Matches in SemOpenAlex for { <https://semopenalex.org/work/W3099899798> ?p ?o ?g. }
- W3099899798 abstract "Abstract The health impact of prolonged space flight on the human body is not well understood. Liquid biopsies based on cell-free DNA (cfDNA) or exosome analysis provide a noninvasive approach to monitor the dynamics of genomic, epigenomic and proteomic biomarkers, and the occurrence of DNA damage, physiological stress, and immune responses. To study the molecular consequences of spaceflight we profiled cfDNA isolated from plasma of an astronaut (TW) during a year-long mission on the International Space Station (ISS), sampling before, during, and after spaceflight, and compared the results to cfDNA profiling of the subject’s identical twin (HR) who remained on Earth, as well as healthy donors. We characterized cfDNA concentration and fragment size, and the positioning of nucleosomes on cfDNA, observing a significant increase in the proportion of cell-free mitochondrial DNA inflight, suggesting that cf-mtDNA is a potential biomarker for space flight-associated stress, and that this result was robust to ambient transit from the International Space Station (ISS). Analysis of exosomes isolated from post-flight plasma revealed a 30-fold increase in circulating exosomes and distinct exosomal protein cargo, including brain-derived peptides, in TW compared to HR and all known controls. This study provides the first longitudinal analysis of astronaut cfDNA during spaceflight, as well as the first exosome profiles, and highlights cf-mtDNA levels as a potential biomarker for physiological stress or immune system responses related to microgravity, radiation exposure, and other unique environmental conditions on the ISS." @default.
- W3099899798 created "2020-11-23" @default.
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- W3099899798 date "2020-11-08" @default.
- W3099899798 modified "2023-09-30" @default.
- W3099899798 title "Cell-free DNA (cfDNA) and exosome profiling from a year-long human spaceflight reveals circulating biomarkers" @default.
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- W3099899798 doi "https://doi.org/10.1101/2020.11.08.373530" @default.
- W3099899798 hasPublicationYear "2020" @default.