Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100012142> ?p ?o ?g. }
- W3100012142 startingPage "039859" @default.
- W3100012142 abstract "The contribution of pre-existing and de novo genetic variation towards clonal adaptation is poorly understood, but essential to design successful antibiotic or cancer therapies. To address this, we evolved genetically diverse populations of budding yeast, S. cerevisiae, consisting of ∼107 diploid cells with unique haplotype combinations. We studied the asexual evolution of these populations under selective inhibition of DNA replication and cell metabolism by time-resolved whole-genome sequencing and phenotyping. All populations underwent clonal expansions driven by de novo mutations, but remained genetically and phenotypically diverse. Despite the genetic diversity of the founder cells, we observed recurrent adaptive mutations. However, the founding fitness variance limited the scope for adaptive mutations to expand. The clones exhibited continued evolution by widespread genome instability, rendering recessive de novo mutations homozygous and refining pre-existing variation. Our results show that three intertwined processes dominate the adaptive response: exploiting genetic backgrounds, de novo mutations and genome instability." @default.
- W3100012142 created "2020-11-23" @default.
- W3100012142 creator A5012677271 @default.
- W3100012142 creator A5029927126 @default.
- W3100012142 creator A5045241718 @default.
- W3100012142 creator A5046081802 @default.
- W3100012142 creator A5050753246 @default.
- W3100012142 creator A5061483267 @default.
- W3100012142 creator A5062269665 @default.
- W3100012142 creator A5063706428 @default.
- W3100012142 creator A5068241183 @default.
- W3100012142 creator A5082147440 @default.
- W3100012142 creator A5084279149 @default.
- W3100012142 date "2016-07-27" @default.
- W3100012142 modified "2023-09-25" @default.
- W3100012142 title "Background-dependent effects of selection on subclonal heterogeneity" @default.
- W3100012142 cites W1915104237 @default.
- W3100012142 cites W1951724000 @default.
- W3100012142 cites W1973175445 @default.
- W3100012142 cites W1981457167 @default.
- W3100012142 cites W1985561503 @default.
- W3100012142 cites W1991691392 @default.
- W3100012142 cites W1995606284 @default.
- W3100012142 cites W1997478924 @default.
- W3100012142 cites W1999718739 @default.
- W3100012142 cites W2007346133 @default.
- W3100012142 cites W2012977051 @default.
- W3100012142 cites W2013314158 @default.
- W3100012142 cites W2018085822 @default.
- W3100012142 cites W2018288777 @default.
- W3100012142 cites W2024342745 @default.
- W3100012142 cites W2026412193 @default.
- W3100012142 cites W2039279598 @default.
- W3100012142 cites W2052975116 @default.
- W3100012142 cites W2060965924 @default.
- W3100012142 cites W2067829962 @default.
- W3100012142 cites W2086969670 @default.
- W3100012142 cites W2088580309 @default.
- W3100012142 cites W2103441770 @default.
- W3100012142 cites W2108543631 @default.
- W3100012142 cites W2109948920 @default.
- W3100012142 cites W2110451776 @default.
- W3100012142 cites W2110876945 @default.
- W3100012142 cites W2111187843 @default.
- W3100012142 cites W2117737648 @default.
- W3100012142 cites W2122881747 @default.
- W3100012142 cites W2128099419 @default.
- W3100012142 cites W2128726449 @default.
- W3100012142 cites W2133212095 @default.
- W3100012142 cites W2139316770 @default.
- W3100012142 cites W2148323109 @default.
- W3100012142 cites W2150131459 @default.
- W3100012142 cites W2150575159 @default.
- W3100012142 cites W2164696589 @default.
- W3100012142 cites W2165017975 @default.
- W3100012142 cites W2168133698 @default.
- W3100012142 cites W2170343590 @default.
- W3100012142 cites W2170392103 @default.
- W3100012142 cites W2171197491 @default.
- W3100012142 cites W2171679524 @default.
- W3100012142 cites W2268038961 @default.
- W3100012142 cites W2342557520 @default.
- W3100012142 cites W2417483443 @default.
- W3100012142 cites W2949073718 @default.
- W3100012142 cites W2952887669 @default.
- W3100012142 hasPublicationYear "2016" @default.
- W3100012142 type Work @default.
- W3100012142 sameAs 3100012142 @default.
- W3100012142 citedByCount "0" @default.
- W3100012142 crossrefType "posted-content" @default.
- W3100012142 hasAuthorship W3100012142A5012677271 @default.
- W3100012142 hasAuthorship W3100012142A5029927126 @default.
- W3100012142 hasAuthorship W3100012142A5045241718 @default.
- W3100012142 hasAuthorship W3100012142A5046081802 @default.
- W3100012142 hasAuthorship W3100012142A5050753246 @default.
- W3100012142 hasAuthorship W3100012142A5061483267 @default.
- W3100012142 hasAuthorship W3100012142A5062269665 @default.
- W3100012142 hasAuthorship W3100012142A5063706428 @default.
- W3100012142 hasAuthorship W3100012142A5068241183 @default.
- W3100012142 hasAuthorship W3100012142A5082147440 @default.
- W3100012142 hasAuthorship W3100012142A5084279149 @default.
- W3100012142 hasBestOaLocation W31000121421 @default.
- W3100012142 hasConcept C104317684 @default.
- W3100012142 hasConcept C113968399 @default.
- W3100012142 hasConcept C127716648 @default.
- W3100012142 hasConcept C139807058 @default.
- W3100012142 hasConcept C141231307 @default.
- W3100012142 hasConcept C143425029 @default.
- W3100012142 hasConcept C169760540 @default.
- W3100012142 hasConcept C178169997 @default.
- W3100012142 hasConcept C2910240311 @default.
- W3100012142 hasConcept C54355233 @default.
- W3100012142 hasConcept C552990157 @default.
- W3100012142 hasConcept C68873052 @default.
- W3100012142 hasConcept C78458016 @default.
- W3100012142 hasConcept C86803240 @default.
- W3100012142 hasConceptScore W3100012142C104317684 @default.
- W3100012142 hasConceptScore W3100012142C113968399 @default.
- W3100012142 hasConceptScore W3100012142C127716648 @default.