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- W3100014904 abstract "ABSTRACT Morphogenesis involves the dynamic interplay of biochemical, mechanical and electrical processes. Here we ask: to what extent can the course of morphogenesis be modulated and controlled by an external electric field? We show that above a critical amplitude, an external electric field can halt morphogenesis in Hydra regeneration. Moreover, above this critical amplitude, the electric field can even lead to reversal dynamics: a fully developed Hydra folds back into its incipient spheroid morphology. The potential to renew morphogenesis is re-exposed when the field is reduced back to amplitudes below criticality. These dynamics are accompanied by modulations of the Wnt3 activity, a central component of the head organizer in Hydra . Reversal of morphogenesis is shown to be triggered by enhanced epithelial electrical excitations, accompanied by intensified calcium activity, indicating that electrical processes play an instructive role to a level that can direct developmental trajectories. Reversal of morphogenesis by external fields, calls for extending its framework beyond programmatic, forward-driven, hierarchical processes." @default.
- W3100014904 created "2020-11-23" @default.
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- W3100014904 date "2019-04-05" @default.
- W3100014904 modified "2023-10-18" @default.
- W3100014904 title "Electric-induced reversal of morphogenesis inHydra" @default.
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- W3100014904 doi "https://doi.org/10.1101/600395" @default.
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