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- W3100014595 endingPage "1166" @default.
- W3100014595 startingPage "1138" @default.
- W3100014595 abstract "Vitiligo is an autoimmune depigment disease results from extensive melanocytes destruction. The destruction of melanocyte is thought to be of multifactorial causation. Genome-wide associated studies have identified single-nucleotide polymorphisms in a panel of susceptible loci as risk factors in melanocyte death. But vitiligo onset can't be solely attributed to a susceptive genetic background. Oxidative stress triggered by elevated levels of reactive oxygen species accounts for melanocytic molecular and organelle dysfunction, a minority of melanocyte demise, and melanocyte-specific antigens exposure. Of note, the self-responsive immune function directly contributes to the bulk of melanocyte deaths in vitiligo. The aberrantly heightened innate immunity, type-1-skewed T helper, and incompetent regulatory T cells tip the balance toward autoreaction and CD8+ cytotoxic T lymphocytes finally execute the killing of melanocytes, possibly alarmed by resident memory T cells. In addition to the well-established apoptosis and necrosis, we discuss several death modalities like oxeiptosis, ferroptosis, and necroptosis that are probably employed in melanocyte destruction. This review focuses on the various mechanisms of melanocytic death in vitiligo pathogenesis to demonstrate a panorama of that. We hope to provide new insights into vitiligo pathogenesis and treatment strategies by the review." @default.
- W3100014595 created "2020-11-23" @default.
- W3100014595 creator A5000924621 @default.
- W3100014595 creator A5023006263 @default.
- W3100014595 creator A5040238984 @default.
- W3100014595 date "2020-11-17" @default.
- W3100014595 modified "2023-10-14" @default.
- W3100014595 title "Mechanisms of melanocyte death in vitiligo" @default.
- W3100014595 cites W1502306453 @default.
- W3100014595 cites W1523845694 @default.
- W3100014595 cites W1557089723 @default.
- W3100014595 cites W1589731655 @default.
- W3100014595 cites W1596403261 @default.
- W3100014595 cites W1602488051 @default.
- W3100014595 cites W1608140060 @default.
- W3100014595 cites W1646626736 @default.
- W3100014595 cites W1912778406 @default.
- W3100014595 cites W1918582962 @default.
- W3100014595 cites W1952523607 @default.
- W3100014595 cites W1958767730 @default.
- W3100014595 cites W1963500531 @default.
- W3100014595 cites W1963502913 @default.
- W3100014595 cites W1964674650 @default.
- W3100014595 cites W1965968836 @default.
- W3100014595 cites W1970450187 @default.
- W3100014595 cites W1971069223 @default.
- W3100014595 cites W1971079822 @default.
- W3100014595 cites W1982092001 @default.
- W3100014595 cites W1982984141 @default.
- W3100014595 cites W1983805005 @default.
- W3100014595 cites W1984365989 @default.
- W3100014595 cites W1995134644 @default.
- W3100014595 cites W1996908598 @default.
- W3100014595 cites W1997183854 @default.
- W3100014595 cites W1998051584 @default.
- W3100014595 cites W1999832688 @default.
- W3100014595 cites W2001399725 @default.
- W3100014595 cites W2001675597 @default.
- W3100014595 cites W2005578201 @default.
- W3100014595 cites W2006428939 @default.
- W3100014595 cites W2009644403 @default.
- W3100014595 cites W2009662125 @default.
- W3100014595 cites W2009865483 @default.
- W3100014595 cites W2015562865 @default.
- W3100014595 cites W2015784918 @default.
- W3100014595 cites W2016026564 @default.
- W3100014595 cites W2022019032 @default.
- W3100014595 cites W2022373534 @default.
- W3100014595 cites W2022978891 @default.
- W3100014595 cites W2024100879 @default.
- W3100014595 cites W2024594386 @default.
- W3100014595 cites W2029116768 @default.
- W3100014595 cites W2029781663 @default.
- W3100014595 cites W2030799356 @default.
- W3100014595 cites W2032052390 @default.
- W3100014595 cites W2033004300 @default.
- W3100014595 cites W2033347574 @default.
- W3100014595 cites W2041248739 @default.
- W3100014595 cites W2042140414 @default.
- W3100014595 cites W2042194530 @default.
- W3100014595 cites W2050703639 @default.
- W3100014595 cites W2052234755 @default.
- W3100014595 cites W2052275203 @default.
- W3100014595 cites W2053950470 @default.
- W3100014595 cites W2056144049 @default.
- W3100014595 cites W2060069128 @default.
- W3100014595 cites W2062047582 @default.
- W3100014595 cites W2064021186 @default.
- W3100014595 cites W2064155071 @default.
- W3100014595 cites W2065684908 @default.
- W3100014595 cites W2067107606 @default.
- W3100014595 cites W2069384112 @default.
- W3100014595 cites W2072166430 @default.
- W3100014595 cites W2073062251 @default.
- W3100014595 cites W2076999313 @default.
- W3100014595 cites W2078780781 @default.
- W3100014595 cites W2079141430 @default.
- W3100014595 cites W2085006338 @default.
- W3100014595 cites W2085106134 @default.
- W3100014595 cites W2087440959 @default.
- W3100014595 cites W2089097264 @default.
- W3100014595 cites W2089954661 @default.
- W3100014595 cites W2092818422 @default.
- W3100014595 cites W2094128254 @default.
- W3100014595 cites W2094573831 @default.
- W3100014595 cites W2097803930 @default.
- W3100014595 cites W2098787118 @default.
- W3100014595 cites W2099876644 @default.
- W3100014595 cites W2102373578 @default.
- W3100014595 cites W2103667120 @default.
- W3100014595 cites W2104363212 @default.
- W3100014595 cites W2106107076 @default.
- W3100014595 cites W2106668806 @default.
- W3100014595 cites W2106913788 @default.
- W3100014595 cites W2112032088 @default.
- W3100014595 cites W2113628320 @default.
- W3100014595 cites W2113765099 @default.
- W3100014595 cites W2119472020 @default.