W2030175846 @default.
- W3099886290 cites W2032127615 @default.
- W3099886290 cites W2032811423 @default.
- W3099886290 cites W2033867498 @default.
- W3099886290 cites W2046003039 @default.
- W3099886290 cites W2049607475 @default.
- W3099886290 cites W2050701613 @default.
- W3099886290 cites W2058963992 @default.
- W3099886290 cites W2060959865 @default.
- W3099886290 cites W2062891165 @default.
- W3099886290 cites W2062977071 @default.
- W3099886290 cites W2065409477 @default.
- W3099886290 cites W2069953906 @default.
- W3099886290 cites W2070037836 @default.
- W3099886290 cites W2071457729 @default.
- W3099886290 cites W2079137640 @default.
- W3099886290 cites W2079787801 @default.
- W3099886290 cites W2083417939 @default.
- W3099886290 cites W2105714029 @default.
- W3099886290 cites W2113092027 @default.
- W3099886290 cites W2124256968 @default.
- W3099886290 cites W2126468848 @default.
- W3099886290 cites W2127917887 @default.
- W3099886290 cites W2138198227 @default.
- W3099886290 cites W2142289629 @default.
- W3099886290 cites W2145364923 @default.
- W3099886290 cites W2154663686 @default.
- W3099886290 cites W2169949242 @default.
- W3099886290 cites W2334869316 @default.
- W3099886290 cites W2528303727 @default.
- W3099886290 cites W2545809989 @default.
- W3099886290 cites W2547372136 @default.
- W3099886290 cites W2556378489 @default.
- W3099886290 cites W2920918327 @default.
- W3099886290 cites W2988948413 @default.
- W3099886290 cites W4246118847 @default.
- W3099886290 cites W789458867 @default.
- W3099886290 doi "https://doi.org/10.3390/biology9120475" @default.
- W3099886290 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7765809" @default.
- W3099886290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33339405" @default.
- W3099886290 hasPublicationYear "2020" @default.
- W3099886290 type Work @default.
- W3099886290 sameAs 3099886290 @default.
- W3099886290 citedByCount "1" @default.
- W3099886290 countsByYear W30998862902022 @default.
- W3099886290 crossrefType "journal-article" @default.
- W3099886290 hasAuthorship W3099886290A5019751830 @default.
- W3099886290 hasAuthorship W3099886290A5077556024 @default.
- W3099886290 hasBestOaLocation W30998862901 @default.
- W3099886290 hasConcept C100776233 @default.
- W3099886290 hasConcept C105702510 @default.
- W3099886290 hasConcept C111472728 @default.
- W3099886290 hasConcept C111919701 @default.
- W3099886290 hasConcept C121332964 @default.
- W3099886290 hasConcept C12554922 @default.
- W3099886290 hasConcept C126322002 @default.
- W3099886290 hasConcept C138885662 @default.
- W3099886290 hasConcept C2780586882 @default.
- W3099886290 hasConcept C2780799671 @default.
- W3099886290 hasConcept C41008148 @default.
- W3099886290 hasConcept C57879066 @default.
- W3099886290 hasConcept C6997183 @default.
- W3099886290 hasConcept C71924100 @default.
- W3099886290 hasConcept C74650414 @default.
- W3099886290 hasConcept C77056095 @default.
- W3099886290 hasConcept C86803240 @default.
- W3099886290 hasConceptScore W3099886290C100776233 @default.
- W3099886290 hasConceptScore W3099886290C105702510 @default.
- W3099886290 hasConceptScore W3099886290C111472728 @default.
- W3099886290 hasConceptScore W3099886290C111919701 @default.
- W3099886290 hasConceptScore W3099886290C121332964 @default.
- W3099886290 hasConceptScore W3099886290C12554922 @default.
- W3099886290 hasConceptScore W3099886290C126322002 @default.
- W3099886290 hasConceptScore W3099886290C138885662 @default.